STRINGSTRING
SRRD SRRD PPARG PPARG MAPK8 MAPK8 RORA RORA CRY2 CRY2 RBM4B RBM4B PPARA PPARA PRKAA2 PRKAA2 PRKDC PRKDC PPP1CC PPP1CC NPAS2 NPAS2 MTNR1B MTNR1B Fbxl17 Fbxl17 ADCY1 ADCY1 PER2 PER2 Tardbp Tardbp MTA1 MTA1 DDB1 DDB1 FBXW9 FBXW9 HCRTR2 HCRTR2 NR1D1 NR1D1 NMU NMU UBE3A UBE3A USP2 USP2 PER1 PER1 LOC101967743 LOC101967743 FBXL12 FBXL12 SPSB4 SPSB4 TOP2A TOP2A I3M4W8_ICTTR I3M4W8_ICTTR MAGED1 MAGED1 Sik1 Sik1 DRD2 DRD2 KDM2A KDM2A OPN4 OPN4 Nr1d2 Nr1d2 MAPK10 MAPK10 CSNK1D CSNK1D ARNTL2 ARNTL2 USP9X USP9X BHLHE40 BHLHE40 THRAP3 THRAP3 ROCK2 ROCK2 MTOR MTOR Fbxl21p Fbxl21p FBXL3 FBXL3 USP7 USP7 MAPK9 MAPK9 ENSSTOP00000030497 ENSSTOP00000030497 PSPC1 PSPC1 EZH2 EZH2 ENSSTOP00000029050 ENSSTOP00000029050 KAT5 KAT5 SUV39H2 SUV39H2 ENSSTOP00000028212 ENSSTOP00000028212 CRTC1 CRTC1 NLGN1 NLGN1 CDK1 CDK1 CHRNB2 CHRNB2 PROX1 PROX1 HNF4A HNF4A SIAH2 SIAH2 RORB RORB CCAR2 CCAR2 OPN5 OPN5 PPARGC1A PPARGC1A PPP1CA PPP1CA ATG7 ATG7 CRY1 CRY1 SIRT6 SIRT6 PRKCG PRKCG NPS NPS PTGER3 PTGER3 PRKAA1 PRKAA1 PDE6B PDE6B CIPC CIPC GHRL GHRL GSK3B GSK3B ZFHX3 ZFHX3 FBXW11 FBXW11 LOC101972479 LOC101972479 KCNA2 KCNA2 ID2 ID2 LOC101959054 LOC101959054 BTRC BTRC RBM4 RBM4 MAGEL2 MAGEL2 FBXL6 FBXL6 LEPR LEPR TP53 TP53 LOC101972772 LOC101972772 RORC RORC PTGER4 PTGER4 ATOH7 ATOH7 LOC101960206 LOC101960206 ADRB1 ADRB1 PHLPP1 PHLPP1 I3N090_ICTTR I3N090_ICTTR PPP1CB PPP1CB DRD4 DRD4 FBXW7 FBXW7 DRD3 DRD3 ARNTL ARNTL I3MVL6_ICTTR I3MVL6_ICTTR KLF10 KLF10 DRD1 DRD1 SIN3A SIN3A Fbxl8 Fbxl8 PIWIL2 PIWIL2 CREB1 CREB1 HDAC3 HDAC3 CLOCK CLOCK Fbxl22 Fbxl22 NONO NONO PMCH PMCH GHRHR GHRHR SUV39H1 SUV39H1 NOCT NOCT TIMELESS TIMELESS PER3 PER3 Sfpq Sfpq HNRNPD HNRNPD PML PML
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRRDSRR1 domain containing. (301 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RORARAR related orphan receptor A. (521 aa)
CRY2Cryptochrome circadian regulator 2. (593 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
NPAS2Neuronal PAS domain protein 2. (814 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (364 aa)
Fbxl17Uncharacterized protein. (220 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
PER2Period circadian regulator 2. (1297 aa)
TardbpUncharacterized protein. (414 aa)
MTA1Metastasis associated 1. (689 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
FBXW9F-box and WD repeat domain containing 9. (462 aa)
HCRTR2Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (461 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (611 aa)
NMUNeuromedin U. (170 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (874 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (612 aa)
PER1Period circadian regulator 1. (1294 aa)
LOC101967743Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
FBXL12F-box and leucine rich repeat protein 12. (326 aa)
SPSB4SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1534 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
MAGED1MAGE family member D1. (783 aa)
Sik1Uncharacterized protein. (776 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
KDM2ALysine demethylase 2A. (1162 aa)
OPN4Opsin 4. (520 aa)
Nr1d2Uncharacterized protein. (573 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
CSNK1DCasein kinase 1 delta. (389 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (561 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
BHLHE40Basic helix-loop-helix family member e40. (411 aa)
THRAP3Thyroid hormone receptor associated protein 3. (955 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
Fbxl21pF-box domain-containing protein. (462 aa)
FBXL3F-box and leucine rich repeat protein 3. (428 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1085 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSSTOP00000030497SER_THR_PHOSPHATASE domain-containing protein. (298 aa)
PSPC1Paraspeckle component 1. (523 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
ENSSTOP00000029050Uncharacterized protein. (117 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (458 aa)
ENSSTOP00000028212NR LBD domain-containing protein. (87 aa)
CRTC1CREB regulated transcription coactivator 1. (654 aa)
NLGN1Neuroligin 1. (843 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (599 aa)
PROX1Prospero homeobox 1. (737 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (318 aa)
RORBRAR related orphan receptor B. (468 aa)
CCAR2Cell cycle and apoptosis regulator 2. (920 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (378 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (726 aa)
CRY1Cryptochrome circadian regulator 1. (609 aa)
SIRT6Sirtuin 6. (351 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
NPSNeuropeptide S. (72 aa)
PTGER3Prostaglandin E receptor 3. (388 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
PDE6BPhosphodiesterase. (855 aa)
CIPCCLOCK interacting pacemaker. (399 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
ZFHX3Zinc finger homeobox 3. (3696 aa)
FBXW11F-box and WD repeat domain containing 11. (553 aa)
LOC101972479A_deaminase domain-containing protein. (338 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
LOC101959054Uncharacterized protein. (395 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
RBM4RNA binding motif protein 4. (365 aa)
MAGEL2MAGE family member L2. (1204 aa)
FBXL6F-box and leucine rich repeat protein 6. (544 aa)
LEPRLeptin receptor. (1148 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
LOC101972772A_deaminase domain-containing protein. (352 aa)
RORCRAR related orphan receptor C. (518 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (488 aa)
ATOH7Atonal bHLH transcription factor 7. (152 aa)
LOC101960206Uncharacterized protein. (207 aa)
ADRB1Adrenoceptor beta 1. (418 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1516 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (374 aa)
FBXW7F-box and WD repeat domain containing 7. (713 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (445 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (633 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
KLF10Kruppel like factor 10. (480 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (445 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
Fbxl8F-box domain-containing protein. (374 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (962 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
CLOCKClock circadian regulator. (864 aa)
Fbxl22F-box domain-containing protein. (229 aa)
NONONon-POU domain containing octamer binding. (470 aa)
PMCHPro-melanin concentrating hormone. (165 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
NOCTNocturnin. (367 aa)
TIMELESSTimeless circadian regulator. (1147 aa)
PER3Period circadian regulator 3. (1062 aa)
SfpqRRM domain-containing protein. (351 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (356 aa)
PMLPromyelocytic leukemia. (877 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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