(19 nodes) Positive regulation of T-helper cell differentiation network (Ictidomys tridecemlineatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	LOC101960206	Uncharacterized protein. (207 aa)
	CCL19	C-C motif chemokine. (135 aa)
	I3M4W8_ICTTR	Uncharacterized protein. (207 aa)
	HLX	H2.0 like homeobox. (490 aa)
	MALT1	MALT1 paracaspase. (747 aa)
	I3N090_ICTTR	Uncharacterized protein. (207 aa)
	I3MVL6_ICTTR	Uncharacterized protein. (192 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	IL23A	Interleukin 23 subunit alpha. (185 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	NLRP3	NLR family pyrin domain containing 3. (1035 aa)
	MYB	MYB proto-oncogene, transcription factor. (753 aa)
	ANXA1	Annexin. (346 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	Shb	SH2 domain-containing protein. (495 aa)
	IL4R	Interleukin 4 receptor. (795 aa)
	NFKBID	NFKB inhibitor delta. (327 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	NFKBIZ	NFKB inhibitor zeta. (688 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3M4W8_ICTTR	IL23A	ENSSTOP00000004314	ENSSTOP00000014301	Uncharacterized protein.	Interleukin 23 subunit alpha.	0.709
I3M4W8_ICTTR	IL4R	ENSSTOP00000004314	ENSSTOP00000022338	Uncharacterized protein.	Interleukin 4 receptor.	0.707
I3MVL6_ICTTR	IL23A	ENSSTOP00000016161	ENSSTOP00000014301	Uncharacterized protein.	Interleukin 23 subunit alpha.	0.709
I3MVL6_ICTTR	IL4R	ENSSTOP00000016161	ENSSTOP00000022338	Uncharacterized protein.	Interleukin 4 receptor.	0.707
I3N090_ICTTR	IL23A	ENSSTOP00000017786	ENSSTOP00000014301	Uncharacterized protein.	Interleukin 23 subunit alpha.	0.709
I3N090_ICTTR	IL4R	ENSSTOP00000017786	ENSSTOP00000022338	Uncharacterized protein.	Interleukin 4 receptor.	0.707
IL18	NLRP3	ENSSTOP00000015111	ENSSTOP00000009174	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	NLR family pyrin domain containing 3.	0.491
IL23A	I3M4W8_ICTTR	ENSSTOP00000014301	ENSSTOP00000004314	Interleukin 23 subunit alpha.	Uncharacterized protein.	0.709
IL23A	I3MVL6_ICTTR	ENSSTOP00000014301	ENSSTOP00000016161	Interleukin 23 subunit alpha.	Uncharacterized protein.	0.709
IL23A	I3N090_ICTTR	ENSSTOP00000014301	ENSSTOP00000017786	Interleukin 23 subunit alpha.	Uncharacterized protein.	0.709
IL23A	IL4R	ENSSTOP00000014301	ENSSTOP00000022338	Interleukin 23 subunit alpha.	Interleukin 4 receptor.	0.870
IL23A	LOC101960206	ENSSTOP00000014301	ENSSTOP00000018530	Interleukin 23 subunit alpha.	Uncharacterized protein.	0.709
IL4R	I3M4W8_ICTTR	ENSSTOP00000022338	ENSSTOP00000004314	Interleukin 4 receptor.	Uncharacterized protein.	0.707
IL4R	I3MVL6_ICTTR	ENSSTOP00000022338	ENSSTOP00000016161	Interleukin 4 receptor.	Uncharacterized protein.	0.707
IL4R	I3N090_ICTTR	ENSSTOP00000022338	ENSSTOP00000017786	Interleukin 4 receptor.	Uncharacterized protein.	0.707
IL4R	IL23A	ENSSTOP00000022338	ENSSTOP00000014301	Interleukin 4 receptor.	Interleukin 23 subunit alpha.	0.870
IL4R	LOC101960206	ENSSTOP00000022338	ENSSTOP00000018530	Interleukin 4 receptor.	Uncharacterized protein.	0.707
IL4R	SOCS5	ENSSTOP00000022338	ENSSTOP00000021456	Interleukin 4 receptor.	Suppressor of cytokine signaling 5.	0.756
LOC101960206	IL23A	ENSSTOP00000018530	ENSSTOP00000014301	Uncharacterized protein.	Interleukin 23 subunit alpha.	0.709
LOC101960206	IL4R	ENSSTOP00000018530	ENSSTOP00000022338	Uncharacterized protein.	Interleukin 4 receptor.	0.707