STRINGSTRING
NCOR2 NCOR2 MSX2 MSX2 GATA3 GATA3 Trib2 Trib2 E2F1 E2F1 CCDC85B CCDC85B WNT1 WNT1 WNT10B WNT10B YAP1 YAP1 GATA2 GATA2 FBN1 FBN1 MMP11 MMP11 FERMT2 FERMT2 TRIB3 TRIB3 Sod2 Sod2 LRP3 LRP3 Foxo1 Foxo1 TGFB1 TGFB1 SMAD3 SMAD3 BBS12 BBS12 SORT1 SORT1 AXIN1 AXIN1 RORA RORA FLCN FLCN LRP6 LRP6 ADIPOQ ADIPOQ SIRT1 SIRT1 ZFPM2 ZFPM2 ARNTL ARNTL TGFB1I1 TGFB1I1 Ddit3 Ddit3 CCN4 CCN4 ZFPM1 ZFPM1 ASXL1 ASXL1 GPS2 GPS2 DLK1 DLK1 WNT5A WNT5A MKX MKX JDP2 JDP2 Ankrd30a Ankrd30a SIRT2 SIRT2 WNT3A WNT3A C1QL4 C1QL4 ZADH2 ZADH2 TRPV4 TRPV4 TLCD3B TLCD3B ENSSTOP00000025615 ENSSTOP00000025615 INSIG1 INSIG1 ENSSTOP00000026011 ENSSTOP00000026011 JAG1 JAG1 TRIO TRIO ENSSTOP00000028027 ENSSTOP00000028027 WWTR1 WWTR1 NUCB2 NUCB2 RUNX1T1 RUNX1T1 TCF7L2 TCF7L2 ENSSTOP00000032126 ENSSTOP00000032126 GPER1 GPER1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCOR2Nuclear receptor corepressor 2. (2447 aa)
MSX2Msh homeobox 2. (267 aa)
GATA3GATA binding protein 3. (444 aa)
Trib2Protein kinase domain-containing protein. (343 aa)
E2F1E2F transcription factor 1. (392 aa)
CCDC85BCoiled-coil domain containing 85B. (202 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
YAP1Yes associated protein 1. (397 aa)
GATA2GATA binding protein 2. (481 aa)
FBN1Fibrillin 1. (2736 aa)
MMP11Matrix metallopeptidase 11. (487 aa)
FERMT2Fermitin family member 2. (680 aa)
TRIB3Tribbles pseudokinase 3. (363 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
LRP3LDL receptor related protein 3. (750 aa)
Foxo1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (535 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BBS12Bardet-Biedl syndrome 12. (708 aa)
SORT1Sortilin. (765 aa)
AXIN1Axin 1. (869 aa)
RORARAR related orphan receptor A. (521 aa)
FLCNFolliculin. (579 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
SIRT1Sirtuin 1. (602 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1149 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (633 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (479 aa)
Ddit3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
CCN4Cellular communication network factor 4. (366 aa)
ZFPM1Zinc finger protein, FOG family member 1. (783 aa)
ASXL1ASXL transcriptional regulator 1. (1508 aa)
GPS2G protein pathway suppressor 2. (327 aa)
DLK1Delta like non-canonical Notch ligand 1. (383 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
MKXMohawk homeobox. (352 aa)
JDP2Jun dimerization protein 2. (163 aa)
Ankrd30aANK_REP_REGION domain-containing protein. (1545 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
C1QL4Complement C1q like 4. (238 aa)
ZADH2Zinc binding alcohol dehydrogenase domain containing 2. (377 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
TLCD3BTLC domain containing 3B. (276 aa)
ENSSTOP00000025615DUF3496 domain-containing protein. (484 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (254 aa)
ENSSTOP00000026011BHLH domain-containing protein. (102 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3069 aa)
ENSSTOP00000028027Protein kinase domain-containing protein. (300 aa)
WWTR1WW domain containing transcription regulator 1. (434 aa)
NUCB2Nucleobindin 2. (467 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (604 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
ENSSTOP00000032126Uncharacterized protein. (141 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (14%) [HD]