STRINGSTRING
CDKN2B CDKN2B FGFR3 FGFR3 RINT1 RINT1 RBL2 RBL2 Plk5 Plk5 APC APC RPS27L RPS27L HASPIN HASPIN XPC XPC Cacnb4 Cacnb4 BRINP3 BRINP3 TOM1L2 TOM1L2 Inhba Inhba EZH2 EZH2 FHL1 FHL1 ENSSTOP00000028143 ENSSTOP00000028143 ENSSTOP00000028075 ENSSTOP00000028075 FZR1 FZR1 LOC101966497 LOC101966497 TOPBP1 TOPBP1 ENSSTOP00000027930 ENSSTOP00000027930 CDK1 CDK1 ENSSTOP00000027725 ENSSTOP00000027725 HNF4A HNF4A ENSSTOP00000027042 ENSSTOP00000027042 FOXN3 FOXN3 MFSD11 MFSD11 INIP INIP LOC101962169 LOC101962169 Zfyve19 Zfyve19 Stk33 Stk33 LOC101962934 LOC101962934 ENSSTOP00000025631 ENSSTOP00000025631 ENSSTOP00000025460 ENSSTOP00000025460 FAM107A FAM107A ENSSTOP00000024694 ENSSTOP00000024694 MRE11 MRE11 PTPN3 PTPN3 AVEN AVEN SLC9A3R1 SLC9A3R1 I3NHC9_ICTTR I3NHC9_ICTTR DACT1 DACT1 MIIP MIIP BTG2 BTG2 Hmga2 Hmga2 RAD9A RAD9A FOXO4 FOXO4 BRD7 BRD7 MAD2L1 MAD2L1 Bub3 Bub3 CLSPN CLSPN CTDSP2 CTDSP2 ANGEL2 ANGEL2 RGCC RGCC I3NB72_ICTTR I3NB72_ICTTR RBL1 RBL1 NOP53 NOP53 NAE1 NAE1 NACC2 NACC2 KANK2 KANK2 CDC73 CDC73 TP53 TP53 TREX1 TREX1 CDKN1A CDKN1A BRCC3 BRCC3 HECA HECA FAM122A FAM122A I3N2F3_ICTTR I3N2F3_ICTTR FBXO7 FBXO7 I3N0J6_ICTTR I3N0J6_ICTTR CDC14B CDC14B SYF2 SYF2 LOC101962206 LOC101962206 GJC2 GJC2 ZFP36L2 ZFP36L2 HUS1 HUS1 IER3 IER3 JADE1 JADE1 CENPE CENPE MBD4 MBD4 BRSK2 BRSK2 CDK2AP2 CDK2AP2 TAOK3 TAOK3 BCL2 BCL2 CHFR CHFR PTEN PTEN TRIM35 TRIM35 FBXO5 FBXO5 CDKN1B CDKN1B PRMT2 PRMT2 CTNNB1 CTNNB1 TRIP13 TRIP13 NABP2 NABP2 ORC1 ORC1 CEP192 CEP192 NBN NBN TAOK2 TAOK2 Mdm2 Mdm2 RAD21 RAD21 TAOK1 TAOK1 ATF2 ATF2 TPR TPR ZC3H12D ZC3H12D FANCD2 FANCD2 PIDD1 PIDD1 WAC WAC MEIOC MEIOC Mrnip Mrnip PML PML DTL DTL Nabp1 Nabp1 YTHDC2 YTHDC2 CHMP4C CHMP4C TNF TNF Vps4a Vps4a BMP7 BMP7 BABAM2 BABAM2 SDE2 SDE2 Klhl22 Klhl22 PLK1 PLK1 CRLF3 CRLF3 FBXO31 FBXO31 Tom1l1 Tom1l1 RAD9B RAD9B BRINP2 BRINP2 CHEK2 CHEK2 GIGYF2 GIGYF2 LRRC1 LRRC1 FZD3 FZD3 Btg3 Btg3 RFWD3 RFWD3 PINX1 PINX1 PRKDC PRKDC ZFP36L1 ZFP36L1 ZWILCH ZWILCH Bub1b Bub1b BTG4 BTG4 TIPIN TIPIN EME1 EME1 ZW10 ZW10 MTBP MTBP DONSON DONSON NEK11 NEK11 Babam1 Babam1 GPNMB GPNMB CTDSP1 CTDSP1 ZNF655 ZNF655 ABRAXAS1 ABRAXAS1 E2F7 E2F7 MSH2 MSH2 DCUN1D3 DCUN1D3 EGFR EGFR PLK3 PLK3 Gpr132 Gpr132 CDK5RAP3 CDK5RAP3 I3M7E8_ICTTR I3M7E8_ICTTR NLE1 NLE1 ZNF830 ZNF830 BRSK1 BRSK1 MYO16 MYO16 BRINP1 BRINP1 CASP2 CASP2 BLM BLM RAD17 RAD17 CDC6 CDC6 ACVR1 ACVR1 ATM ATM RPA2 RPA2 USP47 USP47 C10orf90 C10orf90 FGFR2 FGFR2 Pkd2 Pkd2 SCRIB SCRIB MUS81 MUS81 OVOL1 OVOL1 NME6 NME6 CHEK1 CHEK1 PSMG2 PSMG2 TRIM39 TRIM39 CTDSPL CTDSPL BMP4 BMP4 KNTC1 KNTC1 Prap1 Prap1 EME2 EME2 RB1 RB1 Znf207 Znf207 INTS3 INTS3 Brca1 Brca1 CCND1 CCND1 CCNG1 CCNG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN2BCyclin dependent kinase inhibitor 2B. (162 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
RINT1RAD50 interactor 1. (792 aa)
RBL2RB transcriptional corepressor like 2. (1161 aa)
Plk5Uncharacterized protein. (608 aa)
APCAPC regulator of WNT signaling pathway. (2865 aa)
RPS27L40S ribosomal protein S27. (109 aa)
HASPINHistone H3 associated protein kinase. (738 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (811 aa)
Cacnb4SH3 domain-containing protein. (542 aa)
BRINP3BMP/retinoic acid inducible neural specific 3. (766 aa)
TOM1L2Target of myb1 like 2 membrane trafficking protein; Belongs to the TOM1 family. (528 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
FHL1Four and a half LIM domains 1. (323 aa)
ENSSTOP00000028143WD_REPEATS_REGION domain-containing protein. (275 aa)
ENSSTOP00000028075Uncharacterized protein. (77 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
LOC101966497Fork-head domain-containing protein. (414 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
ENSSTOP00000027930Uncharacterized protein. (173 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ENSSTOP00000027725Uncharacterized protein. (407 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
