STRINGSTRING
IGF1R IGF1R PDGFRA PDGFRA I3MGY8_ICTTR I3MGY8_ICTTR RBM4B RBM4B PPARA PPARA CYP7B1 CYP7B1 MAT2A MAT2A FSHR FSHR PRMT5 PRMT5 Prokr1 Prokr1 PRKAA2 PRKAA2 Plekha1 Plekha1 CARTPT CARTPT CDK5R1 CDK5R1 HAS1 HAS1 PPP1CC PPP1CC NPAS2 NPAS2 NTRK2 NTRK2 ADCY1 ADCY1 Csnk2a1 Csnk2a1 GABRB1 GABRB1 PER2 PER2 DPYD DPYD MTA1 MTA1 NTRK1 NTRK1 NGFR NGFR ID1 ID1 DDB1 DDB1 RACK1 RACK1 FBXW9 FBXW9 HCRTR2 HCRTR2 EGFR EGFR STAT5A STAT5A STAT5B STAT5B NDUFA9 NDUFA9 NR1D1 NR1D1 KCNH7 KCNH7 MTOR MTOR Nfya Nfya ROCK2 ROCK2 SLIT2 SLIT2 JUN JUN Foxo3 Foxo3 MTNR1A MTNR1A TH TH Pcna Pcna I3NDF6_ICTTR I3NDF6_ICTTR I3NE76_ICTTR I3NE76_ICTTR Lhcgr Lhcgr KDM8 KDM8 ZFHX3 ZFHX3 GSK3B GSK3B GDF10 GDF10 GRIN2A GRIN2A ATF4 ATF4 GPR157 GPR157 DBP DBP PRKAA1 PRKAA1 ARRB2 ARRB2 PAM PAM ARRB1 ARRB1 ENSSTOP00000024247 ENSSTOP00000024247 HTR7 HTR7 NCOR2 NCOR2 KCND2 KCND2 KCNMA1 KCNMA1 GAS2 GAS2 NUDT12 NUDT12 GRIN1 GRIN1 ATF5 ATF5 PRKCG PRKCG SIRT6 SIRT6 CRY1 CRY1 ENSSTOP00000026011 ENSSTOP00000026011 ATG7 ATG7 IMPDH2 IMPDH2 PPP1CA PPP1CA PPARGC1A PPARGC1A ENSSTOP00000026381 ENSSTOP00000026381 NMS NMS RELB RELB ENSSTOP00000026639 ENSSTOP00000026639 RORB RORB CCDC90B CCDC90B SIAH2 SIAH2 GABRB3 GABRB3 PROKR2 PROKR2 HNF4A HNF4A PROX1 PROX1 ASS1 ASS1 KISS1 KISS1 CDK1 CDK1 ENSSTOP00000027865 ENSSTOP00000027865 ENSSTOP00000027992 ENSSTOP00000027992 NLGN1 NLGN1 CRTC1 CRTC1 ENSSTOP00000028212 ENSSTOP00000028212 NCOR1 NCOR1 LGR4 LGR4 SUV39H2 SUV39H2 NTRK3 NTRK3 AXL AXL SREBF1 SREBF1 RAI1 RAI1 EZH2 EZH2 ESR2 ESR2 IGF1 IGF1 MYCBP2 MYCBP2 Inhba Inhba PSPC1 PSPC1 ENSSTOP00000030497 ENSSTOP00000030497 MAPK9 MAPK9 NOS3 NOS3 USP7 USP7 ZPBP2 ZPBP2 PLA2G4A PLA2G4A CDK5 CDK5 NR5A1 NR5A1 EREG EREG FSHB FSHB THRAP3 THRAP3 EP300 EP300 BHLHE40 BHLHE40 TYMS TYMS GRIN2B GRIN2B KDM5A KDM5A PROK2 PROK2 ARNTL2 ARNTL2 MSTN MSTN ENOX2 ENOX2 CYP1B1 CYP1B1 RPE65 RPE65 CSNK1D CSNK1D MAPK10 MAPK10 METTL3 METTL3 ENPP2 ENPP2 PAX4 PAX4 SGPL1 SGPL1 Nr1d2 Nr1d2 GRIN3A GRIN3A TPH2 TPH2 AHCY AHCY Ahr Ahr HOMER1 HOMER1 OPN4 OPN4 KDM2A KDM2A AFP AFP TPH1 TPH1 DRD2 DRD2 NAGLU NAGLU Sik1 Sik1 GPR149 GPR149 MAGED1 MAGED1 HS3ST2 HS3ST2 TOP2A TOP2A CREBBP CREBBP CASP2 CASP2 LOC101967743 LOC101967743 PER1 PER1 CREM CREM USP2 USP2 MMP19 MMP19 Hnrnpu Hnrnpu PROK1 PROK1 HNRNPL HNRNPL BTBD9 BTBD9 SP1 SP1 C3orf70 C3orf70 SCAPER SCAPER TOP1 TOP1 ZNF830 ZNF830 MAPK8 MAPK8 DDX5 DDX5 HNF1B HNF1B RORA RORA Hdac1 Hdac1 OGT OGT DNM1L DNM1L NAMPT NAMPT CRY2 CRY2 CCKBR CCKBR PPARG PPARG HDAC2 HDAC2 PRF1 PRF1 AANAT AANAT PML PML SLIT3 SLIT3 HNRNPD HNRNPD Sfpq Sfpq PER3 PER3 TIMELESS TIMELESS NOCT NOCT EDN2 EDN2 MYBBP1A MYBBP1A BMPR1B BMPR1B SUV39H1 SUV39H1 TYRO3 TYRO3 GPR176 GPR176 NLGN3 NLGN3 NONO NONO ADIPOQ ADIPOQ CAVIN3 CAVIN3 DYRK1A DYRK1A CLOCK CLOCK HDAC3 HDAC3 DHX9 DHX9 TNFAIP6 TNFAIP6 AGRP AGRP CREB1 CREB1 MC3R MC3R LEP LEP Ciart Ciart SIRT1 SIRT1 FZD4 FZD4 AMH AMH PTX3 PTX3 KLF10 KLF10 PTEN PTEN I3MU87_ICTTR I3MU87_ICTTR MDK MDK NR0B2 NR0B2 GFPT1 GFPT1 ARNTL ARNTL HES7 HES7 DRD3 DRD3 HLF HLF ID3 ID3 EGR1 EGR1 NHLH2 NHLH2 MMP2 MMP2 AGT AGT FBXW7 FBXW7 DRD4 DRD4 NOS2 NOS2 TRPM2 TRPM2 PPP1CB PPP1CB I3MZU0_ICTTR I3MZU0_ICTTR ADNP ADNP OXTR OXTR ATOH7 ATOH7 TEF TEF TNFRSF11A TNFRSF11A KIAA2013 KIAA2013 RORC RORC PGR PGR I3N433_ICTTR I3N433_ICTTR TP53 TP53 NPY5R NPY5R SETX SETX NRIP1 NRIP1 Kmt2a Kmt2a SIX3 SIX3 ENOX1 ENOX1 MAGEL2 MAGEL2 RBM4 RBM4 ANXA1 ANXA1 NFIL3 NFIL3 NCOA2 NCOA2 SERPINF1 SERPINF1 F7 F7 CRX CRX PTN PTN ADAMTS1 ADAMTS1 ID2 ID2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
protein homology
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IGF1RTyrosine-protein kinase receptor. (1368 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
I3MGY8_ICTTRAGC-kinase C-terminal domain-containing protein. (107 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (497 aa)
