STRINGSTRING
INSR INSR PLCD1 PLCD1 ZBTB20 ZBTB20 STK11 STK11 GCK GCK HTR2A HTR2A AKT2 AKT2 PTH1R PTH1R Hif1a Hif1a GCG GCG C1QTNF2 C1QTNF2 SLC45A3 SLC45A3 PTPN2 PTPN2 DDB1 DDB1 SLC25A12 SLC25A12 DYRK2 DYRK2 Foxo1 Foxo1 ACTN3 ACTN3 P2RX7 P2RX7 GPT GPT PRKAA2 PRKAA2 PPARA PPARA NFKB1 NFKB1 POU1F1 POU1F1 DGAT2 DGAT2 PRKCE PRKCE ADCYAP1R1 ADCYAP1R1 RGN RGN PPP1R3D PPP1R3D SIRT1 SIRT1 EPM2AIP1 EPM2AIP1 PPP1R3G PPP1R3G P2RY6 P2RY6 Ins Ins AVPR1B AVPR1B I3MZU0_ICTTR I3MZU0_ICTTR PRXL2C PRXL2C IRS1 IRS1 MLXIPL MLXIPL IGF2 IGF2 PTGER4 PTGER4 PDGFB PDGFB PTH PTH P2RY1 P2RY1 PPP4R3A PPP4R3A PPP4R3B PPP4R3B ESRRB ESRRB Lhcgr Lhcgr PRKAA1 PRKAA1 Arpp19 Arpp19 SORBS1 SORBS1 GPLD1 GPLD1 PSEN1 PSEN1 APP APP HNF4A HNF4A PPP1R3E PPP1R3E MAS1 MAS1 SLC4A4 SLC4A4 AKT1 AKT1 Supt20h Supt20h ENSSTOP00000029141 ENSSTOP00000029141 IGF1 IGF1 WDR5 WDR5 ENSSTOP00000031296 ENSSTOP00000031296 TCF7L2 TCF7L2 KAT2A KAT2A GPER1 GPER1 SNCA SNCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INSRTyrosine-protein kinase receptor. (1359 aa)
PLCD1Phosphoinositide phospholipase C. (756 aa)
ZBTB20Zinc finger and BTB domain containing 20. (744 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
GCKPhosphotransferase. (467 aa)
HTR2A5-hydroxytryptamine receptor 2A. (472 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
Hif1aUncharacterized protein. (821 aa)
GCGGlucagon. (180 aa)
C1QTNF2C1q and TNF related 2. (320 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (389 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
SLC25A12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
Foxo1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (535 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (900 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
POU1F1POU domain protein. (317 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (480 aa)
RGNRegucalcin. (299 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (284 aa)
SIRT1Sirtuin 1. (602 aa)
EPM2AIP1EPM2A interacting protein 1. (608 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (334 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
I3MZU0_ICTTRLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (138 aa)
PRXL2CPeroxiredoxin like 2C. (195 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
MLXIPLMLX interacting protein like. (817 aa)
IGF2Insulin like growth factor 2. (180 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (488 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. (115 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
PPP4R3AProtein phosphatase 4 regulatory subunit 3A. (820 aa)
PPP4R3BProtein phosphatase 4 regulatory subunit 3B. (820 aa)
ESRRBEstrogen related receptor beta. (454 aa)
LhcgrLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
Arpp19Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (246 aa)
SORBS1Sorbin and SH3 domain containing 1. (931 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (896 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
APPAmyloid beta precursor protein. (739 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (282 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (324 aa)
SLC4A4Anion exchange protein. (1094 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Supt20hUncharacterized protein. (200 aa)
ENSSTOP00000029141Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (109 aa)
IGF1Insulin like growth factor 1. (166 aa)
WDR5WD repeat domain 5. (384 aa)
ENSSTOP00000031296Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (112 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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