STRINGSTRING
STAT5B STAT5B TOMM70 TOMM70 TRIM41 TRIM41 IRAK3 IRAK3 SLAMF8 SLAMF8 PTPN2 PTPN2 TNFAIP3 TNFAIP3 Banf1 Banf1 AIM2 AIM2 MYO1F MYO1F TBK1 TBK1 Nlrc3 Nlrc3 MMP12 MMP12 GBP5 GBP5 Polr3g Polr3g DCST1 DCST1 NECTIN2 NECTIN2 XRCC6 XRCC6 CARD9 CARD9 HSP90AA1 HSP90AA1 NLRC5 NLRC5 RBM14 RBM14 PRKDC PRKDC TIRAP TIRAP TREM2 TREM2 MASP1 MASP1 VAV1 VAV1 CASP8 CASP8 CLEC12B CLEC12B DUSP10 DUSP10 ATG12 ATG12 PPARG PPARG Cfi Cfi PYCARD PYCARD PARP9 PARP9 POLR3F POLR3F SH2D1A SH2D1A Sfpq Sfpq LOC101967274 LOC101967274 Ins Ins USP27X USP27X CASP6 CASP6 TLR4 TLR4 MED1 MED1 CLNK CLNK ACOD1 ACOD1 CXorf21 CXorf21 STING1 STING1 I3N0Y5_ICTTR I3N0Y5_ICTTR MNDA MNDA TRIM56 TRIM56 IRF3 IRF3 LOC101973215 LOC101973215 CADM1 CADM1 DRD2 DRD2 TAP1 TAP1 Tap2 Tap2 I3M249_ICTTR I3M249_ICTTR TTLL12 TTLL12 VSIG4 VSIG4 METTL3 METTL3 CACTIN CACTIN COCH COCH ENSSTOP00000031571 ENSSTOP00000031571 Cgas Cgas USP15 USP15 IL21 IL21 OAS3 OAS3 LAMP1 LAMP1 DHX58 DHX58 STAT5A STAT5A IFI35 IFI35 EREG EREG DNAJA3 DNAJA3 NFE2L2 NFE2L2 ADAM8 ADAM8 CD96 CD96 LOC106144927 LOC106144927 TRIM62 TRIM62 SAMHD1 SAMHD1 LOC101964870 LOC101964870 TREX1 TREX1 LOC101957374 LOC101957374 FFAR2 FFAR2 FCN1 FCN1 WNT5A WNT5A SOCS1 SOCS1 SPI1 SPI1 YTHDF2 YTHDF2 Lyar Lyar CASP10 CASP10 HSP90AB1 HSP90AB1 TLR2 TLR2 PARP14 PARP14 RNF185 RNF185 GFER GFER MASP2 MASP2 OTOP1 OTOP1 TRIM6 TRIM6 NMI NMI I3NFC8_ICTTR I3NFC8_ICTTR LOC101975245 LOC101975245 Usp18 Usp18 LOC101961439 LOC101961439 NLRC4 NLRC4 LRP8 LRP8 Ikbke Ikbke ARRB2 ARRB2 MUL1 MUL1 TRAFD1 TRAFD1 CRK CRK FADD FADD POLR3B POLR3B LOC101955567 LOC101955567 KLRD1 KLRD1 ENSSTOP00000026236 ENSSTOP00000026236 ENSSTOP00000026473 ENSSTOP00000026473 TKFC TKFC SERPING1 SERPING1 CNOT7 CNOT7 UBE2K UBE2K PLA2G5 PLA2G5 ENSSTOP00000027114 ENSSTOP00000027114 LOC101965492 LOC101965492 LOC101966045 LOC101966045 MAVS MAVS TYRO3 TYRO3 AP1G1 AP1G1 APPL1 APPL1 Matr3 Matr3 IL12A IL12A POLR3C POLR3C APPL2 APPL2 I3MMN9_ICTTR I3MMN9_ICTTR LAG3 LAG3 NONO NONO CDC37 CDC37 STAT2 STAT2 DHX9 DHX9 ATG5 ATG5 POLR3D POLR3D HEXIM1 HEXIM1 LEP LEP AKIRIN2 AKIRIN2 SIN3A SIN3A ZNFX1 ZNFX1 RNF135 RNF135 FGR FGR TXK TXK NOD2 NOD2 TYROBP TYROBP GRN GRN DPP4 DPP4 TRIM21 TRIM21 IL12B IL12B PIK3R6 PIK3R6 IRF7 IRF7 PLCG2 PLCG2 SYK SYK TLR8 TLR8 N4BP1 N4BP1 NCF1 NCF1 XRCC5 XRCC5 RIOK3 RIOK3 I3MMH2_ICTTR I3MMH2_ICTTR ADAR ADAR KLRK1 KLRK1 SUSD4 SUSD4 LSM14A LSM14A PQBP1 PQBP1 YTHDF3 YTHDF3 SREBF1 SREBF1 ENSSTOP00000030168 ENSSTOP00000030168 NLRX1 NLRX1 PSPC1 PSPC1 HPX HPX RASGRP1 RASGRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT5BSignal transducer and activator of transcription. (765 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
TRIM41Uncharacterized protein. (628 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (607 aa)
SLAMF8SLAM family member 8. (298 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (389 aa)
TNFAIP3TNF alpha induced protein 3. (776 aa)
Banf1Uncharacterized protein. (89 aa)
AIM2Absent in melanoma 2. (349 aa)
MYO1FMyosin IF; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1070 aa)
TBK1TANK binding kinase 1. (729 aa)
Nlrc3Uncharacterized protein. (397 aa)
MMP12Matrix metallopeptidase 12. (477 aa)
GBP5Guanylate binding protein 5. (587 aa)
Polr3gDNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (224 aa)
DCST1DC-STAMP domain containing 1. (710 aa)
NECTIN2Nectin cell adhesion molecule 2. (534 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
NLRC5NLR family CARD domain containing 5. (1847 aa)
