(35 nodes) Positive regulation of cyclin-dependent protein serine/threonine kinase activity network (Ictidomys tridecemlineatus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	Cks2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	CCND1	Cyclin D1. (250 aa)
	LOC101963097	Uncharacterized protein. (243 aa)
	PSMD10	ANK_REP_REGION domain-containing protein. (226 aa)
	Pkd2	EF-hand domain-containing protein. (892 aa)
	ADAM17	ADAM metallopeptidase domain 17. (811 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
	CDK5RAP1	CDK5 regulatory subunit associated protein 1. (587 aa)
	EGFR	Receptor protein-tyrosine kinase. (1192 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	CCNT2	Cyclin T2; Belongs to the cyclin family. (728 aa)
	CCNY	Cyclin Y; Belongs to the cyclin family. (341 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4252 aa)
	STIL	STIL centriolar assembly protein. (1285 aa)
	MAPRE3	Microtubule associated protein RP/EB family member 3. (281 aa)
	CCNYL1	Cyclin Y like 1; Belongs to the cyclin family. (340 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	Ccnd2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (288 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
	SPDYA	Speedy/RINGO cell cycle regulator family member A. (312 aa)
	LOC101961074	Uncharacterized protein. (295 aa)
	LOC101961406	Uncharacterized protein. (172 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (367 aa)
	RGCC	Regulator of cell cycle. (161 aa)
	MNAT1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (292 aa)
	CCNT1	Cyclin T1; Belongs to the cyclin family. (726 aa)
	ENSSTOP00000024401	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (68 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (58 aa)
	PSRC1	Proline and serine rich coiled-coil 1. (326 aa)
	ENSSTOP00000026404	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (94 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	CCNK	Cyclin K; Belongs to the cyclin family. (582 aa)
	ENSSTOP00000031690	ANK_REP_REGION domain-containing protein. (189 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	CCND1	ENSSTOP00000028457	ENSSTOP00000000365	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin D1.	0.628
AKT1	CCND3	ENSSTOP00000028457	ENSSTOP00000023402	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin D3; Belongs to the cyclin family.	0.444
AKT1	CDKN1B	ENSSTOP00000028457	ENSSTOP00000015094	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1B.	0.975
AKT1	EGFR	ENSSTOP00000028457	ENSSTOP00000006038	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.528
AKT1	PDGFB	ENSSTOP00000028457	ENSSTOP00000019197	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.478
CCND1	AKT1	ENSSTOP00000000365	ENSSTOP00000028457	Cyclin D1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.628
CCND1	CCND3	ENSSTOP00000000365	ENSSTOP00000023402	Cyclin D1.	Cyclin D3; Belongs to the cyclin family.	0.860
CCND1	CDKN1B	ENSSTOP00000000365	ENSSTOP00000015094	Cyclin D1.	Cyclin dependent kinase inhibitor 1B.	0.996
CCND1	CKS1B	ENSSTOP00000000365	ENSSTOP00000024868	Cyclin D1.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.726
CCND1	Ccnd2	ENSSTOP00000000365	ENSSTOP00000016027	Cyclin D1.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.858
CCND1	Cks2	ENSSTOP00000000365	ENSSTOP00000000041	Cyclin D1.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.690
CCND1	EGFR	ENSSTOP00000000365	ENSSTOP00000006038	Cyclin D1.	Receptor protein-tyrosine kinase.	0.554
CCND1	ENSSTOP00000024401	ENSSTOP00000000365	ENSSTOP00000024401	Cyclin D1.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.690
CCND1	ENSSTOP00000026404	ENSSTOP00000000365	ENSSTOP00000026404	Cyclin D1.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.690
CCND1	LOC101961074	ENSSTOP00000000365	ENSSTOP00000020185	Cyclin D1.	Uncharacterized protein.	0.673
CCND1	MNAT1	ENSSTOP00000000365	ENSSTOP00000021783	Cyclin D1.	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.	0.538
CCND3	AKT1	ENSSTOP00000023402	ENSSTOP00000028457	Cyclin D3; Belongs to the cyclin family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.444
CCND3	CCND1	ENSSTOP00000023402	ENSSTOP00000000365	Cyclin D3; Belongs to the cyclin family.	Cyclin D1.	0.860
CCND3	CDKN1B	ENSSTOP00000023402	ENSSTOP00000015094	Cyclin D3; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 1B.	0.995
CCND3	CKS1B	ENSSTOP00000023402	ENSSTOP00000024868	Cyclin D3; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.711