STRINGSTRING
SHOX2 SHOX2 TCF7L2 TCF7L2 Gata4 Gata4 TCF21 TCF21 GLI3 GLI3 Pitx2 Pitx2 ID2 ID2 IHH IHH SIX2 SIX2 OVOL2 OVOL2 FGF10 FGF10 TCF7 TCF7 SHH SHH NIPBL NIPBL HNF1B HNF1B PDGFRA PDGFRA RBPMS2 RBPMS2 HLX HLX FGFR2 FGFR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHOX2Short stature homeobox 2. (319 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
Gata4GATA-type domain-containing protein. (212 aa)
TCF21Transcription factor 21. (179 aa)
GLI3GLI family zinc finger 3. (1582 aa)
Pitx2Homeobox protein. (325 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
IHHIndian hedgehog signaling molecule. (379 aa)
SIX2SIX homeobox 2. (296 aa)
OVOL2Ovo like zinc finger 2. (276 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
TCF7Transcription factor 7. (302 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
NIPBLNipped-B protein. (2803 aa)
HNF1BHNF1 homeobox B. (558 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (206 aa)
HLXH2.0 like homeobox. (490 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.