STRINGSTRING
ENSSTOP00000028075 ENSSTOP00000028075 LHX6 LHX6 BSPH1 BSPH1 ROPN1L ROPN1L AXL AXL RUNX2 RUNX2 ESR2 ESR2 EPHA8 EPHA8 PTK2B PTK2B ADGRB3 ADGRB3 IL21 IL21 SLC26A6 SLC26A6 C1QA C1QA ENSSTOP00000032442 ENSSTOP00000032442 DMC1 DMC1 BFSP1 BFSP1 I3N4N6_ICTTR I3N4N6_ICTTR FAM20C FAM20C PDGFB PDGFB WDR77 WDR77 PGR PGR TDRD15 TDRD15 CSPG4 CSPG4 PCSK4 PCSK4 TDRD5 TDRD5 TUSC2 TUSC2 Akr1b1 Akr1b1 BHLHA15 BHLHA15 PLD6 PLD6 CNTN2 CNTN2 BTK BTK Hif1a Hif1a SCARF1 SCARF1 RPS6KA2 RPS6KA2 SLC22A14 SLC22A14 I3M6A8_ICTTR I3M6A8_ICTTR MAEA MAEA I3M6L1_ICTTR I3M6L1_ICTTR IL15 IL15 ABHD2 ABHD2 GATA2 GATA2 TDRKH TDRKH RFX3 RFX3 FGG FGG ANKS1A ANKS1A EREG EREG EDN1 EDN1 TUT7 TUT7 I3LX54_ICTTR I3LX54_ICTTR TYMS TYMS RB1 RB1 GATA3 GATA3 RET RET PLA2G3 PLA2G3 PDE3A PDE3A REC8 REC8 PRKACA PRKACA KDM1A KDM1A NTN4 NTN4 CCL19 CCL19 NR4A2 NR4A2 PTH1R PTH1R TDRD1 TDRD1 PABPC1L PABPC1L MYOC MYOC B4GALT5 B4GALT5 CATSPER3 CATSPER3 Xbp1 Xbp1 Ropn1 Ropn1 RND1 RND1 Foxo3 Foxo3 GLDN GLDN PLA2G10 PLA2G10 SLC26A8 SLC26A8 TAL1 TAL1 SOX8 SOX8 GBA GBA SPINK1 SPINK1 TGFB1 TGFB1 L3MBTL3 L3MBTL3 HBZ HBZ RXFP2 RXFP2 B4GALT6 B4GALT6 SLC26A3 SLC26A3 HOXA5 HOXA5 LGI4 LGI4 SCLT1 SCLT1 EPAS1 EPAS1 GPAT4 GPAT4 PPARG PPARG TFCP2L1 TFCP2L1 ACTL6B ACTL6B EPO EPO MTHFSD MTHFSD BFSP2 BFSP2 HOXB13 HOXB13 REN REN GHRHR GHRHR FEM1B FEM1B TUT4 TUT4 I3MQ94_ICTTR I3MQ94_ICTTR TRIP13 TRIP13 CTNNB1 CTNNB1 KDR KDR Kcne1 Kcne1 FOXA1 FOXA1 FBXO5 FBXO5 WASHC1 WASHC1 Sptbn4 Sptbn4 IQCF5 IQCF5 IRX5 IRX5 CCR6 CCR6 FARP2 FARP2 EFCAB9 EFCAB9 PMP22 PMP22 Cabyr Cabyr TMEM79 TMEM79 FEV FEV SOX10 SOX10 I3MYT1_ICTTR I3MYT1_ICTTR KCNIP2 KCNIP2 H3-3A H3-3A Cebpa Cebpa RUNX1 RUNX1 SOX18 SOX18 IQCF1 IQCF1 Dazl Dazl HES1 HES1 I3N753_ICTTR I3N753_ICTTR SIX3 SIX3 G6PD G6PD I3N829_ICTTR I3N829_ICTTR CATSPER2 CATSPER2 ZBTB7A ZBTB7A CATSPER4 CATSPER4 NEUROG2 NEUROG2 TDRD6 TDRD6 EDNRA EDNRA IHH IHH ASCL1 ASCL1 HES5 HES5 ID2 ID2 VSX1 VSX1 TDRD7 TDRD7 Cdc25b Cdc25b SRRM4 SRRM4 GDF11 GDF11 ANGPTL8 ANGPTL8 RUNX3 RUNX3 PTBP3 PTBP3 KCNMA1 KCNMA1 CBFB CBFB NFASC NFASC BAP1 BAP1 ENSSTOP00000025799 ENSSTOP00000025799 WASHC5 WASHC5 MECP2 MECP2 APP APP LOC101963257 LOC101963257 FGFR1 FGFR1 ERCC2 ERCC2 KCNB1 KCNB1 POU2F2 POU2F2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSSTOP00000028075Uncharacterized protein. (77 aa)
LHX6LIM homeobox 6. (373 aa)
BSPH1Binder of sperm protein homolog 1. (91 aa)
ROPN1LRhophilin associated tail protein 1 like. (219 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (520 aa)
ESR2Estrogen receptor 2. (525 aa)
EPHA8EPH receptor A8. (1006 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
SLC26A6Solute carrier family 26 member 6. (740 aa)
C1QAComplement C1q A chain. (240 aa)
ENSSTOP00000032442ANK_REP_REGION domain-containing protein. (460 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
BFSP1Beaded filament structural protein 1; Belongs to the intermediate filament family. (665 aa)
I3N4N6_ICTTRRhodanese domain-containing protein. (465 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (580 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
WDR77WD repeat domain 77. (342 aa)
PGRProgesterone receptor. (932 aa)
TDRD15Tudor domain containing 15. (2089 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2322 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (645 aa)
