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MAPKAPK2 MAPKAPK2 I3M7E8_ICTTR I3M7E8_ICTTR ATP13A2 ATP13A2 SYK SYK HIPK4 HIPK4 THY1 THY1 MELK MELK EPHA1 EPHA1 CLK4 CLK4 HCK HCK BTK BTK PRKCD PRKCD CAMK4 CAMK4 ATM ATM UHMK1 UHMK1 FGFR2 FGFR2 PRKD1 PRKD1 Sik1 Sik1 BRD4 BRD4 RB1CC1 RB1CC1 EPHA4 EPHA4 TRIM24 TRIM24 FLT3 FLT3 ALK ALK TNIK TNIK STK11 STK11 FLT1 FLT1 RIPK3 RIPK3 Map2k2 Map2k2 PRKACA PRKACA TSSK4 TSSK4 CSNK1G3 CSNK1G3 MAP4K1 MAP4K1 EIF2S1 EIF2S1 RIPK1 RIPK1 INSR INSR KIT KIT FER FER LRRK2 LRRK2 ATG101 ATG101 ACVR1B ACVR1B CAMK2B CAMK2B MAPK7 MAPK7 FGFR4 FGFR4 TRPM7 TRPM7 ERBB4 ERBB4 GRK5 GRK5 STK17A STK17A MAP3K12 MAP3K12 STK16 STK16 MAPK15 MAPK15 TRIM28 TRIM28 CSF1R CSF1R Prkx Prkx CSNK1G2 CSNK1G2 TAOK3 TAOK3 TXK TXK LOC101955809 LOC101955809 FGR FGR MOS MOS STK25 STK25 ATR ATR GRK1 GRK1 AATK AATK PEAK1 PEAK1 SRC SRC KDR KDR DYRK1A DYRK1A EIF2AK4 EIF2AK4 DAPK1 DAPK1 TYRO3 TYRO3 MINK1 MINK1 EPHB1 EPHB1 FES FES CDKL5 CDKL5 TAOK1 TAOK1 PIM2 PIM2 NEK2 NEK2 CLK3 CLK3 EIF2AK2 EIF2AK2 NEK6 NEK6 STK39 STK39 TGFBR1 TGFBR1 SLK SLK PAK1 PAK1 VRK2 VRK2 MKNK2 MKNK2 LCK LCK DDR2 DDR2 CHEK2 CHEK2 VRK1 VRK1 IGF1R IGF1R CAD CAD PDGFRA PDGFRA I3MGY8_ICTTR I3MGY8_ICTTR ULK1 ULK1 HTATIP2 HTATIP2 ZAP70 ZAP70 EIF2AK3 EIF2AK3 CLK1 CLK1 EIF2AK1 EIF2AK1 STK4 STK4 ERN1 ERN1 CLK2 CLK2 NTRK2 NTRK2 CAMK2A CAMK2A MAP3K3 MAP3K3 HSPA9 HSPA9 Csnk2a1 Csnk2a1 BCR BCR PAK2 PAK2 MYO3B MYO3B NTRK1 NTRK1 SRMS SRMS PTK6 PTK6 MYLK2 MYLK2 TNK1 TNK1 NLK NLK FYN FYN MAP3K1 MAP3K1 IRAK3 IRAK3 EGFR EGFR JAK2 JAK2 STK24 STK24 RIOK2 RIOK2 BMX BMX FGFR3 FGFR3 CSNK1G1 CSNK1G1 HK1 HK1 DAPK3 DAPK3 PRKD2 PRKD2 WNK1 WNK1 MTOR MTOR SIK2 SIK2 CDK5 CDK5 STK26 STK26 PTK2 PTK2 TEK TEK ENSSTOP00000030493 ENSSTOP00000030493 PTK2B PTK2B AAK1 AAK1 MAK MAK EEF2K EEF2K EPHB3 EPHB3 EPHA8 EPHA8 WNK3 WNK3 MAPKAPK3 MAPKAPK3 LYN LYN CAMKK2 CAMKK2 MAP3K13 MAP3K13 DYRK1B DYRK1B PHKA1 PHKA1 PIKFYVE PIKFYVE FGFR1 FGFR1 DDR1 DDR1 MUSK MUSK EPHB4 EPHB4 SMG1 SMG1 Stk33 Stk33 LMTK2 LMTK2 PRKCG PRKCG ATG13 ATG13 IRAK1 IRAK1 MYO3A MYO3A MAPKAPK5 MAPKAPK5 PINK1 PINK1 ULK2 ULK2 CAMK2G CAMK2G WNK2 WNK2 ENSSTOP00000024013 ENSSTOP00000024013 PDGFRB PDGFRB GSK3B GSK3B MAPK14 MAPK14 ROS1 ROS1 CAMK2D CAMK2D MAP3K11 MAP3K11 Ulk3 Ulk3 STK17B STK17B I3N9L4_ICTTR I3N9L4_ICTTR OXSR1 OXSR1 PIM1 PIM1 CSK CSK Grk7 Grk7 STK10 STK10 MET MET INSRR INSRR PIM3 PIM3 FLT4 FLT4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (358 aa)
I3M7E8_ICTTRUncharacterized protein. (157 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1165 aa)
SYKTyrosine-protein kinase. (626 aa)
HIPK4Homeodomain interacting protein kinase 4. (616 aa)
THY1Thy-1 cell surface antigen. (162 aa)
MELKNon-specific serine/threonine protein kinase. (641 aa)
EPHA1EPH receptor A1. (978 aa)
CLK4CDC like kinase 4; Belongs to the protein kinase superfamily. (481 aa)
HCKTyrosine-protein kinase. (502 aa)
BTKTyrosine-protein kinase. (659 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (843 aa)
Sik1Uncharacterized protein. (776 aa)
BRD4Bromodomain containing 4. (1397 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
EPHA4EPH receptor A4. (986 aa)
TRIM24Tripartite motif containing 24. (996 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (985 aa)
ALKTyrosine-protein kinase receptor. (1612 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (491 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
TSSK4Testis specific serine kinase 4. (292 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (455 aa)
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (821 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
LRRK2Leucine rich repeat kinase 2. (2520 aa)
ATG101Autophagy related 101. (218 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (812 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1727 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (572 aa)
STK17ASerine/threonine kinase 17a; Belongs to the protein kinase superfamily. (413 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
STK16Serine/threonine kinase 16. (305 aa)
MAPK15Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (554 aa)
TRIM28Tripartite motif containing 28. (835 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
PrkxUncharacterized protein. (330 aa)
CSNK1G2Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (433 aa)
TAOK3TAO kinase 3. (898 aa)
TXKTyrosine-protein kinase. (526 aa)
LOC101955809Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1335 aa)
FGRTyrosine-protein kinase. (527 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (349 aa)
STK25Serine/threonine kinase 25. (421 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (564 aa)
AATKApoptosis associated tyrosine kinase. (1273 aa)
PEAK1Pseudopodium enriched atypical kinase 1. (1673 aa)
SRCTyrosine-protein kinase. (541 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1631 aa)
DAPK1Death associated protein kinase 1. (1432 aa)
TYRO3TYRO3 protein tyrosine kinase. (890 aa)
MINK1Misshapen like kinase 1. (1342 aa)
EPHB1EPH receptor B1. (984 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