ENSSTOP00000027042Uncharacterized protein. (51 aa)
FOXN3Forkhead box N3. (482 aa)
MFSD11Major facilitator superfamily domain containing 11. (449 aa)
INIPINTS3 and NABP interacting protein. (104 aa)
LOC101962169Uncharacterized protein. (83 aa)
Zfyve19Uncharacterized protein. (280 aa)
Stk33Protein kinase domain-containing protein. (322 aa)
LOC101962934Anti_prolifrtn domain-containing protein. (137 aa)
ENSSTOP00000025631Uncharacterized protein. (117 aa)
ENSSTOP00000025460Uncharacterized protein. (136 aa)
FAM107AFamily with sequence similarity 107 member A. (144 aa)
ENSSTOP00000024694Uncharacterized protein. (158 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (882 aa)
AVENApoptosis and caspase activation inhibitor. (265 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
I3NHC9_ICTTR40S ribosomal protein S27. (84 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (821 aa)
MIIPMigration and invasion inhibitory protein. (415 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
Hmga2Uncharacterized protein. (109 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (383 aa)
FOXO4Forkhead box O4. (505 aa)
BRD7Bromodomain containing 7. (648 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
Bub3WD_REPEATS_REGION domain-containing protein. (354 aa)
CLSPNClaspin. (1320 aa)
CTDSP2CTD small phosphatase 2. (271 aa)
ANGEL2Angel homolog 2. (544 aa)
RGCCRegulator of cell cycle. (161 aa)
I3NB72_ICTTRTreslin_N domain-containing protein. (409 aa)
RBL1RB transcriptional corepressor like 1. (1038 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (477 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (538 aa)
NACC2NACC family member 2. (584 aa)
KANK2KN motif and ankyrin repeat domains 2. (843 aa)
CDC73Cell division cycle 73. (531 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
TREX1Three prime repair exonuclease 1. (304 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (291 aa)
HECAHdc homolog, cell cycle regulator. (464 aa)
FAM122AFamily with sequence similarity 122A. (283 aa)
I3N2F3_ICTTRUncharacterized protein. (220 aa)
FBXO7F-box protein 7. (440 aa)
I3N0J6_ICTTRRAP80_UIM domain-containing protein. (166 aa)
CDC14BUncharacterized protein. (450 aa)
SYF2SYF2 pre-mRNA splicing factor. (146 aa)
LOC101962206Uncharacterized protein. (302 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (435 aa)
ZFP36L2ZFP36 ring finger protein like 2. (489 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (281 aa)
IER3Immediate early response 3. (157 aa)
JADE1Jade family PHD finger 1. (834 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2651 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (561 aa)
BRSK2BR serine/threonine kinase 2. (701 aa)
CDK2AP2Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (127 aa)
TAOK3TAO kinase 3. (898 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
CHFRCheckpoint with forkhead and ring finger domains. (724 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TRIM35Tripartite motif containing 35. (493 aa)
FBXO5F-box protein 5. (450 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PRMT2Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (433 aa)
CTNNB1Catenin beta 1. (781 aa)
TRIP13Thyroid hormone receptor interactor 13. (349 aa)
NABP2Nucleic acid binding protein 2. (211 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (862 aa)
CEP192Centrosomal protein 192. (2228 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (634 aa)
TAOK2TAO kinase 2. (1240 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
RAD21RAD21 cohesin complex component. (631 aa)
TAOK1TAO kinase 1. (1001 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
TPRTranslocated promoter region, nuclear basket protein. (2435 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (518 aa)
FANCD2FA complementation group D2. (1276 aa)
