STRINGSTRING
EREG EREG SPHK1 SPHK1 RGCC RGCC HOXA13 HOXA13 PDGFRB PDGFRB TGFA TGFA FGF8 FGF8 CDC16 CDC16 IGF1 IGF1 NUP62 NUP62 Anapc11 Anapc11 CDT1 CDT1 CUL3 CUL3 BTC BTC SMPD3 SMPD3 EDN3 EDN3 LRP5 LRP5 ANAPC7 ANAPC7 IGF1R IGF1R PDGFB PDGFB MET MET IGF2 IGF2 CD28 CD28 MAD2L1BP MAD2L1BP Ins Ins NSMCE2 NSMCE2 CENPE CENPE DRD3 DRD3 DMRT1 DMRT1 ANAPC5 ANAPC5 Nusap1 Nusap1 CDC27 CDC27 CDC23 CDC23 SH2B1 SH2B1 EPGN EPGN IL1B IL1B IL1A IL1A INSR INSR Prap1 Prap1 RB1 RB1 EDN1 EDN1 PHIP PHIP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EREGEpiregulin. (163 aa)
SPHK1Sphingosine kinase 1. (385 aa)
RGCCRegulator of cell cycle. (161 aa)
HOXA13Homeobox A13. (216 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
TGFATransforming growth factor alpha. (159 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CDC16Cell division cycle 16. (614 aa)
IGF1Insulin like growth factor 1. (166 aa)
NUP62Nucleoporin 62. (520 aa)
Anapc11RING-type domain-containing protein. (84 aa)
CDT1Chromatin licensing and DNA replication factor 1. (473 aa)
CUL3Cullin 3; Belongs to the cullin family. (776 aa)
BTCBetacellulin. (143 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
EDN3Endothelin 3. (197 aa)
LRP5Uncharacterized protein. (1516 aa)
ANAPC7Anaphase promoting complex subunit 7. (581 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
IGF2Insulin like growth factor 2. (180 aa)
CD28CD28 molecule. (221 aa)
MAD2L1BPMAD2L1 binding protein. (263 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (247 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2651 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (445 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (371 aa)
ANAPC5Anaphase promoting complex subunit 5. (691 aa)
Nusap1Uncharacterized protein. (416 aa)
CDC27Cell division cycle 27. (848 aa)
CDC23Cell division cycle 23. (599 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
EPGNEpithelial mitogen. (153 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
Prap1Uncharacterized protein. (145 aa)
RB1RB transcriptional corepressor 1. (957 aa)
EDN1Endothelin 1. (202 aa)
PHIPPleckstrin homology domain interacting protein. (1777 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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