(19 nodes) Sympathetic nervous system development network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRP2	Neuropilin; Belongs to the neuropilin family. (926 aa)
	GATA3	GATA binding protein 3. (444 aa)
	NTRK1	Tyrosine-protein kinase receptor. (799 aa)
	GFRA3	GDNF family receptor alpha 3. (394 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	PLXNA4	Plexin A4. (1893 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (785 aa)
	PHOX2A	Paired like homeobox 2A. (280 aa)
	TFAP2B	Transcription factor AP-2 beta. (460 aa)
	GDNF	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (212 aa)
	PHOX2B	Paired like homeobox 2B. (252 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (234 aa)
	TFAP2A	Transcription factor AP-2 alpha. (477 aa)
	NF1	Neurofibromin 1. (2473 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	GATA3	ENSSTOP00000021479	ENSSTOP00000000959	Achaete-scute family bHLH transcription factor 1.	GATA binding protein 3.	0.460
CTNNB1	FZD3	ENSSTOP00000014441	ENSSTOP00000009924	Catenin beta 1.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.629
CTNNB1	NTRK1	ENSSTOP00000014441	ENSSTOP00000007027	Catenin beta 1.	Tyrosine-protein kinase receptor.	0.534
FZD3	CTNNB1	ENSSTOP00000009924	ENSSTOP00000014441	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Catenin beta 1.	0.629
FZD3	NTRK1	ENSSTOP00000009924	ENSSTOP00000007027	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Tyrosine-protein kinase receptor.	0.496
GATA3	ASCL1	ENSSTOP00000000959	ENSSTOP00000021479	GATA binding protein 3.	Achaete-scute family bHLH transcription factor 1.	0.460
GATA3	HAND2	ENSSTOP00000000959	ENSSTOP00000020619	GATA binding protein 3.	Heart and neural crest derivatives expressed 2.	0.658
GATA3	PHOX2B	ENSSTOP00000000959	ENSSTOP00000019806	GATA binding protein 3.	Paired like homeobox 2B.	0.467
GDNF	GFRA3	ENSSTOP00000019471	ENSSTOP00000007756	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake.	GDNF family receptor alpha 3.	0.957
GDNF	NTRK1	ENSSTOP00000019471	ENSSTOP00000007027	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake.	Tyrosine-protein kinase receptor.	0.636
GFRA3	GDNF	ENSSTOP00000007756	ENSSTOP00000019471	GDNF family receptor alpha 3.	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake.	0.957
HAND2	GATA3	ENSSTOP00000020619	ENSSTOP00000000959	Heart and neural crest derivatives expressed 2.	GATA binding protein 3.	0.658
HAND2	PHOX2A	ENSSTOP00000020619	ENSSTOP00000015138	Heart and neural crest derivatives expressed 2.	Paired like homeobox 2A.	0.514
HAND2	PHOX2B	ENSSTOP00000020619	ENSSTOP00000019806	Heart and neural crest derivatives expressed 2.	Paired like homeobox 2B.	0.588
NRP1	NRP2	ENSSTOP00000012083	ENSSTOP00000028328	Neuropilin; Belongs to the neuropilin family.	Neuropilin; Belongs to the neuropilin family.	0.532
NRP1	NTRK1	ENSSTOP00000012083	ENSSTOP00000007027	Neuropilin; Belongs to the neuropilin family.	Tyrosine-protein kinase receptor.	0.495
NRP1	PLXNA4	ENSSTOP00000012083	ENSSTOP00000010196	Neuropilin; Belongs to the neuropilin family.	Plexin A4.	0.993
NRP1	SEMA3F	ENSSTOP00000012083	ENSSTOP00000014488	Neuropilin; Belongs to the neuropilin family.	Semaphorin 3F; Belongs to the semaphorin family.	0.948
NRP2	NRP1	ENSSTOP00000028328	ENSSTOP00000012083	Neuropilin; Belongs to the neuropilin family.	Neuropilin; Belongs to the neuropilin family.	0.532
NRP2	PLXNA4	ENSSTOP00000028328	ENSSTOP00000010196	Neuropilin; Belongs to the neuropilin family.	Plexin A4.	0.666