STRINGSTRING
EPHB1 EPHB1 ITCH ITCH MDFIC MDFIC TAOK1 TAOK1 SH3RF1 SH3RF1 CARD9 CARD9 Dusp3 Dusp3 MYD88 MYD88 PYCARD PYCARD LTBR LTBR UNC5CL UNC5CL TNF TNF SFRP4 SFRP4 AXIN1 AXIN1 SFRP5 SFRP5 ULK4 ULK4 TRAF2 TRAF2 DUSP10 DUSP10 IGF1R IGF1R DIXDC1 DIXDC1 MAP4K2 MAP4K2 GRIK2 GRIK2 FKTN FKTN CYLD CYLD TNFSF11 TNFSF11 TIRAP TIRAP HIPK3 HIPK3 TPD52L1 TPD52L1 Mfhas1 Mfhas1 MAP3K5 MAP3K5 MMP8 MMP8 EDA2R EDA2R I3MA50_ICTTR I3MA50_ICTTR CD27 CD27 TRAF6 TRAF6 COPS5 COPS5 SLAMF1 SLAMF1 MAP3K1 MAP3K1 EGFR EGFR WNT16 WNT16 NCF1 NCF1 MAGI3 MAGI3 PER1 PER1 SERPINF2 SERPINF2 NOX1 NOX1 TRAF4 TRAF4 MBIP MBIP MAPK8IP3 MAPK8IP3 SH3RF3 SH3RF3 XIAP XIAP RB1CC1 RB1CC1 CCL19 CCL19 TNIK TNIK PAFAH1B1 PAFAH1B1 SFRP2 SFRP2 IL1B IL1B DUSP22 DUSP22 RIPK1 RIPK1 KLHL31 KLHL31 Cdc42 Cdc42 TRAF3 TRAF3 DUSP19 DUSP19 MAPKBP1 MAPKBP1 ZNF622 ZNF622 RAPGEF1 RAPGEF1 RASSF2 RASSF2 MAP3K7 MAP3K7 ENSSTOP00000031788 ENSSTOP00000031788 MECOM MECOM DAB2 DAB2 LOC101966144 LOC101966144 RASGRP1 RASGRP1 PJA2 PJA2 SH3RF2 SH3RF2 MAP2K7 MAP2K7 MAPK9 MAPK9 PTK2B PTK2B ZMYND11 ZMYND11 FGD4 FGD4 BIRC7 BIRC7 ENSSTOP00000029589 ENSSTOP00000029589 PDCD4 PDCD4 TNFRSF19 TNFRSF19 AKT1 AKT1 NCOR1 NCOR1 MEN1 MEN1 STK3 STK3 APP APP TRAF5 TRAF5 AGER AGER TRPV4 TRPV4 ENSSTOP00000024508 ENSSTOP00000024508 CRK CRK PRMT1 PRMT1 DACT1 DACT1 DUSP16 DUSP16 TLR3 TLR3 WNT7B WNT7B MAP3K11 MAP3K11 TRAF1 TRAF1 FGF19 FGF19 F2RL1 F2RL1 I3NAC7_ICTTR I3NAC7_ICTTR WNT5A WNT5A MDFI MDFI GPS2 GPS2 CRACR2A CRACR2A Fcgr2b Fcgr2b I3N4S4_ICTTR I3N4S4_ICTTR WNT7A WNT7A DAB2IP DAB2IP CCL21 CCL21 MAP2K4 MAP2K4 GADD45B GADD45B FLT4 FLT4 PHLPP1 PHLPP1 EDAR EDAR TLR4 TLR4 MAPK8IP1 MAPK8IP1 MTURN MTURN MAPK8IP2 MAPK8IP2 GADD45G GADD45G NOD2 NOD2 TAOK3 TAOK3 SFRP1 SFRP1 MAP4K4 MAP4K4 GSTP1 GSTP1 NOD1 NOD1 CCN2 CCN2 Naip Naip HDAC3 HDAC3 ANKRD6 ANKRD6 PLCB1 PLCB1 RIPK2 RIPK2 TAOK2 TAOK2 MINK1 MINK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHB1EPH receptor B1. (984 aa)
ITCHE3 ubiquitin-protein ligase. (855 aa)
MDFICMyoD family inhibitor domain containing. (246 aa)
TAOK1TAO kinase 1. (1001 aa)
SH3RF1SH3 domain containing ring finger 1. (895 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
Dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PYCARDPYD and CARD domain containing. (194 aa)
LTBRLymphotoxin beta receptor. (435 aa)
UNC5CLUnc-5 family C-terminal like. (518 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SFRP4Secreted frizzled related protein 4. (347 aa)
AXIN1Axin 1. (869 aa)
SFRP5Secreted frizzled related protein 5. (316 aa)
ULK4Unc-51 like kinase 4. (1279 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
DIXDC1DIX domain containing 1. (705 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (789 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
FKTNFukutin. (461 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
TIRAPTIR domain containing adaptor protein. (222 aa)
HIPK3Homeodomain interacting protein kinase 3. (1214 aa)
TPD52L1TPD52 like 1. (204 aa)
Mfhas1Roc domain-containing protein. (1054 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1307 aa)
MMP8Matrix metallopeptidase 8. (403 aa)
EDA2REctodysplasin A2 receptor. (297 aa)
I3MA50_ICTTRUncharacterized protein. (220 aa)
CD27CD27 molecule. (239 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
COPS5COP9 signalosome subunit 5. (334 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (335 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1437 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
NCF1Neutrophil cytosolic factor 1. (405 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1452 aa)
PER1Period circadian regulator 1. (1294 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (417 aa)
