STRINGSTRING
PLA2G4E PLA2G4E ALDH1L2 ALDH1L2 ABCD1 ABCD1 HEXB HEXB CRABP1 CRABP1 GDPD1 GDPD1 PLA2G10 PLA2G10 PCK2 PCK2 NUDT7 NUDT7 FAAH2 FAAH2 ACAD11 ACAD11 PLBD2 PLBD2 BCO1 BCO1 ACADSB ACADSB ACOT8 ACOT8 LOC101973579 LOC101973579 ACOX2 ACOX2 ETFB ETFB ETFA ETFA PEX13 PEX13 CEL CEL ABHD2 ABHD2 PLCG2 PLCG2 ACAT2 ACAT2 HSD17B10 HSD17B10 GBA2 GBA2 INPP5F INPP5F ANGPTL3 ANGPTL3 ETFDH ETFDH DECR2 DECR2 GLA GLA SMPDL3B SMPDL3B MGST2 MGST2 SLC25A17 SLC25A17 ACAT1 ACAT1 ECI2 ECI2 CROT CROT HAO1 HAO1 CYP2W1 CYP2W1 ACER3 ACER3 SGPL1 SGPL1 ACER1 ACER1 ENPP2 ENPP2 CYP1B1 CYP1B1 HADHB HADHB LPL LPL HADH HADH PLA2G4C PLA2G4C GDPD3 GDPD3 Pla2g4b Pla2g4b CPS1 CPS1 CYP26C1 CYP26C1 AOAH AOAH BSCL2 BSCL2 ACOX1 ACOX1 EHHADH EHHADH MGLL MGLL GALC GALC ACAA2 ACAA2 PNPLA5 PNPLA5 SMPD4 SMPD4 ACER2 ACER2 NEU2 NEU2 SLC27A4 SLC27A4 ACADS ACADS Smpd5 Smpd5 ACOT7 ACOT7 LPIN3 LPIN3 APOA5 APOA5 SCP2 SCP2 ABHD16B ABHD16B ACADL ACADL LRRN4CL LRRN4CL I3MWA1_ICTTR I3MWA1_ICTTR PNPLA4 PNPLA4 ECHDC1 ECHDC1 ASAH2 ASAH2 SLC27A2 SLC27A2 PLPP6 PLPP6 LEP LEP GPCPD1 GPCPD1 CPT2 CPT2 ACOX3 ACOX3 ABHD3 ABHD3 SRD5A3 SRD5A3 PLCB1 PLCB1 ADIPOQ ADIPOQ LIPG LIPG CYP26A1 CYP26A1 ASAH1 ASAH1 ABHD6 ABHD6 PRDX6 PRDX6 PLD2 PLD2 PCK1 PCK1 PNPLA7 PNPLA7 IVD IVD ABHD12 ABHD12 PLA2G4F PLA2G4F PLA2G4D PLA2G4D ECHS1 ECHS1 CPT1B CPT1B PNPLA3 PNPLA3 ENPP7 ENPP7 LIPI LIPI SMPD3 SMPD3 HSD17B4 HSD17B4 PLA2G15 PLA2G15 LOC101972042 LOC101972042 LCT LCT LRP1 LRP1 BDH2 BDH2 NEU1 NEU1 ECI1 ECI1 PLBD1 PLBD1 ABHD16A ABHD16A CPT1A CPT1A AIG1 AIG1 ABCD2 ABCD2 NEU3 NEU3 ILVBL ILVBL ABHD12B ABHD12B APOB APOB HADHA HADHA APOA2 APOA2 NAGA NAGA CYP26B1 CYP26B1 SIRT2 SIRT2 Nudt8 Nudt8 NAPEPLD NAPEPLD ABHD1 ABHD1 MT3 MT3 APOC3 APOC3 GM2A GM2A PPARD PPARD PNPLA1 PNPLA1 PEX2 PEX2 ADTRP ADTRP AUH AUH Smim24 Smim24 DDHD2 DDHD2 LPIN2 LPIN2 Ech1 Ech1 CPT1C CPT1C PNPLA2 PNPLA2 ABCD3 ABCD3 PEX5 PEX5 PLA2G5 PLA2G5 DAGLA DAGLA ACADVL ACADVL PNPLA8 PNPLA8 GBA3 GBA3 ENSSTOP00000027857 ENSSTOP00000027857 CRAT CRAT ECHDC2 ECHDC2 SMPD2 SMPD2 HACL1 HACL1 ENSSTOP00000030369 ENSSTOP00000030369 ACAD10 ACAD10 Nudt19 Nudt19 PEX7 PEX7 PLCB3 PLCB3 LIPC LIPC ZPBP2 ZPBP2 PLA2G4A PLA2G4A PLA2G6 PLA2G6 Hexa Hexa LYPLA2 LYPLA2 BCO2 BCO2 PLCG1 PLCG1 FAAH FAAH Lipe Lipe LIPH LIPH LOC101958596 LOC101958596 LPIN1 LPIN1 TMEM130 TMEM130 PLD1 PLD1 ABCD4 ABCD4 PLA2G7 PLA2G7 SESN2 SESN2 DECR1 DECR1 SMPD1 SMPD1 GBA GBA PNLIPRP2 PNLIPRP2 GCDH GCDH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLA2G4EPhospholipase A2. (876 aa)
ALDH1L210-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
ABCD1ATP binding cassette subfamily D member 1. (739 aa)
HEXBBeta-hexosaminidase. (538 aa)
CRABP1Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
GDPD1Glycerophosphodiester phosphodiesterase domain containing 1. (314 aa)
PLA2G10Phospholipase A(2). (148 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
NUDT7Nudix hydrolase 7. (236 aa)
FAAH2Fatty acid amide hydrolase 2. (491 aa)
ACAD11Acyl-CoA dehydrogenase family member 11. (780 aa)
PLBD2Phospholipase B-like; Putative phospholipase. (589 aa)
BCO1Beta-carotene oxygenase 1. (471 aa)
ACADSBAcyl-CoA dehydrogenase short/branched chain. (445 aa)
ACOT8Acyl-CoA thioesterase 8. (320 aa)
LOC101973579Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
ETFBElectron transfer flavoprotein subunit beta. (249 aa)
ETFAElectron transfer flavoprotein subunit alpha. (333 aa)
PEX13Peroxisomal biogenesis factor 13. (403 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (558 aa)
ABHD2Abhydrolase domain containing 2. (425 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (341 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (919 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1110 aa)