RBM14RNA binding motif protein 14. (669 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
TIRAPTIR domain containing adaptor protein. (222 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (262 aa)
MASP1Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (733 aa)
VAV1Vav guanine nucleotide exchange factor 1. (822 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
CLEC12BC-type lectin domain family 12 member B. (276 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
CfiUncharacterized protein; Belongs to the peptidase S1 family. (555 aa)
PYCARDPYD and CARD domain containing. (194 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (820 aa)
POLR3FDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (126 aa)
SfpqRRM domain-containing protein. (351 aa)
LOC101967274SERPIN domain-containing protein; Belongs to the serpin family. (375 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
USP27XUbiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (268 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
CLNKCytokine dependent hematopoietic cell linker. (423 aa)
ACOD1Aconitate decarboxylase 1. (473 aa)
CXorf21Chromosome X open reading frame 21. (298 aa)
STING1Transmembrane protein 173. (379 aa)
I3N0Y5_ICTTRC-type lectin domain-containing protein. (224 aa)
MNDAMyeloid cell nuclear differentiation antigen. (431 aa)
TRIM56Tripartite motif containing 56. (726 aa)
IRF3Interferon regulatory factor 3. (420 aa)
LOC101973215SERPIN domain-containing protein; Belongs to the serpin family. (375 aa)
CADM1Cell adhesion molecule 1. (477 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (749 aa)
Tap2Uncharacterized protein. (703 aa)
I3M249_ICTTRUncharacterized protein. (683 aa)
TTLL12Tubulin tyrosine ligase like 12. (590 aa)
VSIG4V-set and immunoglobulin domain containing 4. (399 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
CACTINCactin, spliceosome C complex subunit. (720 aa)
COCHCochlin. (550 aa)
ENSSTOP00000031571C-type lectin domain-containing protein. (138 aa)
CgasMab-21 domain-containing protein. (305 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
OAS32'-5'-oligoadenylate synthetase 3. (991 aa)
LAMP1Lysosomal associated membrane protein 1. (389 aa)
DHX58DExH-box helicase 58. (678 aa)
STAT5ASignal transducer and activator of transcription. (773 aa)
IFI35Interferon induced protein 35. (270 aa)
EREGEpiregulin. (163 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (479 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
ADAM8ADAM metallopeptidase domain 8. (818 aa)
CD96CD96 molecule. (558 aa)
LOC106144927AIG1-type G domain-containing protein. (307 aa)
TRIM62Tripartite motif containing 62. (475 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (618 aa)
LOC101964870G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (327 aa)
TREX1Three prime repair exonuclease 1. (304 aa)
LOC101957374SERPIN domain-containing protein; Belongs to the serpin family. (427 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
FCN1Ficolin 1. (336 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (588 aa)
LyarUncharacterized protein. (190 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
PARP14Poly [ADP-ribose] polymerase. (1803 aa)
RNF185Ring finger protein 185. (192 aa)
GFERSulfhydryl oxidase. (206 aa)
MASP2Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (690 aa)
OTOP1Otopetrin 1. (583 aa)
TRIM6Tripartite motif containing 6. (469 aa)