PIDD1P53-induced death domain protein 1. (915 aa)
WACWW domain containing adaptor with coiled-coil. (646 aa)
MEIOCMeiosis specific with coiled-coil domain. (960 aa)
MrnipUncharacterized protein. (223 aa)
PMLPromyelocytic leukemia. (877 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
Nabp1Uncharacterized protein. (199 aa)
YTHDC2YTH domain containing 2. (1433 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Vps4aUncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BABAM2BRISC and BRCA1 A complex member 2. (406 aa)
SDE2SDE2 telomere maintenance homolog. (470 aa)
Klhl22Kelch like family member 22. (634 aa)
PLK1Serine/threonine-protein kinase PLK. (601 aa)
CRLF3Cytokine receptor like factor 3. (442 aa)
FBXO31F-box protein 31. (484 aa)
Tom1l1Uncharacterized protein. (282 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (403 aa)
BRINP2BMP/retinoic acid inducible neural specific 2. (782 aa)
CHEK2Checkpoint kinase 2. (545 aa)
GIGYF2GRB10 interacting GYF protein 2. (1288 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
Btg3Uncharacterized protein. (252 aa)
RFWD3Ring finger and WD repeat domain 3. (808 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (344 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
ZWILCHZwilch kinetochore protein. (563 aa)
Bub1bUncharacterized protein. (1026 aa)
BTG4BTG anti-proliferation factor 4. (230 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (297 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
ZW10Zw10 kinetochore protein. (779 aa)
MTBPMDM2 binding protein. (904 aa)
DONSONDownstream neighbor of SON. (557 aa)
NEK11NIMA related kinase 11. (642 aa)
Babam1BRISC and BRCA1 A complex member 1. (335 aa)
GPNMBGlycoprotein nmb. (556 aa)
CTDSP1CTD small phosphatase 1. (238 aa)
ZNF655Zinc finger protein 655. (544 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (409 aa)
E2F7E2F transcription factor 7. (900 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
DCUN1D3DCN1-like protein. (304 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
PLK3Serine/threonine-protein kinase PLK. (646 aa)
Gpr132G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (378 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (502 aa)
I3M7E8_ICTTRUncharacterized protein. (157 aa)
NLE1Notchless homolog 1. (485 aa)
ZNF830Zinc finger protein 830. (370 aa)
BRSK1BR serine/threonine kinase 1. (772 aa)
MYO16Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1612 aa)
BRINP1BMP/retinoic acid inducible neural specific 1. (761 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (448 aa)
BLMBLM RecQ like helicase. (1414 aa)
RAD17RAD17 checkpoint clamp loader component. (699 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
RPA2Replication protein A2. (271 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
C10orf90Chromosome 10 open reading frame 90. (790 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
Pkd2EF-hand domain-containing protein. (892 aa)
SCRIBScribble planar cell polarity protein. (1546 aa)
MUS81MUS81 structure-specific endonuclease subunit. (567 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
NME6NME/NM23 nucleoside diphosphate kinase 6; Belongs to the NDK family. (115 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (432 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (250 aa)
TRIM39Tripartite motif containing 39. (488 aa)
CTDSPLCTD small phosphatase like. (272 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
KNTC1Kinetochore associated 1. (2206 aa)
Prap1Uncharacterized protein. (145 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (307 aa)
RB1RB transcriptional corepressor 1. (957 aa)
Znf207Uncharacterized protein. (494 aa)
INTS3Integrator complex subunit 3. (1040 aa)
Brca1Uncharacterized protein. (353 aa)
CCND1Cyclin D1. (250 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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