(80 nodes) Negative regulation of neuron differentiation network (Ictidomys tridecemlineatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASZ1	Castor zinc finger 1. (1720 aa)
	SPAG9	Sperm associated antigen 9. (1329 aa)
	MEIS1	Meis homeobox 1. (465 aa)
	TUNAR	TCL1 upstream neural differentiation-associated RNA. (61 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (123 aa)
	APP	Amyloid beta precursor protein. (739 aa)
	PTBP1	Polypyrimidine tract binding protein 1. (557 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	PBX1	PBX homeobox 1. (430 aa)
	ENSSTOP00000026011	BHLH domain-containing protein. (102 aa)
	ENSSTOP00000025794	Uncharacterized protein. (78 aa)
	PTGER3	Prostaglandin E receptor 3. (388 aa)
	GDF11	Growth differentiation factor 11. (387 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	GLI3	GLI family zinc finger 3. (1582 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
	Foxo3	Forkhead box O3. (673 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	HES5	Hes family bHLH transcription factor 5. (141 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (234 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	POU4F2	POU domain protein. (410 aa)
	FEZF2	FEZ family zinc finger 2. (457 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	SIX3	SIX homeobox 3. (275 aa)
	FOXA2	Forkhead box A2. (463 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	PHOX2B	Paired like homeobox 2B. (252 aa)
	FOXG1	Forkhead box G1. (428 aa)
	DLX2	Distal-less homeobox 2. (329 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (715 aa)
	Dmd	Uncharacterized protein. (1255 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
	CDK5RAP2	CDK5 regulatory subunit associated protein 2. (1860 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	DIXDC1	DIX domain containing 1. (705 aa)
	HES3	Hes family bHLH transcription factor 3. (178 aa)
	ZNF536	Zinc finger protein 536. (1298 aa)
	RAP1GAP	RAP1 GTPase activating protein. (728 aa)
	Mag	Uncharacterized protein. (64 aa)
	GPR37L1	G protein-coupled receptor 37 like 1. (480 aa)
	DISP3	Dispatched RND transporter family member 3. (1244 aa)
	APBB1	Amyloid beta precursor protein binding family B member 1. (708 aa)
	ASPM	Abnormal spindle microtubule assembly. (3203 aa)
	CALR	Calreticulin. (418 aa)
	SOX8	SRY-box transcription factor 8. (466 aa)
	CTDSP1	CTD small phosphatase 1. (238 aa)
	Rest	Uncharacterized protein. (328 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
	LBX1	Ladybird homeobox 1. (281 aa)
	ISL2	ISL LIM homeobox 2. (359 aa)
	LMX1A	LIM homeobox transcription factor 1 alpha. (382 aa)
	CNTN2	Contactin 2. (1045 aa)
	Ttc3	Uncharacterized protein. (1070 aa)
	NOTCH3	Notch receptor 3. (2277 aa)
	FMR1	Fragile X mental retardation 1. (631 aa)
	PAX6	Paired box 6. (436 aa)
	NEPRO	Nucleolus and neural progenitor protein. (560 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (218 aa)
	RTN4	Reticulon. (1177 aa)
	CNTN4	Contactin 4. (1027 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	HMG20A	High mobility group 20A. (347 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E nuclear import factor 1. (967 aa)
	DDX6	DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (634 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1631 aa)
	HOXA2	Homeobox A2. (374 aa)
	IRX3	Iroquois homeobox 3. (443 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (82 aa)
	SHH	Sonic hedgehog signaling molecule. (370 aa)
	CNTF	Ciliary neurotrophic factor. (199 aa)
	DLX6	Distal-less homeobox 6. (175 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	ZHX2	Zinc fingers and homeoboxes 2. (837 aa)
	LOC101968601	Uncharacterized protein. (80 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB1	APP	ENSSTOP00000008125	ENSSTOP00000026933	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein.	0.995
APBB1	NBN	ENSSTOP00000008125	ENSSTOP00000013605	Amyloid beta precursor protein binding family B member 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.633
APP	APBB1	ENSSTOP00000026933	ENSSTOP00000008125	Amyloid beta precursor protein.	Amyloid beta precursor protein binding family B member 1.	0.995
APP	CALR	ENSSTOP00000026933	ENSSTOP00000007857	Amyloid beta precursor protein.	Calreticulin.	0.653
APP	CNTN2	ENSSTOP00000026933	ENSSTOP00000004116	Amyloid beta precursor protein.	Contactin 2.	0.834
APP	CNTN4	ENSSTOP00000026933	ENSSTOP00000000131	Amyloid beta precursor protein.	Contactin 4.	0.916
APP	FMR1	ENSSTOP00000026933	ENSSTOP00000002918	Amyloid beta precursor protein.	Fragile X mental retardation 1.	0.526
APP	Foxo3	ENSSTOP00000026933	ENSSTOP00000022009	Amyloid beta precursor protein.	Forkhead box O3.	0.522
APP	GSK3B	ENSSTOP00000026933	ENSSTOP00000023193	Amyloid beta precursor protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.634
APP	ITGB1	ENSSTOP00000026933	ENSSTOP00000012063	Amyloid beta precursor protein.	Integrin beta; Belongs to the integrin beta chain family.	0.663
APP	Mag	ENSSTOP00000026933	ENSSTOP00000008930	Amyloid beta precursor protein.	Uncharacterized protein.	0.482
APP	SHH	ENSSTOP00000026933	ENSSTOP00000015201	Amyloid beta precursor protein.	Sonic hedgehog signaling molecule.	0.682
APP	Ttc3	ENSSTOP00000026933	ENSSTOP00000003881	Amyloid beta precursor protein.	Uncharacterized protein.	0.690
ASCL1	DLX2	ENSSTOP00000021479	ENSSTOP00000018531	Achaete-scute family bHLH transcription factor 1.	Distal-less homeobox 2.	0.445
ASCL1	DLX6	ENSSTOP00000021479	ENSSTOP00000015333	Achaete-scute family bHLH transcription factor 1.	Distal-less homeobox 6.	0.464
ASCL1	ENSSTOP00000026011	ENSSTOP00000021479	ENSSTOP00000026011	Achaete-scute family bHLH transcription factor 1.	BHLH domain-containing protein.	0.628
ASCL1	FOXG1	ENSSTOP00000021479	ENSSTOP00000018836	Achaete-scute family bHLH transcription factor 1.	Forkhead box G1.	0.408
ASCL1	HES1	ENSSTOP00000021479	ENSSTOP00000020051	Achaete-scute family bHLH transcription factor 1.	Hes family bHLH transcription factor 1.	0.638
ASCL1	HES5	ENSSTOP00000021479	ENSSTOP00000021535	Achaete-scute family bHLH transcription factor 1.	Hes family bHLH transcription factor 5.	0.417
ASCL1	ID2	ENSSTOP00000021479	ENSSTOP00000021575	Achaete-scute family bHLH transcription factor 1.	Inhibitor of DNA binding 2.	0.489