(36 nodes) Regulation of vascular permeability network (Ictidomys tridecemlineatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	ADM	Adrenomedullin. (188 aa)
	Tjp2	Uncharacterized protein. (1138 aa)
	UCN	Urocortin. (127 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1500 aa)
	PLVAP	Plasmalemma vesicle associated protein. (445 aa)
	DDAH1	Dimethylarginine dimethylaminohydrolase 1. (285 aa)
	CXCR2	C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	LOC101968597	C-C motif chemokine. (92 aa)
	HRH1	Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (488 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	GPR4	G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	AKAP12	A-kinase anchoring protein 12. (1646 aa)
	C2CD4C	C2 calcium dependent domain containing 4C. (422 aa)
	BMP6	Bone morphogenetic protein 6. (507 aa)
	TJP3	Tight junction protein 3; Belongs to the MAGUK family. (918 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (524 aa)
	PTP4A3	Protein tyrosine phosphatase 4A3. (173 aa)
	RAMP2	Receptor activity modifying protein 2. (177 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
	PDE2A	Phosphodiesterase. (941 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1738 aa)
	ABR	ABR activator of RhoGEF and GTPase. (871 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1197 aa)
	CAPN1	Calpain 1; Belongs to the peptidase C2 family. (743 aa)
	AMOT	Angiomotin. (1068 aa)
	PDE3A	Phosphodiesterase. (1145 aa)
	C2cd4a	Uncharacterized protein. (335 aa)
	SLIT2	Slit guidance ligand 2. (1559 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1624 aa)
	MYLK3	Myosin light chain kinase 3. (813 aa)
	CDH5	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
	ANGPT1	Angiopoietin 1. (497 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1283 aa)
	FERMT2	Fermitin family member 2. (680 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABR	TJP1	ENSSTOP00000027841	ENSSTOP00000009999	ABR activator of RhoGEF and GTPase.	Tight junction protein 1; Belongs to the MAGUK family.	0.441
ABR	TJP3	ENSSTOP00000027841	ENSSTOP00000018253	ABR activator of RhoGEF and GTPase.	Tight junction protein 3; Belongs to the MAGUK family.	0.441
ABR	Tjp2	ENSSTOP00000027841	ENSSTOP00000010030	ABR activator of RhoGEF and GTPase.	Uncharacterized protein.	0.561
ADM	RAMP2	ENSSTOP00000026896	ENSSTOP00000023997	Adrenomedullin.	Receptor activity modifying protein 2.	0.993
ANGPT1	CDH5	ENSSTOP00000007177	ENSSTOP00000005601	Angiopoietin 1.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.422
BCR	TJP1	ENSSTOP00000007608	ENSSTOP00000009999	BCR activator of RhoGEF and GTPase.	Tight junction protein 1; Belongs to the MAGUK family.	0.446
BCR	TJP3	ENSSTOP00000007608	ENSSTOP00000018253	BCR activator of RhoGEF and GTPase.	Tight junction protein 3; Belongs to the MAGUK family.	0.441
BCR	Tjp2	ENSSTOP00000007608	ENSSTOP00000010030	BCR activator of RhoGEF and GTPase.	Uncharacterized protein.	0.573
CDH5	ANGPT1	ENSSTOP00000005601	ENSSTOP00000007177	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Angiopoietin 1.	0.422
CDH5	CLDN5	ENSSTOP00000005601	ENSSTOP00000018529	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.752
CDH5	OCLN	ENSSTOP00000005601	ENSSTOP00000021853	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family.	0.606
CDH5	PTPRJ	ENSSTOP00000005601	ENSSTOP00000027990	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Protein tyrosine phosphatase receptor type J.	0.606
CDH5	TJP1	ENSSTOP00000005601	ENSSTOP00000009999	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Tight junction protein 1; Belongs to the MAGUK family.	0.725
CDH5	TJP3	ENSSTOP00000005601	ENSSTOP00000018253	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Tight junction protein 3; Belongs to the MAGUK family.	0.445
CDH5	Tjp2	ENSSTOP00000005601	ENSSTOP00000010030	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.462
CLDN5	CDH5	ENSSTOP00000018529	ENSSTOP00000005601	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.752
CLDN5	OCLN	ENSSTOP00000018529	ENSSTOP00000021853	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family.	0.960
CLDN5	PLVAP	ENSSTOP00000018529	ENSSTOP00000010982	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Plasmalemma vesicle associated protein.	0.423
CLDN5	RAMP2	ENSSTOP00000018529	ENSSTOP00000023997	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Receptor activity modifying protein 2.	0.460
CLDN5	TJP1	ENSSTOP00000018529	ENSSTOP00000009999	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 1; Belongs to the MAGUK family.	0.971