(82 nodes) Regulation of protein import into nucleus network (Ictidomys tridecemlineatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101975245	HATPase_c domain-containing protein. (733 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
	Brca1	Uncharacterized protein. (353 aa)
	ZIC1	Zic family member 1. (447 aa)
	PTPN5	Protein tyrosine phosphatase non-receptor type 5. (538 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	Pik3r2	Uncharacterized protein. (724 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (703 aa)
	ZPR1	ZPR1 zinc finger. (459 aa)
	I3M249_ICTTR	Uncharacterized protein. (683 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (843 aa)
	EI24	EI24 autophagy associated transmembrane protein. (326 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	I3M4W8_ICTTR	Uncharacterized protein. (207 aa)
	FLNA	Filamin A. (2647 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2782 aa)
	DMAP1	DNA methyltransferase 1 associated protein 1. (468 aa)
	LOC101973389	Uncharacterized protein. (182 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (230 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	ANGPT1	Angiopoietin 1. (497 aa)
	Tardbp	Uncharacterized protein. (414 aa)
	NUP54	Nucleoporin 54. (509 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (733 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (478 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (437 aa)
	PKIA	cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
	RAB23	RAB23, member RAS oncogene family. (237 aa)
	IPO5	Importin 5. (1078 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	AGTR2	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	TPR	Translocated promoter region, nuclear basket protein. (2435 aa)
	CHP1	Calcineurin like EF-hand protein 1. (195 aa)
	MDFIC	MyoD family inhibitor domain containing. (246 aa)
	MAVS	Mitochondrial antiviral signaling protein. (509 aa)
	PKIG	cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
	FERMT1	Fermitin family member 1. (596 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	SHH	Sonic hedgehog signaling molecule. (370 aa)
	NUP62	Nucleoporin 62. (520 aa)
	I3MVL6_ICTTR	Uncharacterized protein. (192 aa)
	AKAP1	A-kinase anchoring protein 1. (770 aa)
	Ect2	Uncharacterized protein. (188 aa)
	Rbm22	RRM domain-containing protein. (362 aa)
	RAN	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (210 aa)
	TRIM28	Tripartite motif containing 28. (835 aa)
	I3N090_ICTTR	Uncharacterized protein. (207 aa)
	BAG3	BCL2 associated athanogene 3. (581 aa)
	LOC101960206	Uncharacterized protein. (207 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	Cabp1	Uncharacterized protein. (241 aa)
	LOC101959054	Uncharacterized protein. (395 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (599 aa)
	APOD	Apolipoprotein D. (193 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (724 aa)
	CHP2	Calcineurin like EF-hand protein 2. (195 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	GLI3	GLI family zinc finger 3. (1582 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	Sumo1	Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa)
	UFM1	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. (85 aa)
	ENSSTOP00000031005	Uncharacterized protein. (410 aa)
	EFCAB7	EF-hand calcium binding domain 7. (627 aa)
	TEK	TEK receptor tyrosine kinase. (1124 aa)
	ENSSTOP00000029812	Small ubiquitin-related modifier. (112 aa)
	JUP	Junction plakoglobin. (780 aa)
	ENSSTOP00000028463	Uncharacterized protein. (159 aa)
	LOC101971510	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (161 aa)
	ENSSTOP00000027930	Uncharacterized protein. (173 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	HYAL2	Hyaluronidase. (472 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	NF1	Neurofibromin 1. (2473 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (473 aa)
	SIRT6	Sirtuin 6. (351 aa)
	ENSSTOP00000025436	Uncharacterized protein. (68 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	NUP58	Nucleoporin 58. (599 aa)
	UACA	Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1413 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT1	Pik3r2	ENSSTOP00000007177	ENSSTOP00000001718	Angiopoietin 1.	Uncharacterized protein.	0.553
ANGPT1	TEK	ENSSTOP00000007177	ENSSTOP00000030617	Angiopoietin 1.	TEK receptor tyrosine kinase.	0.995
BAG3	HSP90AA1	ENSSTOP00000018038	ENSSTOP00000008658	BCL2 associated athanogene 3.	Heat shock protein 90 alpha family class A member 1.	0.466
BAG3	HSP90AB1	ENSSTOP00000018038	ENSSTOP00000022132	BCL2 associated athanogene 3.	Heat shock protein 90 alpha family class B member 1.	0.644
BAG3	I3M249_ICTTR	ENSSTOP00000018038	ENSSTOP00000003001	BCL2 associated athanogene 3.	Uncharacterized protein.	0.466
BAG3	JAK2	ENSSTOP00000018038	ENSSTOP00000005984	BCL2 associated athanogene 3.	Tyrosine-protein kinase.	0.504
BAG3	LOC101975245	ENSSTOP00000018038	ENSSTOP00000023173	BCL2 associated athanogene 3.	HATPase_c domain-containing protein.	0.466
BAG3	PIK3R1	ENSSTOP00000018038	ENSSTOP00000026032	BCL2 associated athanogene 3.	Phosphoinositide-3-kinase regulatory subunit 1.	0.502
BAG3	Pik3r2	ENSSTOP00000018038	ENSSTOP00000001718	BCL2 associated athanogene 3.	Uncharacterized protein.	0.502
BAG3	TNFRSF1A	ENSSTOP00000018038	ENSSTOP00000009024	BCL2 associated athanogene 3.	TNF receptor superfamily member 1A.	0.716
BMP4	SHH	ENSSTOP00000001023	ENSSTOP00000015201	Bone morphogenetic protein 4.	Sonic hedgehog signaling molecule.	0.691
BMP4	SMO	ENSSTOP00000001023	ENSSTOP00000010265	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.408
Brca1	CDK1	ENSSTOP00000000449	ENSSTOP00000027835	Uncharacterized protein.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.732
Brca1	ENSSTOP00000027930	ENSSTOP00000000449	ENSSTOP00000027930	Uncharacterized protein.	Uncharacterized protein.	0.899
Brca1	ENSSTOP00000029812	ENSSTOP00000000449	ENSSTOP00000029812	Uncharacterized protein.	Small ubiquitin-related modifier.	0.582
Brca1	FLNA	ENSSTOP00000000449	ENSSTOP00000004582	Uncharacterized protein.	Filamin A.	0.504
Brca1	NF1	ENSSTOP00000000449	ENSSTOP00000027148	Uncharacterized protein.	Neurofibromin 1.	0.525
Brca1	Sumo1	ENSSTOP00000000449	ENSSTOP00000031441	Uncharacterized protein.	Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...]	0.582
CDH1	HCLS1	ENSSTOP00000032600	ENSSTOP00000008987	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	Hematopoietic cell-specific Lyn substrate 1.	0.455
CDH1	HNF4A	ENSSTOP00000032600	ENSSTOP00000027193	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	Hepatocyte nuclear factor 4 alpha.	0.431