ANGPTL3Angiopoietin like 3. (455 aa)
ETFDHElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (617 aa)
DECR22,4-dienoyl-CoA reductase 2. (292 aa)
GLAAlpha-galactosidase. (427 aa)
SMPDL3BAcid sphingomyelinase-like phosphodiesterase. (456 aa)
MGST2Microsomal glutathione S-transferase 2. (153 aa)
SLC25A17Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
ECI2Enoyl-CoA delta isomerase 2. (390 aa)
CROTCarnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family. (612 aa)
HAO1Hydroxyacid oxidase 1. (370 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (490 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (268 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (915 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (473 aa)
HADHHydroxyacyl-CoA dehydrogenase. (314 aa)
PLA2G4CPhospholipase A2 group IVC. (571 aa)
GDPD3Glycerophosphodiester phosphodiesterase domain containing 3. (331 aa)
Pla2g4bPhospholipase A2. (774 aa)
CPS1Carbamoyl-phosphate synthase 1. (1500 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (518 aa)
AOAHAcyloxyacyl hydrolase. (587 aa)
BSCL2BSCL2 lipid droplet biogenesis associated, seipin. (462 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
MGLLMonoglyceride lipase. (311 aa)
GALCGalactosylceramidase. (622 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
PNPLA5Patatin like phospholipase domain containing 5. (389 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (827 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
NEU2Neuraminidase 2. (388 aa)
SLC27A4Solute carrier family 27 member 4. (643 aa)
ACADSAcyl-CoA dehydrogenase short chain. (412 aa)
Smpd5Endo/exonuclease/phosphatase domain-containing protein. (472 aa)
ACOT7Acyl-CoA thioesterase 7. (383 aa)
LPIN3Lipin 3. (841 aa)
APOA5Apolipoprotein A5. (370 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
ABHD16BAbhydrolase domain containing 16B. (466 aa)
ACADLAcyl-CoA dehydrogenase long chain. (430 aa)
LRRN4CLLRRN4 C-terminal like. (237 aa)
I3MWA1_ICTTRUncharacterized protein. (56 aa)
PNPLA4Patatin like phospholipase domain containing 4. (253 aa)
ECHDC1Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (312 aa)
ASAH2Neutral ceramidase. (716 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
PLPP6Phospholipid phosphatase 6. (294 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
GPCPD1Glycerophosphocholine phosphodiesterase 1. (668 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (645 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
ABHD3Abhydrolase domain containing 3. (338 aa)
SRD5A3Steroid 5 alpha-reductase 3. (318 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
LIPGLipase G, endothelial type. (500 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa)
ABHD6Abhydrolase domain containing 6. (337 aa)
PRDX6Peroxiredoxin 6. (224 aa)
PLD2Phospholipase. (933 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PNPLA7Patatin like phospholipase domain containing 7. (1354 aa)
IVDIsovaleryl-CoA dehydrogenase. (375 aa)
ABHD12Abhydrolase domain containing 12. (397 aa)
PLA2G4FPhospholipase A2. (840 aa)
PLA2G4DPhospholipase A2. (827 aa)
ECHS1Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PNPLA3Patatin like phospholipase domain containing 3. (420 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (427 aa)
LIPILipase I. (415 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (736 aa)
PLA2G15Phospholipase A2 group XV. (413 aa)
LOC101972042Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
LCTLactase. (1928 aa)
LRP1LDL receptor related protein 1. (4508 aa)
BDH23-hydroxybutyrate dehydrogenase 2. (245 aa)
