STRINGSTRING
TRAF6 TRAF6 TNFSF10 TNFSF10 IKBKB IKBKB REL REL Birc2 Birc2 ZC3HAV1 ZC3HAV1 MTDH MTDH TRIM21 TRIM21 CCDC22 CCDC22 JMJD8 JMJD8 DDX1 DDX1 DHX36 DHX36 PRKD1 PRKD1 TFRC TFRC BRD4 BRD4 LAMTOR5 LAMTOR5 CCL19 CCL19 SHARPIN SHARPIN IL1B IL1B Rnf31 Rnf31 I3LZW4_ICTTR I3LZW4_ICTTR LOC101954381 LOC101954381 RIPK1 RIPK1 EDA EDA TMEM106A TMEM106A CTH CTH TRAF5 TRAF5 LOC101965602 LOC101965602 ROR1 ROR1 IKBKG IKBKG ENSSTOP00000027615 ENSSTOP00000027615 ENSSTOP00000028641 ENSSTOP00000028641 Akap13 Akap13 ENSSTOP00000028911 ENSSTOP00000028911 TNFRSF19 TNFRSF19 ATP2C1 ATP2C1 TAB3 TAB3 ENSSTOP00000030003 ENSSTOP00000030003 MAP3K14 MAP3K14 MAP3K7 MAP3K7 LOC101955567 LOC101955567 CD36 CD36 IRAK1 IRAK1 CFLAR CFLAR PINK1 PINK1 FADD FADD TRAF3IP2 TRAF3IP2 TRIM27 TRIM27 Ikbke Ikbke ABL1 ABL1 LOC101961439 LOC101961439 I3NG54_ICTTR I3NG54_ICTTR GPRC5B GPRC5B CX3CL1 CX3CL1 CD40 CD40 CD4 CD4 TRIM6 TRIM6 TIFA TIFA S100A12 S100A12 TLR3 TLR3 LPAR1 LPAR1 DDX50 DDX50 S100A4 S100A4 CASP10 CASP10 F2RL1 F2RL1 S100A13 S100A13 ALPK1 ALPK1 C18orf32 C18orf32 ABL2 ABL2 UBD UBD BCL10 BCL10 LITAF LITAF AJUBA AJUBA TRIM62 TRIM62 CCL21 CCL21 IRF3 IRF3 EDAR EDAR TLR4 TLR4 RELA RELA RBCK1 RBCK1 TRIM13 TRIM13 NOD2 NOD2 PELI1 PELI1 LURAP1L LURAP1L TRIM32 TRIM32 NOD1 NOD1 NUP62 NUP62 INAVA INAVA TERF2IP TERF2IP TAB2 TAB2 TRIM14 TRIM14 CHUK CHUK TRIML2 TRIML2 TRIML1 TRIML1 CTNNB1 CTNNB1 ADIPOQ ADIPOQ TRIM38 TRIM38 RIPK2 RIPK2 Dhx15 Dhx15 I3MMH2_ICTTR I3MMH2_ICTTR PIM2 PIM2 TRIM68 TRIM68 CARD9 CARD9 Irak4 Irak4 MYD88 MYD88 LTBR LTBR UNC5CL UNC5CL TNF TNF PRKCE PRKCE CLEC4D CLEC4D TRAF2 TRAF2 DDX21 DDX21 TRADD TRADD CASP8 CASP8 TNFSF11 TNFSF11 TNFRSF1A TNFRSF1A TIRAP TIRAP LOC101968188 LOC101968188 HTR2B HTR2B TRIM25 TRIM25 LURAP1 LURAP1 ANKRD17 ANKRD17 CD74 CD74 LTF LTF MAP3K3 MAP3K3 EDA2R EDA2R TBK1 TBK1 TRIM8 TRIM8 F2R F2R Faslg Faslg Card11 Card11 TNIP2 TNIP2 TMEM101 TMEM101 FYN FYN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (296 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RELREL proto-oncogene, NF-kB subunit. (590 aa)
Birc2Uncharacterized protein. (611 aa)
ZC3HAV1Zinc finger CCCH-type containing, antiviral 1. (800 aa)
MTDHMetadherin. (581 aa)
TRIM21Tripartite motif containing 21. (477 aa)
CCDC22Coiled-coil domain containing 22. (628 aa)
JMJD8Jumonji domain containing 8. (256 aa)
DDX1DEAD-box helicase 1. (739 aa)
DHX36DEAH-box helicase 36. (1000 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (843 aa)
TFRCTransferrin receptor. (760 aa)
BRD4Bromodomain containing 4. (1397 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
CCL19C-C motif chemokine. (135 aa)
SHARPINSHANK associated RH domain interactor. (382 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
Rnf31Uncharacterized protein. (1071 aa)
I3LZW4_ICTTRUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (129 aa)
LOC101954381UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
TMEM106ATransmembrane protein 106A. (257 aa)
CTHCystathionine gamma-lyase. (405 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
LOC101965602Uncharacterized protein. (424 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (956 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
ENSSTOP00000027615Uncharacterized protein. (247 aa)
ENSSTOP00000028641Uncharacterized protein. (509 aa)
Akap13Uncharacterized protein. (1423 aa)
ENSSTOP00000028911UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
TNFRSF19TNF receptor superfamily member 19. (417 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (949 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
ENSSTOP00000030003Uncharacterized protein. (546 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (934 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LOC101955567Uncharacterized protein. (140 aa)
CD36CD36 molecule; Belongs to the CD36 family. (473 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