NOX1NADPH oxidase 1. (561 aa)
TRAF4TNF receptor-associated factor. (470 aa)
MBIPMAP3K12 binding inhibitory protein 1. (344 aa)
MAPK8IP3Mitogen-activated protein kinase 8 interacting protein 3. (1337 aa)
SH3RF3SH3 domain containing ring finger 3. (757 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
CCL19C-C motif chemokine. (135 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (411 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
KLHL31Kelch like family member 31. (634 aa)
Cdc42Uncharacterized protein. (191 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (221 aa)
MAPKBP1Mitogen-activated protein kinase binding protein 1. (1501 aa)
ZNF622Zinc finger protein 622. (477 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1261 aa)
RASSF2Ras association domain family member 2. (326 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSSTOP00000031788Aida_C2 domain-containing protein. (135 aa)
MECOMMDS1 and EVI1 complex locus. (1051 aa)
DAB2DAB adaptor protein 2. (767 aa)
LOC101966144Uncharacterized protein. (147 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
PJA2Praja ring finger ubiquitin ligase 2. (701 aa)
SH3RF2SH3 domain containing ring finger 2. (730 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
ZMYND11Zinc finger MYND-type containing 11. (602 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (939 aa)
BIRC7Baculoviral IAP repeat containing 7. (304 aa)
ENSSTOP00000029589TNF receptor-associated factor. (402 aa)
PDCD4Programmed cell death 4. (469 aa)
TNFRSF19TNF receptor superfamily member 19. (417 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NCOR1Nuclear receptor corepressor 1. (2529 aa)
MEN1Menin 1. (616 aa)
STK3Serine/threonine kinase 3. (491 aa)
APPAmyloid beta precursor protein. (739 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
AGERAdvanced glycosylation end-product specific receptor. (450 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
ENSSTOP00000024508Roc domain-containing protein. (944 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (821 aa)
DUSP16Dual specificity phosphatase 16. (660 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (848 aa)
TRAF1TNF receptor-associated factor. (415 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
I3NAC7_ICTTRProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (349 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
MDFIMyoD family inhibitor. (185 aa)
GPS2G protein pathway suppressor 2. (327 aa)
CRACR2ACalcium release activated channel regulator 2A. (730 aa)
Fcgr2bUncharacterized protein. (341 aa)
I3N4S4_ICTTRUncharacterized protein. (162 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
DAB2IPDAB2 interacting protein. (1148 aa)
CCL21C-C motif chemokine ligand 21. (133 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1516 aa)
EDAREctodysplasin A receptor. (448 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (697 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (106 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (820 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
TAOK3TAO kinase 3. (898 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1244 aa)
GSTP1Glutathione S-transferase pi 1. (210 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (951 aa)
CCN2Cellular communication network factor 2. (348 aa)
NaipNACHT domain-containing protein. (1405 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
ANKRD6Ankyrin repeat domain 6. (727 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
TAOK2TAO kinase 2. (1240 aa)
MINK1Misshapen like kinase 1. (1342 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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