NMIN-myc and STAT interactor. (308 aa)
I3NFC8_ICTTRDNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (224 aa)
LOC101975245HATPase_c domain-containing protein. (733 aa)
Usp18USP domain-containing protein; Belongs to the peptidase C19 family. (354 aa)
LOC101961439TIR domain-containing protein. (1051 aa)
NLRC4NLR family CARD domain containing 4. (841 aa)
LRP8LDL receptor related protein 8. (940 aa)
IkbkeProtein kinase domain-containing protein. (130 aa)
ARRB2Arrestin beta 2. (409 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
TRAFD1TRAF-type zinc finger domain containing 1. (580 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
POLR3BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
LOC101955567Uncharacterized protein. (140 aa)
KLRD1Killer cell lectin like receptor D1. (178 aa)
ENSSTOP00000026236Uncharacterized protein. (74 aa)
ENSSTOP00000026473Uncharacterized protein. (344 aa)
TKFCTriokinase and FMN cyclase. (578 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (474 aa)
CNOT7Uncharacterized protein. (285 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
PLA2G5Phospholipase A(2). (161 aa)
ENSSTOP00000027114Uncharacterized protein. (91 aa)
LOC101965492Uncharacterized protein. (396 aa)
LOC101966045Uncharacterized protein. (993 aa)
MAVSMitochondrial antiviral signaling protein. (509 aa)
TYRO3TYRO3 protein tyrosine kinase. (890 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (699 aa)
Matr3Uncharacterized protein. (849 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
I3MMN9_ICTTRSERPIN domain-containing protein; Belongs to the serpin family. (417 aa)
LAG3Lymphocyte activating 3. (523 aa)
NONONon-POU domain containing octamer binding. (470 aa)
CDC37Cell division cycle 37. (378 aa)
STAT2Signal transducer and activator of transcription. (805 aa)
DHX9DExH-box helicase 9. (1328 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
POLR3DRNA polymerase III subunit D. (398 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (355 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
AKIRIN2Akirin 2. (124 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1698 aa)
RNF135Ring finger protein 135. (421 aa)
FGRTyrosine-protein kinase. (527 aa)
TXKTyrosine-protein kinase. (526 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
GRNGranulin precursor. (596 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (764 aa)
TRIM21Tripartite motif containing 21. (477 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (748 aa)
IRF7Interferon regulatory factor 7. (472 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
SYKTyrosine-protein kinase. (626 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
N4BP1NEDD4 binding protein 1. (827 aa)
NCF1Neutrophil cytosolic factor 1. (405 aa)
XRCC5X-ray repair cross complementing 5. (734 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
I3MMH2_ICTTRB box-type domain-containing protein. (150 aa)
ADARAdenosine deaminase RNA specific. (1165 aa)
KLRK1Killer cell lectin like receptor K1. (227 aa)
SUSD4Sushi domain containing 4. (489 aa)
LSM14ALSM14A mRNA processing body assembly factor. (463 aa)
PQBP1Polyglutamine binding protein 1. (265 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1152 aa)
ENSSTOP00000030168Uncharacterized protein. (76 aa)
NLRX1NLR family member X1. (975 aa)
PSPC1Paraspeckle component 1. (523 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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