STRINGSTRING
Hif1a Hif1a NFE2L2 NFE2L2 RTN4 RTN4 ACVRL1 ACVRL1 Brca1 Brca1 S100A1 S100A1 SERPINE1 SERPINE1 RAPGEF3 RAPGEF3 VASH2 VASH2 THBS1 THBS1 ITGB2 ITGB2 CYP1B1 CYP1B1 CCR2 CCR2 RRAS RRAS IL1B IL1B VEGFC VEGFC SFRP2 SFRP2 HK2 HK2 SEMA5A SEMA5A Itgb3 Itgb3 LRG1 LRG1 HGF HGF ANGPT2 ANGPT2 PRKCA PRKCA ITGAX ITGAX CXCL8 CXCL8 PRKD1 PRKD1 ADAM12 ADAM12 JMJD8 JMJD8 Xbp1 Xbp1 GRN GRN F3 F3 CCL24 CCL24 ANGPTL3 ANGPTL3 MTDH MTDH EPHA1 EPHA1 PIK3R6 PIK3R6 TIE1 TIE1 SP1 SP1 GATA2 GATA2 CDH5 CDH5 CXCR4 CXCR4 MMP9 MMP9 IL10 IL10 VEGFD VEGFD STAT3 STAT3 HPSE HPSE ITGA5 ITGA5 AGO2 AGO2 C6 C6 ENG ENG ECM1 ECM1 CXCR3 CXCR3 VEGFA VEGFA HSPB6 HSPB6 CELA1 CELA1 LOC101962660 LOC101962660 MYDGF MYDGF BMPER BMPER TNFRSF1A TNFRSF1A AKT3 AKT3 SMAD1 SMAD1 TNN TNN TJP1 TJP1 EMC10 EMC10 PLCG1 PLCG1 FUT1 FUT1 PRKCB PRKCB DDAH1 DDAH1 NODAL NODAL PDPK1 PDPK1 WARS2 WARS2 CXCR2 CXCR2 C5 C5 CTSH CTSH ISL1 ISL1 ITGB1 ITGB1 NRP1 NRP1 PXN PXN VEGFB VEGFB Rhob Rhob SLC39A12 SLC39A12 CAMP CAMP ERAP1 ERAP1 CHI3L1 CHI3L1 Aqp1 Aqp1 GHSR GHSR KDR KDR HYAL1 HYAL1 ITGB8 ITGB8 LOC101965906 LOC101965906 SHH SHH SIRT1 SIRT1 Fgf2 Fgf2 MDK MDK I3MV62_ICTTR I3MV62_ICTTR LOC101955809 LOC101955809 GAB1 GAB1 EMILIN1 EMILIN1 Notch4 Notch4 FLT1 FLT1 CD34 CD34 EMP2 EMP2 DLL1 DLL1 Znf304 Znf304 GATA6 GATA6 I3N2R3_ICTTR I3N2R3_ICTTR TERT TERT HSPB1 HSPB1 PTGIS PTGIS JAK1 JAK1 LOC101974597 LOC101974597 NINJ1 NINJ1 TBXA2R TBXA2R PGF PGF WNT5A WNT5A ANGPT4 ANGPT4 LOC101956215 LOC101956215 CCR3 CCR3 ANXA3 ANXA3 ZC3H12A ZC3H12A EMILIN2 EMILIN2 JCAD JCAD SPHK1 SPHK1 FGF1 FGF1 CX3CR1 CX3CR1 GREM1 GREM1 APLNR APLNR TLR3 TLR3 FGF18 FGF18 Aggf1 Aggf1 Pdcl3 Pdcl3 CYBB CYBB GDF2 GDF2 LGALS3 LGALS3 CD40 CD40 C5AR1 C5AR1 Hmga2 Hmga2 Gata4 Gata4 GHRL GHRL C3AR1 C3AR1 RAMP2 RAMP2 ENSSTOP00000024694 ENSSTOP00000024694 LOC101968118 LOC101968118 TGFBR2 TGFBR2 Apela Apela SIRT6 SIRT6 LOC101962934 LOC101962934 HMOX1 HMOX1 SMOC2 SMOC2 ADM ADM PDCD6 PDCD6 STIM1 STIM1 CCBE1 CCBE1 ADM2 ADM2 ENSSTOP00000027930 ENSSTOP00000027930 ADD1 ADD1 JUP JUP ETS1 ETS1 ENSSTOP00000029050 ENSSTOP00000029050 Pik3cd Pik3cd PTK2B PTK2B TEK TEK NOS3 NOS3 PKM PKM SASH1 SASH1 NR2E1 NR2E1 PRKD2 PRKD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Hif1aUncharacterized protein. (821 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
RTN4Reticulon. (1177 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
Brca1Uncharacterized protein. (353 aa)
S100A1Protein S100; Belongs to the S-100 family. (94 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (898 aa)
VASH2Vasohibin 2. (355 aa)
THBS1Thrombospondin 1. (1182 aa)
ITGB2Integrin beta. (769 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
RRASRAS related. (218 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (417 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
HK2Hexokinase 2. (917 aa)
SEMA5ASemaphorin 5A. (1074 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
ANGPT2Angiopoietin 2. (495 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1171 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (843 aa)
ADAM12ADAM metallopeptidase domain 12. (840 aa)
JMJD8Jumonji domain containing 8. (256 aa)
Xbp1BZIP domain-containing protein. (351 aa)
GRNGranulin precursor. (596 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (293 aa)
CCL24C-C motif chemokine. (119 aa)
ANGPTL3Angiopoietin like 3. (455 aa)
MTDHMetadherin. (581 aa)
EPHA1EPH receptor A1. (978 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (748 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
SP1Sp1 transcription factor. (788 aa)
GATA2GATA binding protein 2. (481 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
MMP9Matrix metallopeptidase 9. (667 aa)
IL10Interleukin 10. (178 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (359 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
HPSEHeparanase. (539 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (862 aa)
C6Complement C6. (920 aa)
ENGEndoglin. (463 aa)
ECM1Extracellular matrix protein 1. (544 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (162 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (266 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