TDRD5Tudor domain containing 5. (1037 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
Akr1b1Aldo_ket_red domain-containing protein. (316 aa)
BHLHA15Basic helix-loop-helix family member a15. (190 aa)
PLD6Phospholipase D family member 6. (222 aa)
CNTN2Contactin 2. (1045 aa)
BTKTyrosine-protein kinase. (659 aa)
Hif1aUncharacterized protein. (821 aa)
SCARF1Scavenger receptor class F member 1. (893 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
SLC22A14Solute carrier family 22 member 14. (603 aa)
I3M6A8_ICTTRUncharacterized protein. (968 aa)
MAEAMacrophage erythroblast attacher. (434 aa)
I3M6L1_ICTTRABC transmembrane type-1 domain-containing protein. (528 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (134 aa)
ABHD2Abhydrolase domain containing 2. (425 aa)
GATA2GATA binding protein 2. (481 aa)
TDRKHTudor and KH domain containing. (561 aa)
RFX3Regulatory factor X3. (749 aa)
FGGFibrinogen gamma chain. (445 aa)
ANKS1AAnkyrin repeat and sterile alpha motif domain containing 1A. (1129 aa)
EREGEpiregulin. (163 aa)
EDN1Endothelin 1. (202 aa)
TUT7Terminal uridylyl transferase 7. (1475 aa)
I3LX54_ICTTRUncharacterized protein. (327 aa)
TYMSUncharacterized protein. (218 aa)
RB1RB transcriptional corepressor 1. (957 aa)
GATA3GATA binding protein 3. (444 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1112 aa)
PLA2G3Phospholipase A2 group III. (626 aa)
PDE3APhosphodiesterase. (1145 aa)
REC8REC8 meiotic recombination protein. (594 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (755 aa)
NTN4Netrin 4. (627 aa)
CCL19C-C motif chemokine. (135 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
TDRD1Tudor domain containing 1. (1167 aa)
PABPC1LPolyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (614 aa)
MYOCMyocilin. (487 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (349 aa)
CATSPER3Cation channel sperm associated 3. (393 aa)
Xbp1BZIP domain-containing protein. (351 aa)
Ropn1Uncharacterized protein. (212 aa)
RND1Rho family GTPase 1. (232 aa)
Foxo3Forkhead box O3. (673 aa)
GLDNGliomedin. (551 aa)
PLA2G10Phospholipase A(2). (148 aa)
SLC26A8Solute carrier family 26 member 8. (1002 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
SOX8SRY-box transcription factor 8. (466 aa)
GBAGlucosylceramidase. (516 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (68 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
L3MBTL3L3MBTL histone methyl-lysine binding protein 3. (699 aa)
HBZHemoglobin subunit zeta; Belongs to the globin family. (142 aa)
RXFP2Relaxin family peptide receptor 2. (737 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (382 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (758 aa)
HOXA5Homeobox A5. (270 aa)
LGI4Leucine rich repeat LGI family member 4. (541 aa)
SCLT1Sodium channel and clathrin linker 1. (688 aa)
EPAS1Endothelial PAS domain protein 1. (867 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TFCP2L1Transcription factor CP2 like 1. (479 aa)
ACTL6BActin like 6B; Belongs to the actin family. (426 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
MTHFSDMethenyltetrahydrofolate synthetase domain containing. (369 aa)
BFSP2Beaded filament structural protein 2; Belongs to the intermediate filament family. (415 aa)