PINK1PTEN induced kinase 1. (574 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TRAF3IP2TRAF3 interacting protein 2. (476 aa)
TRIM27Tripartite motif containing 27. (513 aa)
IkbkeProtein kinase domain-containing protein. (130 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
LOC101961439TIR domain-containing protein. (1051 aa)
I3NG54_ICTTRUncharacterized protein. (91 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (411 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
CD40CD40 molecule. (284 aa)
CD4CD4 molecule. (451 aa)
TRIM6Tripartite motif containing 6. (469 aa)
TIFATRAF interacting protein with forkhead associated domain. (184 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
DDX50DExD-box helicase 50. (733 aa)
S100A4Protein S100; Belongs to the S-100 family. (101 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
S100A13S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
ALPK1Alpha kinase 1. (1226 aa)
C18orf32Chromosome 18 open reading frame 32. (76 aa)
ABL2Tyrosine-protein kinase. (1142 aa)
UBDUbiquitin D. (164 aa)
BCL10BCL10 immune signaling adaptor. (153 aa)
LITAFLipopolysaccharide induced TNF factor. (167 aa)
AJUBAAjuba LIM protein. (548 aa)
TRIM62Tripartite motif containing 62. (475 aa)
CCL21C-C motif chemokine ligand 21. (133 aa)
IRF3Interferon regulatory factor 3. (420 aa)
EDAREctodysplasin A receptor. (448 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (536 aa)
TRIM13Tripartite motif containing 13. (410 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
LURAP1LLeucine rich adaptor protein 1 like. (227 aa)
TRIM32Tripartite motif containing 32. (658 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (951 aa)
NUP62Nucleoporin 62. (520 aa)
INAVAInnate immunity activator. (675 aa)
TERF2IPTERF2 interacting protein. (396 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
TRIM14Tripartite motif containing 14. (445 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
TRIML2Tripartite motif family like 2. (415 aa)
TRIML1Tripartite motif family like 1. (473 aa)
CTNNB1Catenin beta 1. (781 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
TRIM38Tripartite motif containing 38. (475 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
Dhx15Uncharacterized protein. (795 aa)
I3MMH2_ICTTRB box-type domain-containing protein. (150 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (370 aa)
TRIM68Tripartite motif containing 68. (485 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
Irak4Interleukin 1 receptor associated kinase 4. (457 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LTBRLymphotoxin beta receptor. (435 aa)
UNC5CLUnc-5 family C-terminal like. (518 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
CLEC4DC-type lectin domain family 4 member D. (218 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
DDX21DExD-box helicase 21. (787 aa)
TRADDTNFRSF1A associated via death domain. (302 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
TIRAPTIR domain containing adaptor protein. (222 aa)
LOC101968188Ig-like domain-containing protein. (266 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
TRIM25Tripartite motif containing 25. (644 aa)
LURAP1Leucine rich adaptor protein 1. (239 aa)
ANKRD17Ankyrin repeat domain 17. (2534 aa)
CD74CD74 molecule. (279 aa)
LTFLactotransferrin; Belongs to the transferrin family. (709 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
EDA2REctodysplasin A2 receptor. (297 aa)
TBK1TANK binding kinase 1. (729 aa)
TRIM8Tripartite motif containing 8. (551 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
Card11Uncharacterized protein. (1152 aa)
TNIP2TNFAIP3 interacting protein 2. (338 aa)
TMEM101Transmembrane protein 101. (257 aa)
FYNTyrosine-protein kinase. (537 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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