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (671 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
Prokr1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (393 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
Plekha1Uncharacterized protein. (343 aa)
CARTPTCART prepropeptide. (129 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
HAS1Hyaluronan synthase 1. (539 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
NPAS2Neuronal PAS domain protein 2. (814 aa)
NTRK2Tyrosine-protein kinase receptor. (821 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
Csnk2a1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
PER2Period circadian regulator 2. (1297 aa)
DPYDDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (971 aa)
MTA1Metastasis associated 1. (689 aa)
NTRK1Tyrosine-protein kinase receptor. (799 aa)
NGFRNerve growth factor receptor. (428 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (151 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
FBXW9F-box and WD repeat domain containing 9. (462 aa)
HCRTR2Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (461 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
STAT5ASignal transducer and activator of transcription. (773 aa)
STAT5BSignal transducer and activator of transcription. (765 aa)
NDUFA9NADH:ubiquinone oxidoreductase subunit A9. (314 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (611 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7. (1195 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
NfyaUncharacterized protein. (347 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
SLIT2Slit guidance ligand 2. (1559 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Foxo3Forkhead box O3. (673 aa)
MTNR1AMelatonin receptor 1A; Belongs to the G-protein coupled receptor 1 family. (353 aa)
THTyrosine hydroxylase. (497 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
I3NDF6_ICTTRUncharacterized protein. (404 aa)
I3NE76_ICTTRUncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (435 aa)
LhcgrLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
KDM8Lysine demethylase 8. (419 aa)
ZFHX3Zinc finger homeobox 3. (3696 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1423 aa)
ATF4Activating transcription factor 4. (352 aa)
GPR157G protein-coupled receptor 157. (335 aa)
DBPD-box binding PAR bZIP transcription factor. (326 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
ARRB2Arrestin beta 2. (409 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (979 aa)
ARRB1Arrestin beta 1. (418 aa)
ENSSTOP00000024247Uncharacterized protein. (327 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (465 aa)
NCOR2Nuclear receptor corepressor 2. (2447 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1219 aa)
GAS2Growth arrest specific 2. (314 aa)
NUDT12Nudix hydrolase 12. (462 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
ATF5Activating transcription factor 5. (206 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SIRT6Sirtuin 6. (351 aa)
CRY1Cryptochrome circadian regulator 1. (609 aa)
ENSSTOP00000026011BHLH domain-containing protein. (102 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (726 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (538 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
ENSSTOP00000026381Uncharacterized protein. (87 aa)
NMSNeuromedin S. (153 aa)
RELBRELB proto-oncogene, NF-kB subunit. (567 aa)
ENSSTOP00000026639Hist_deacetyl domain-containing protein. (323 aa)
RORBRAR related orphan receptor B. (468 aa)
CCDC90BCoiled-coil domain containing 90B. (256 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (318 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (493 aa)
