(96 nodes) Positive regulation of JNK cascade network (Ictidomys tridecemlineatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	RASSF2	Ras association domain family member 2. (326 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	DAB2	DAB adaptor protein 2. (767 aa)
	LOC101966144	Uncharacterized protein. (147 aa)
	RASGRP1	RAS guanyl releasing protein 1. (797 aa)
	PJA2	Praja ring finger ubiquitin ligase 2. (701 aa)
	SH3RF2	SH3 domain containing ring finger 2. (730 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (469 aa)
	PTK2B	Protein tyrosine kinase 2 beta. (968 aa)
	FGD4	FYVE, RhoGEF and PH domain containing 4. (939 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (304 aa)
	ENSSTOP00000029589	TNF receptor-associated factor. (402 aa)
	TNFRSF19	TNF receptor superfamily member 19. (417 aa)
	STK3	Serine/threonine kinase 3. (491 aa)
	APP	Amyloid beta precursor protein. (739 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	AGER	Advanced glycosylation end-product specific receptor. (450 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
	ENSSTOP00000024508	Roc domain-containing protein. (944 aa)
	CRK	CRK proto-oncogene, adaptor protein. (305 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	MAP3K11	Mitogen-activated protein kinase kinase kinase. (848 aa)
	TRAF1	TNF receptor-associated factor. (415 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
	F2RL1	F2R like trypsin receptor 1. (397 aa)
	I3NAC7_ICTTR	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (349 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	CRACR2A	Calcium release activated channel regulator 2A. (730 aa)
	Fcgr2b	Uncharacterized protein. (341 aa)
	I3N4S4_ICTTR	Uncharacterized protein. (162 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
	DAB2IP	DAB2 interacting protein. (1148 aa)
	CCL21	C-C motif chemokine ligand 21. (133 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
	EDAR	Ectodysplasin A receptor. (448 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (697 aa)
	MTURN	Maturin, neural progenitor differentiation regulator homolog. (106 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1014 aa)
	TAOK3	TAO kinase 3. (898 aa)
	MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4. (1244 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (951 aa)
	CCN2	Cellular communication network factor 2. (348 aa)
	Naip	NACHT domain-containing protein. (1405 aa)
	ANKRD6	Ankyrin repeat domain 6. (727 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	TAOK2	TAO kinase 2. (1240 aa)
	MINK1	Misshapen like kinase 1. (1342 aa)
	TAOK1	TAO kinase 1. (1001 aa)
	SH3RF1	SH3 domain containing ring finger 1. (895 aa)
	CARD9	Caspase recruitment domain family member 9. (537 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	PYCARD	PYD and CARD domain containing. (194 aa)
	LTBR	Lymphotoxin beta receptor. (435 aa)
	UNC5CL	Unc-5 family C-terminal like. (518 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	AXIN1	Axin 1. (869 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	DIXDC1	DIX domain containing 1. (705 aa)
	MAP4K2	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (789 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
	TIRAP	TIR domain containing adaptor protein. (222 aa)
	TPD52L1	TPD52 like 1. (204 aa)
	Mfhas1	Roc domain-containing protein. (1054 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1307 aa)
	MMP8	Matrix metallopeptidase 8. (403 aa)
	EDA2R	Ectodysplasin A2 receptor. (297 aa)
	CD27	CD27 molecule. (239 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
	SLAMF1	Signaling lymphocytic activation molecule family member 1. (335 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1437 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	NCF1	Neutrophil cytosolic factor 1. (405 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (417 aa)
	NOX1	NADPH oxidase 1. (561 aa)
	TRAF4	TNF receptor-associated factor. (470 aa)
	MBIP	MAP3K12 binding inhibitory protein 1. (344 aa)
	MAPK8IP3	Mitogen-activated protein kinase 8 interacting protein 3. (1337 aa)
	SH3RF3	SH3 domain containing ring finger 3. (757 aa)
	XIAP	X-linked inhibitor of apoptosis. (497 aa)
	RB1CC1	RB1 inducible coiled-coil 1. (1593 aa)
	CCL19	C-C motif chemokine. (135 aa)
	TNIK	TRAF2 and NCK interacting kinase. (1360 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
	DUSP22	Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (665 aa)
	Cdc42	Uncharacterized protein. (191 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
	DUSP19	Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (221 aa)
	MAPKBP1	Mitogen-activated protein kinase binding protein 1. (1501 aa)
	ZNF622	Zinc finger protein 622. (477 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSSTOP00000025224	ENSSTOP00000026933	Advanced glycosylation end-product specific receptor.	Amyloid beta precursor protein.	0.722
AGER	IL1B	ENSSTOP00000025224	ENSSTOP00000002047	Advanced glycosylation end-product specific receptor.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.453
AGER	NOX1	ENSSTOP00000025224	ENSSTOP00000004599	Advanced glycosylation end-product specific receptor.	NADPH oxidase 1.	0.845
AGER	TLR4	ENSSTOP00000025224	ENSSTOP00000017653	Advanced glycosylation end-product specific receptor.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.474
ANKRD6	APP	ENSSTOP00000014499	ENSSTOP00000026933	Ankyrin repeat domain 6.	Amyloid beta precursor protein.	0.724
ANKRD6	AXIN1	ENSSTOP00000014499	ENSSTOP00000011023	Ankyrin repeat domain 6.	Axin 1.	0.703
ANKRD6	CRK	ENSSTOP00000014499	ENSSTOP00000024503	Ankyrin repeat domain 6.	CRK proto-oncogene, adaptor protein.	0.421
ANKRD6	Cdc42	ENSSTOP00000014499	ENSSTOP00000000717	Ankyrin repeat domain 6.	Uncharacterized protein.	0.499
ANKRD6	I3N4S4_ICTTR	ENSSTOP00000014499	ENSSTOP00000019370	Ankyrin repeat domain 6.	Uncharacterized protein.	0.499
ANKRD6	IL1B	ENSSTOP00000014499	ENSSTOP00000002047	Ankyrin repeat domain 6.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.646
ANKRD6	LOC101966144	ENSSTOP00000014499	ENSSTOP00000031379	Ankyrin repeat domain 6.	Uncharacterized protein.	0.499
ANKRD6	MYD88	ENSSTOP00000014499	ENSSTOP00000012227	Ankyrin repeat domain 6.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.620
ANKRD6	TLR4	ENSSTOP00000014499	ENSSTOP00000017653	Ankyrin repeat domain 6.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.673
ANKRD6	TNF	ENSSTOP00000014499	ENSSTOP00000011546	Ankyrin repeat domain 6.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.601
ANKRD6	TRAF6	ENSSTOP00000014499	ENSSTOP00000006521	Ankyrin repeat domain 6.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.542
APP	AGER	ENSSTOP00000026933	ENSSTOP00000025224	Amyloid beta precursor protein.	Advanced glycosylation end-product specific receptor.	0.722
APP	ANKRD6	ENSSTOP00000026933	ENSSTOP00000014499	Amyloid beta precursor protein.	Ankyrin repeat domain 6.	0.724
APP	DAB2	ENSSTOP00000026933	ENSSTOP00000031387	Amyloid beta precursor protein.	DAB adaptor protein 2.	0.423
APP	FLT4	ENSSTOP00000026933	ENSSTOP00000018301	Amyloid beta precursor protein.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.417
APP	IL1B	ENSSTOP00000026933	ENSSTOP00000002047	Amyloid beta precursor protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.448