HOXB13Homeobox B13. (284 aa)
RENRenin; Belongs to the peptidase A1 family. (401 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
FEM1BFem-1 homolog B. (627 aa)
TUT4Terminal uridylyl transferase 4. (1661 aa)
I3MQ94_ICTTRUncharacterized protein. (1171 aa)
TRIP13Thyroid hormone receptor interactor 13. (349 aa)
CTNNB1Catenin beta 1. (781 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
Kcne1Uncharacterized protein. (129 aa)
FOXA1Forkhead box A1. (468 aa)
FBXO5F-box protein 5. (450 aa)
WASHC1WASH complex subunit 1. (471 aa)
Sptbn4Spectrin beta, non-erythrocytic 4. (2570 aa)
IQCF5IQ motif containing F5. (148 aa)
IRX5Iroquois homeobox 5. (424 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (362 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1063 aa)
EFCAB9EF-hand calcium binding domain 9. (180 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
CabyrRIIa domain-containing protein. (381 aa)
TMEM79Transmembrane protein 79. (393 aa)
FEVFEV transcription factor, ETS family member. (173 aa)
SOX10SRY-box transcription factor 10. (466 aa)
I3MYT1_ICTTRAldo_ket_red domain-containing protein. (263 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (270 aa)
H3-3AHistone H3; Belongs to the histone H3 family. (136 aa)
CebpaUncharacterized protein. (122 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (467 aa)
SOX18SRY-box transcription factor 18. (383 aa)
IQCF1IQ motif containing F1. (171 aa)
DazlRRM domain-containing protein. (295 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
I3N753_ICTTRUncharacterized protein. (95 aa)
SIX3SIX homeobox 3. (275 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
I3N829_ICTTRRNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (225 aa)
CATSPER2Cation channel sperm associated 2. (542 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (414 aa)
CATSPER4Cation channel sperm associated 4. (420 aa)
NEUROG2Neurogenin 2. (271 aa)
TDRD6Tudor domain containing 6. (2116 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
IHHIndian hedgehog signaling molecule. (379 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (234 aa)
HES5Hes family bHLH transcription factor 5. (141 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
VSX1Visual system homeobox 1. (365 aa)
TDRD7Tudor domain containing 7. (1119 aa)
Cdc25bRhodanese domain-containing protein. (572 aa)
SRRM4Serine/arginine repetitive matrix 4. (517 aa)
GDF11Growth differentiation factor 11. (387 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
RUNX3RUNX family transcription factor 3. (419 aa)
PTBP3Polypyrimidine tract binding protein 3. (552 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1219 aa)
CBFBCore-binding factor subunit beta. (182 aa)
NFASCNeurofascin. (1239 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
ENSSTOP00000025799LAM_G_DOMAIN domain-containing protein. (176 aa)
WASHC5WASH complex subunit 5. (1189 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
APPAmyloid beta precursor protein. (739 aa)
LOC101963257Histone H3; Belongs to the histone H3 family. (136 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (859 aa)
POU2F2POU domain protein. (590 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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