NEU1Neuraminidase 1. (416 aa)
ECI1Enoyl-CoA delta isomerase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (243 aa)
PLBD1Phospholipase B-like; Putative phospholipase. (494 aa)
ABHD16AAbhydrolase domain containing 16A. (558 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
AIG1Androgen induced 1. (238 aa)
ABCD2ATP binding cassette subfamily D member 2. (741 aa)
NEU3Neuraminidase 3. (435 aa)
ILVBLIlvB acetolactate synthase like; Belongs to the TPP enzyme family. (632 aa)
ABHD12BAbhydrolase domain containing 12B. (359 aa)
APOBApolipoprotein B. (4482 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (791 aa)
APOA2Apolipoprotein A2. (101 aa)
NAGAAlpha-galactosidase. (423 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
Nudt8Nudix hydrolase domain-containing protein. (210 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (400 aa)
ABHD1Abhydrolase domain containing 1. (405 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
APOC3Apolipoprotein C3. (130 aa)
GM2AGM2 ganglioside activator. (192 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
PNPLA1Patatin like phospholipase domain containing 1. (515 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
ADTRPAndrogen dependent TFPI regulating protein. (219 aa)
AUHAU RNA binding methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (267 aa)
Smim24Small integral membrane protein 24. (116 aa)
DDHD2DDHD domain containing 2. (701 aa)
LPIN2Lipin 2. (866 aa)
Ech1Uncharacterized protein. (169 aa)
CPT1CCarnitine palmitoyltransferase 1C. (834 aa)
PNPLA2Patatin like phospholipase domain containing 2. (489 aa)
ABCD3ATP binding cassette subfamily D member 3. (659 aa)
PEX5Peroxisomal biogenesis factor 5. (640 aa)
PLA2G5Phospholipase A(2). (161 aa)
DAGLADiacylglycerol lipase alpha. (1042 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (655 aa)
PNPLA8Patatin like phospholipase domain containing 8. (692 aa)
GBA3Glucosylceramidase beta 3 (gene/pseudogene); Belongs to the glycosyl hydrolase 1 family. (472 aa)
ENSSTOP00000027857Uncharacterized protein. (73 aa)
CRATCarnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (626 aa)
ECHDC2Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (294 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (419 aa)
HACL12-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (499 aa)
ENSSTOP00000030369Uncharacterized protein. (353 aa)
ACAD10Acyl-CoA dehydrogenase family member 10. (1072 aa)
Nudt19Uncharacterized protein. (180 aa)
PEX7Peroxisomal biogenesis factor 7. (318 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
LIPCLipase C, hepatic type. (463 aa)
ZPBP2Zona pellucida binding protein 2. (337 aa)
PLA2G4APhospholipase A2. (750 aa)
PLA2G6Phospholipase A2 group VI. (807 aa)
HexaBeta-hexosaminidase. (527 aa)
LYPLA2Lysophospholipase 2. (231 aa)
BCO2Beta-carotene oxygenase 2. (575 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
FAAHFatty acid amide hydrolase. (579 aa)
LipeHormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (763 aa)
LIPHLipase H. (444 aa)
LOC101958596Uncharacterized protein. (231 aa)
LPIN1Lipin 1. (930 aa)
TMEM130Transmembrane protein 130. (338 aa)
PLD1Phospholipase. (1037 aa)
ABCD4ATP binding cassette subfamily D member 4. (593 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (443 aa)
SESN2Sestrin 2. (479 aa)
DECR12,4-dienoyl-CoA reductase 1. (335 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
GBAGlucosylceramidase. (516 aa)
PNLIPRP2Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (481 aa)
GCDHGlutaryl-CoA dehydrogenase. (438 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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