MYDGFMyeloid derived growth factor. (165 aa)
BMPERBMP binding endothelial regulator. (685 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TNNTenascin N. (1561 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1738 aa)
EMC10ER membrane protein complex subunit 10. (223 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (378 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (285 aa)
NODALNodal growth differentiation factor. (350 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
WARS2Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (360 aa)
CXCR2C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
C5Complement C5. (1643 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (424 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (184 aa)
RhobUncharacterized protein. (196 aa)
SLC39A12Solute carrier family 39 member 12. (692 aa)
CAMPCathelicidin antimicrobial peptide. (171 aa)
ERAP1Aminopeptidase. (938 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (382 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
HYAL1Hyaluronidase. (449 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
SIRT1Sirtuin 1. (602 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
MDKMidkine. (143 aa)
I3MV62_ICTTRPhosducin domain-containing protein. (198 aa)
LOC101955809Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1335 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
EMILIN1Elastin microfibril interfacer 1. (1017 aa)
Notch4Uncharacterized protein. (1955 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
CD34CD34 molecule. (382 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (715 aa)
Znf304Zinc finger protein 304. (616 aa)
GATA6GATA binding protein 6. (593 aa)
I3N2R3_ICTTRL-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (376 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1079 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (202 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (414 aa)
JAK1Tyrosine-protein kinase. (1142 aa)
LOC101974597L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (341 aa)
NINJ1Ninjurin 1. (127 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
ANGPT4Angiopoietin 4. (496 aa)
LOC101956215Uncharacterized protein. (195 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ANXA3Annexin. (323 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
EMILIN2Elastin microfibril interfacer 2. (1085 aa)
JCADJunctional cadherin 5 associated. (1363 aa)
SPHK1Sphingosine kinase 1. (385 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
GREM1Gremlin. (184 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Aggf1Uncharacterized protein. (717 aa)
Pdcl3Phosducin domain-containing protein. (240 aa)
CYBBCytochrome b-245 beta chain. (549 aa)
GDF2Growth differentiation factor 2. (429 aa)
LGALS3Galectin. (220 aa)
CD40CD40 molecule. (284 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
Hmga2Uncharacterized protein. (109 aa)
Gata4GATA-type domain-containing protein. (212 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (484 aa)
RAMP2Receptor activity modifying protein 2. (177 aa)
ENSSTOP00000024694Uncharacterized protein. (158 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ApelaUncharacterized protein. (54 aa)
SIRT6Sirtuin 6. (351 aa)
LOC101962934Anti_prolifrtn domain-containing protein. (137 aa)
HMOX1Heme oxygenase 1. (288 aa)
SMOC2SPARC related modular calcium binding 2. (446 aa)
ADMAdrenomedullin. (188 aa)
PDCD6Programmed cell death 6. (191 aa)
STIM1Stromal interaction molecule 1. (716 aa)
CCBE1Collagen and calcium binding EGF domains 1. (290 aa)
ADM2Adrenomedullin 2. (150 aa)
ENSSTOP00000027930Uncharacterized protein. (173 aa)
ADD1Adducin 1. (764 aa)
JUPJunction plakoglobin. (780 aa)
ETS1ETS proto-oncogene 1, transcription factor. (441 aa)
ENSSTOP00000029050Uncharacterized protein. (117 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
SASH1SAM and SH3 domain containing 1. (1252 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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