(23 nodes) Positive regulation of activated T cell proliferation network (Ictidomys tridecemlineatus)

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Predicted Interactions

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Your Input:
	PYCARD	PYD and CARD domain containing. (194 aa)
	LOC101968601	Uncharacterized protein. (80 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (827 aa)
	IGF1	Insulin like growth factor 1. (166 aa)
	ENSSTOP00000025794	Uncharacterized protein. (78 aa)
	AGER	Advanced glycosylation end-product specific receptor. (450 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	Rps3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (244 aa)
	IL2RA	Interleukin 2 receptor subunit alpha. (251 aa)
	IGF2	Insulin like growth factor 2. (180 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	IL23A	Interleukin 23 subunit alpha. (185 aa)
	Cd86	Ig-like domain-containing protein. (289 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
	STAT5B	Signal transducer and activator of transcription. (765 aa)
	STAT5A	Signal transducer and activator of transcription. (773 aa)
	SLAMF1	Signaling lymphocytic activation molecule family member 1. (335 aa)
	JAK3	Tyrosine-protein kinase. (1042 aa)
	IL27RA	Interleukin 27 receptor subunit alpha. (569 aa)
	IGFBP2	Insulin like growth factor binding protein 2. (308 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (511 aa)
	EPO	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	JAK3	ENSSTOP00000025224	ENSSTOP00000006957	Advanced glycosylation end-product specific receptor.	Tyrosine-protein kinase.	0.801
Cd86	IL18	ENSSTOP00000002363	ENSSTOP00000015111	Ig-like domain-containing protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.460
Cd86	IL2	ENSSTOP00000002363	ENSSTOP00000014415	Ig-like domain-containing protein.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.565
EPO	IL12B	ENSSTOP00000012243	ENSSTOP00000004480	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.839
EPO	IL2	ENSSTOP00000012243	ENSSTOP00000014415	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.863
EPO	IL23A	ENSSTOP00000012243	ENSSTOP00000014301	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Interleukin 23 subunit alpha.	0.837
EPO	IL2RA	ENSSTOP00000012243	ENSSTOP00000020804	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Interleukin 2 receptor subunit alpha.	0.845
EPO	JAK3	ENSSTOP00000012243	ENSSTOP00000006957	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.881
GPAM	IL2	ENSSTOP00000031912	ENSSTOP00000014415	Glycerol-3-phosphate acyltransferase 1, mitochondrial.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.606
IGF1	IGF2	ENSSTOP00000029785	ENSSTOP00000018700	Insulin like growth factor 1.	Insulin like growth factor 2.	0.934
IGF1	IGFBP2	ENSSTOP00000029785	ENSSTOP00000010058	Insulin like growth factor 1.	Insulin like growth factor binding protein 2.	0.967
IGF1	JAK3	ENSSTOP00000029785	ENSSTOP00000006957	Insulin like growth factor 1.	Tyrosine-protein kinase.	0.482
IGF2	IGF1	ENSSTOP00000018700	ENSSTOP00000029785	Insulin like growth factor 2.	Insulin like growth factor 1.	0.934
IGF2	IGFBP2	ENSSTOP00000018700	ENSSTOP00000010058	Insulin like growth factor 2.	Insulin like growth factor binding protein 2.	0.914
IGFBP2	IGF1	ENSSTOP00000010058	ENSSTOP00000029785	Insulin like growth factor binding protein 2.	Insulin like growth factor 1.	0.967
IGFBP2	IGF2	ENSSTOP00000010058	ENSSTOP00000018700	Insulin like growth factor binding protein 2.	Insulin like growth factor 2.	0.914
IL12B	EPO	ENSSTOP00000004480	ENSSTOP00000012243	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.839
IL12B	IL18	ENSSTOP00000004480	ENSSTOP00000015111	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.489
IL12B	IL2	ENSSTOP00000004480	ENSSTOP00000014415	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.889
IL12B	IL23A	ENSSTOP00000004480	ENSSTOP00000014301	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin 23 subunit alpha.	0.997