PROKR2Prokineticin receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PROX1Prospero homeobox 1. (737 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
KISS1KiSS-1 metastasis suppressor. (135 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ENSSTOP00000027865Uncharacterized protein. (255 aa)
ENSSTOP00000027992Sulfotransferase; Belongs to the sulfotransferase 1 family. (209 aa)
NLGN1Neuroligin 1. (843 aa)
CRTC1CREB regulated transcription coactivator 1. (654 aa)
ENSSTOP00000028212NR LBD domain-containing protein. (87 aa)
NCOR1Nuclear receptor corepressor 1. (2529 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (927 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (458 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1152 aa)
RAI1Retinoic acid induced 1. (1928 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
ESR2Estrogen receptor 2. (525 aa)
IGF1Insulin like growth factor 1. (166 aa)
MYCBP2MYC binding protein 2. (4754 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
PSPC1Paraspeckle component 1. (523 aa)
ENSSTOP00000030497SER_THR_PHOSPHATASE domain-containing protein. (298 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1085 aa)
ZPBP2Zona pellucida binding protein 2. (337 aa)
PLA2G4APhospholipase A2. (750 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
EREGEpiregulin. (163 aa)
FSHBFollicle stimulating hormone subunit beta. (130 aa)
THRAP3Thyroid hormone receptor associated protein 3. (955 aa)
EP300E1A binding protein p300. (2423 aa)
BHLHE40Basic helix-loop-helix family member e40. (411 aa)
TYMSUncharacterized protein. (218 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
KDM5ALysine demethylase 5A. (1690 aa)
PROK2Prokineticin 2. (103 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (561 aa)
MSTNMyostatin. (376 aa)
ENOX2Ecto-NOX disulfide-thiol exchanger 2. (593 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
CSNK1DCasein kinase 1 delta. (389 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (915 aa)
PAX4Paired box 4. (350 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
Nr1d2Uncharacterized protein. (573 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
TPH2Tryptophan hydroxylase 2. (491 aa)
AHCYAdenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (432 aa)
AhrUncharacterized protein. (848 aa)
HOMER1Homer scaffold protein 1. (363 aa)
OPN4Opsin 4. (520 aa)
KDM2ALysine demethylase 2A. (1162 aa)
AFPAlpha fetoprotein. (608 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (743 aa)
Sik1Uncharacterized protein. (776 aa)
GPR149G protein-coupled receptor 149. (731 aa)
MAGED1MAGE family member D1. (783 aa)
HS3ST2Sulfotransferase; Belongs to the sulfotransferase 1 family. (367 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1534 aa)
CREBBPCREB binding protein. (2410 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (448 aa)
LOC101967743Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
PER1Period circadian regulator 1. (1294 aa)
CREMcAMP responsive element modulator. (360 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (612 aa)
MMP19Matrix metallopeptidase 19. (539 aa)
HnrnpuB30.2/SPRY domain-containing protein. (411 aa)
PROK1Prokineticin 1. (96 aa)
HNRNPLHeterogeneous nuclear ribonucleoprotein L. (588 aa)
BTBD9BTB domain containing 9. (612 aa)
SP1Sp1 transcription factor. (788 aa)
C3orf70Chromosome 3 open reading frame 70. (250 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1398 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
ZNF830Zinc finger protein 830. (370 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
HNF1BHNF1 homeobox B. (558 aa)
RORARAR related orphan receptor A. (521 aa)
Hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (399 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (469 aa)