CDKL5Cyclin dependent kinase like 5. (960 aa)
TAOK1TAO kinase 1. (1001 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (370 aa)
NEK2NIMA related kinase 2. (445 aa)
CLK3CDC like kinase 3. (600 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (538 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (325 aa)
STK39Serine/threonine kinase 39. (479 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
SLKSTE20 like kinase. (1242 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
VRK2VRK serine/threonine kinase 2. (508 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (461 aa)
LCKTyrosine-protein kinase. (521 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
CHEK2Checkpoint kinase 2. (545 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (396 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
CADCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2225 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
I3MGY8_ICTTRAGC-kinase C-terminal domain-containing protein. (107 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1041 aa)
HTATIP2HIV-1 Tat interactive protein 2. (273 aa)
ZAP70Tyrosine-protein kinase. (608 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1005 aa)
CLK1CDC like kinase 1; Belongs to the protein kinase superfamily. (484 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (623 aa)
STK4Serine/threonine kinase 4. (488 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (972 aa)
CLK2CDC like kinase 2; Belongs to the protein kinase superfamily. (500 aa)
NTRK2Tyrosine-protein kinase receptor. (821 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
Csnk2a1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
BCRBCR activator of RhoGEF and GTPase. (1283 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1304 aa)
NTRK1Tyrosine-protein kinase receptor. (799 aa)
SRMSTyrosine-protein kinase. (534 aa)
PTK6Tyrosine-protein kinase. (450 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (662 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
FYNTyrosine-protein kinase. (537 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1437 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (607 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
STK24Serine/threonine kinase 24. (432 aa)
RIOK2RIO kinase 2. (550 aa)
BMXTyrosine-protein kinase. (655 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (459 aa)
HK1Hexokinase 1. (920 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
WNK1WNK lysine deficient protein kinase 1. (2635 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
SIK2Salt inducible kinase 2. (930 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
STK26Serine/threonine kinase 26. (416 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ENSSTOP00000030493Uncharacterized protein. (70 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
AAK1AP2 associated kinase 1. (982 aa)
MAKMale germ cell associated kinase. (606 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
EPHB3EPH receptor B3. (996 aa)
EPHA8EPH receptor A8. (1006 aa)
WNK3WNK lysine deficient protein kinase 3. (1745 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
LYNTyrosine-protein kinase. (512 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (587 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (673 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1241 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (1999 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (915 aa)
MUSKMuscle associated receptor tyrosine kinase. (884 aa)
EPHB4EPH receptor B4. (987 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3664 aa)
Stk33Protein kinase domain-containing protein. (322 aa)
LMTK2Lemur tyrosine kinase 2. (1485 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1595 aa)
MAPKAPK5MAPK activated protein kinase 5. (472 aa)
PINK1PTEN induced kinase 1. (574 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1058 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (512 aa)
WNK2WNK lysine deficient protein kinase 2. (2057 aa)
ENSSTOP00000024013Uncharacterized protein. (102 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ROS1Tyrosine-protein kinase receptor. (2333 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (514 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (848 aa)
Ulk3Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (461 aa)
STK17BSerine/threonine kinase 17b; Belongs to the protein kinase superfamily. (372 aa)
I3N9L4_ICTTRProtein kinase domain-containing protein. (388 aa)
OXSR1Oxidative stress responsive kinase 1. (527 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
CSKTyrosine-protein kinase. (450 aa)
Grk7Rhodopsin kinase GRK7; Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). (548 aa)
STK10Serine/threonine kinase 10. (968 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
INSRRTyrosine-protein kinase receptor. (1279 aa)
PIM3Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (297 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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