(60 nodes) Negative regulation of innate immune response network (Ictidomys tridecemlineatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRAK3	Interleukin 1 receptor associated kinase 3. (607 aa)
	ENSSTOP00000031571	C-type lectin domain-containing protein. (138 aa)
	USP15	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
	NLRX1	NLR family member X1. (975 aa)
	ENSSTOP00000030168	Uncharacterized protein. (76 aa)
	YTHDF3	YTH N6-methyladenosine RNA binding protein 3. (588 aa)
	SUSD4	Sushi domain containing 4. (489 aa)
	ENSSTOP00000027114	Uncharacterized protein. (91 aa)
	CNOT7	Uncharacterized protein. (285 aa)
	SERPING1	Serpin family G member 1; Belongs to the serpin family. (474 aa)
	ENSSTOP00000026236	Uncharacterized protein. (74 aa)
	KLRD1	Killer cell lectin like receptor D1. (178 aa)
	CRK	CRK proto-oncogene, adaptor protein. (305 aa)
	TRAFD1	TRAF-type zinc finger domain containing 1. (580 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	ARRB2	Arrestin beta 2. (409 aa)
	Usp18	USP domain-containing protein; Belongs to the peptidase C19 family. (354 aa)
	NMI	N-myc and STAT interactor. (308 aa)
	OTOP1	Otopetrin 1. (583 aa)
	GFER	Sulfhydryl oxidase. (206 aa)
	PARP14	Poly [ADP-ribose] polymerase. (1803 aa)
	Lyar	Uncharacterized protein. (190 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (588 aa)
	LOC101957374	SERPIN domain-containing protein; Belongs to the serpin family. (427 aa)
	TREX1	Three prime repair exonuclease 1. (304 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (618 aa)
	LOC101973215	SERPIN domain-containing protein; Belongs to the serpin family. (375 aa)
	ACOD1	Aconitate decarboxylase 1. (473 aa)
	Ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	STAT2	Signal transducer and activator of transcription. (805 aa)
	TYRO3	TYRO3 protein tyrosine kinase. (890 aa)
	I3MMN9_ICTTR	SERPIN domain-containing protein; Belongs to the serpin family. (417 aa)
	ADAR	Adenosine deaminase RNA specific. (1165 aa)
	LOC101967274	SERPIN domain-containing protein; Belongs to the serpin family. (375 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	DUSP10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
	CLEC12B	C-type lectin domain family 12 member B. (276 aa)
	NLRC5	NLR family CARD domain containing 5. (1847 aa)
	DCST1	DC-STAMP domain containing 1. (710 aa)
	MMP12	Matrix metallopeptidase 12. (477 aa)
	Nlrc3	Uncharacterized protein. (397 aa)
	Banf1	Uncharacterized protein. (89 aa)
	TNFAIP3	TNF alpha induced protein 3. (776 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (389 aa)
	SLAMF8	SLAM family member 8. (298 aa)
	DHX58	DExH-box helicase 58. (678 aa)
	TRIM21	Tripartite motif containing 21. (477 aa)
	GRN	Granulin precursor. (596 aa)
	CD96	CD96 molecule. (558 aa)
	OAS3	2'-5'-oligoadenylate synthetase 3. (991 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	TAP1	Transporter 1, ATP binding cassette subfamily B member. (749 aa)
	Tap2	Uncharacterized protein. (703 aa)
	TTLL12	Tubulin tyrosine ligase like 12. (590 aa)
	VSIG4	V-set and immunoglobulin domain containing 4. (399 aa)
	METTL3	Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (720 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (479 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	NLRC5	ENSSTOP00000012687	ENSSTOP00000008773	Adenosine deaminase RNA specific.	NLR family CARD domain containing 5.	0.481
ADAR	OAS3	ENSSTOP00000012687	ENSSTOP00000003548	Adenosine deaminase RNA specific.	2'-5'-oligoadenylate synthetase 3.	0.413
ADAR	SAMHD1	ENSSTOP00000012687	ENSSTOP00000019357	Adenosine deaminase RNA specific.	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	0.515
ADAR	STAT2	ENSSTOP00000012687	ENSSTOP00000014314	Adenosine deaminase RNA specific.	Signal transducer and activator of transcription.	0.517
ARRB2	DRD2	ENSSTOP00000024096	ENSSTOP00000003194	Arrestin beta 2.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.957
ARRB2	USP15	ENSSTOP00000024096	ENSSTOP00000031067	Arrestin beta 2.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.479
ATG12	ATG5	ENSSTOP00000010542	ENSSTOP00000014775	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	DHX58	ENSSTOP00000010542	ENSSTOP00000005836	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExH-box helicase 58.	0.830
ATG12	NLRC5	ENSSTOP00000010542	ENSSTOP00000008773	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family CARD domain containing 5.	0.529
ATG12	NLRX1	ENSSTOP00000010542	ENSSTOP00000030193	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.726
ATG12	Nlrc3	ENSSTOP00000010542	ENSSTOP00000007521	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Uncharacterized protein.	0.516
ATG5	ATG12	ENSSTOP00000014775	ENSSTOP00000010542	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	DHX58	ENSSTOP00000014775	ENSSTOP00000005836	Autophagy protein 5; Involved in autophagic vesicle formation.	DExH-box helicase 58.	0.829
ATG5	NLRC5	ENSSTOP00000014775	ENSSTOP00000008773	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family CARD domain containing 5.	0.525
ATG5	NLRX1	ENSSTOP00000014775	ENSSTOP00000030193	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.764
ATG5	Nlrc3	ENSSTOP00000014775	ENSSTOP00000007521	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.525
CNOT7	YTHDF2	ENSSTOP00000026570	ENSSTOP00000021624	Uncharacterized protein.	YTH N6-methyladenosine RNA binding protein 2.	0.595
CNOT7	YTHDF3	ENSSTOP00000026570	ENSSTOP00000028672	Uncharacterized protein.	YTH N6-methyladenosine RNA binding protein 3.	0.595
DHX58	ATG12	ENSSTOP00000005836	ENSSTOP00000010542	DExH-box helicase 58.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.830
DHX58	ATG5	ENSSTOP00000005836	ENSSTOP00000014775	DExH-box helicase 58.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.829