CRY2Cryptochrome circadian regulator 2. (593 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (454 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PRF1Perforin 1. (556 aa)
AANATAralkylamine N-acetyltransferase. (212 aa)
PMLPromyelocytic leukemia. (877 aa)
SLIT3Slit guidance ligand 3. (1385 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (356 aa)
SfpqRRM domain-containing protein. (351 aa)
PER3Period circadian regulator 3. (1062 aa)
TIMELESSTimeless circadian regulator. (1147 aa)
NOCTNocturnin. (367 aa)
EDN2Endothelin 2. (148 aa)
MYBBP1AMYB binding protein 1a. (1318 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
TYRO3TYRO3 protein tyrosine kinase. (890 aa)
GPR176G protein-coupled receptor 176. (513 aa)
NLGN3Neuroligin 3. (848 aa)
NONONon-POU domain containing octamer binding. (470 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
CAVIN3Caveolae associated protein 3. (251 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
CLOCKClock circadian regulator. (864 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
DHX9DExH-box helicase 9. (1328 aa)
TNFAIP6TNF alpha induced protein 6. (276 aa)
AGRPAgouti related neuropeptide. (132 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MC3RMelanocortin 3 receptor. (322 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CiartUncharacterized protein. (123 aa)
SIRT1Sirtuin 1. (602 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
AMHAnti-Mullerian hormone. (545 aa)
PTX3Pentraxin 3. (367 aa)
KLF10Kruppel like factor 10. (480 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
I3MU87_ICTTRProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (250 aa)
MDKMidkine. (143 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (260 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (633 aa)
HES7Hes family bHLH transcription factor 7. (225 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (445 aa)
HLFHLF transcription factor, PAR bZIP family member. (295 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
FBXW7F-box and WD repeat domain containing 7. (713 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (374 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1070 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1499 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
I3MZU0_ICTTRLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (138 aa)
ADNPActivity dependent neuroprotector homeobox. (1103 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
ATOH7Atonal bHLH transcription factor 7. (152 aa)
TEFTEF transcription factor, PAR bZIP family member. (301 aa)
TNFRSF11ATNF receptor superfamily member 11a. (625 aa)
KIAA2013KIAA2013. (557 aa)
RORCRAR related orphan receptor C. (518 aa)
PGRProgesterone receptor. (932 aa)
I3N433_ICTTRBHLH domain-containing protein. (131 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
NPY5RNeuropeptide Y receptor Y5. (446 aa)
SETXSenataxin. (2708 aa)
NRIP1Nuclear receptor interacting protein 1. (1157 aa)
Kmt2aHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3871 aa)
SIX3SIX homeobox 3. (275 aa)
ENOX1Ecto-NOX disulfide-thiol exchanger 1. (643 aa)
MAGEL2MAGE family member L2. (1204 aa)
RBM4RNA binding motif protein 4. (365 aa)
ANXA1Annexin. (346 aa)
NFIL3Nuclear factor, interleukin 3 regulated. (463 aa)
NCOA2Nuclear receptor coactivator. (1465 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (417 aa)
F7Coagulation factor VII; Belongs to the peptidase S1 family. (375 aa)
CRXCone-rod homeobox. (299 aa)
PTNPleiotrophin. (142 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (965 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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