(27 nodes) Smooth muscle tissue development network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
	Foxp1	Fork-head domain-containing protein. (674 aa)
	IHH	Indian hedgehog signaling molecule. (379 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	TIPARP	TCDD inducible poly(ADP-ribose) polymerase. (681 aa)
	SIX1	SIX homeobox 1. (284 aa)
	SHH	Sonic hedgehog signaling molecule. (370 aa)
	TFAP2B	Transcription factor AP-2 beta. (460 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	SRF	Serum response factor. (505 aa)
	Zfand5	Uncharacterized protein. (172 aa)
	FOXP2	Forkhead box P2. (737 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	MYLK	Myosin light chain kinase. (1897 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	Ahr	Uncharacterized protein. (848 aa)
	Pkd2	EF-hand domain-containing protein. (892 aa)
	LOC101961235	Uncharacterized protein. (214 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1066 aa)
	ENG	Endoglin. (463 aa)
	STRA6	Stimulated by retinoic acid 6. (662 aa)
	PTCH1	Patched 1. (1450 aa)
	COL3A1	Collagen type III alpha 1 chain. (1462 aa)
	TSHZ3	Teashirt zinc finger homeobox 3. (1089 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	NF1	Neurofibromin 1. (2473 aa)
	EFEMP2	EGF containing fibulin extracellular matrix protein 2. (443 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	IHH	ENSSTOP00000001023	ENSSTOP00000021364	Bone morphogenetic protein 4.	Indian hedgehog signaling molecule.	0.426
BMP4	PTCH1	ENSSTOP00000001023	ENSSTOP00000031262	Bone morphogenetic protein 4.	Patched 1.	0.537
BMP4	SHH	ENSSTOP00000001023	ENSSTOP00000015201	Bone morphogenetic protein 4.	Sonic hedgehog signaling molecule.	0.691
BMP4	SMO	ENSSTOP00000001023	ENSSTOP00000010265	Bone morphogenetic protein 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.408
COL3A1	EFEMP2	ENSSTOP00000031169	ENSSTOP00000025000	Collagen type III alpha 1 chain.	EGF containing fibulin extracellular matrix protein 2.	0.435
COL3A1	ITGA8	ENSSTOP00000031169	ENSSTOP00000006774	Collagen type III alpha 1 chain.	Integrin subunit alpha 8; Belongs to the integrin alpha chain family.	0.523
EFEMP2	COL3A1	ENSSTOP00000025000	ENSSTOP00000031169	EGF containing fibulin extracellular matrix protein 2.	Collagen type III alpha 1 chain.	0.435
FOXP2	Foxp1	ENSSTOP00000008036	ENSSTOP00000022242	Forkhead box P2.	Fork-head domain-containing protein.	0.756
Foxp1	FOXP2	ENSSTOP00000022242	ENSSTOP00000008036	Fork-head domain-containing protein.	Forkhead box P2.	0.756
Foxp1	PROX1	ENSSTOP00000022242	ENSSTOP00000027381	Fork-head domain-containing protein.	Prospero homeobox 1.	0.408
IHH	BMP4	ENSSTOP00000021364	ENSSTOP00000001023	Indian hedgehog signaling molecule.	Bone morphogenetic protein 4.	0.426
IHH	PTCH1	ENSSTOP00000021364	ENSSTOP00000031262	Indian hedgehog signaling molecule.	Patched 1.	0.990
IHH	SHH	ENSSTOP00000021364	ENSSTOP00000015201	Indian hedgehog signaling molecule.	Sonic hedgehog signaling molecule.	0.860
IHH	SMO	ENSSTOP00000021364	ENSSTOP00000010265	Indian hedgehog signaling molecule.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.863
IHH	SOX9	ENSSTOP00000021364	ENSSTOP00000021123	Indian hedgehog signaling molecule.	SRY-box transcription factor 9.	0.544
ITGA8	COL3A1	ENSSTOP00000006774	ENSSTOP00000031169	Integrin subunit alpha 8; Belongs to the integrin alpha chain family.	Collagen type III alpha 1 chain.	0.523
LOC101961235	TIPARP	ENSSTOP00000006526	ENSSTOP00000018666	Uncharacterized protein.	TCDD inducible poly(ADP-ribose) polymerase.	0.410
PROX1	Foxp1	ENSSTOP00000027381	ENSSTOP00000022242	Prospero homeobox 1.	Fork-head domain-containing protein.	0.408
PTCH1	BMP4	ENSSTOP00000031262	ENSSTOP00000001023	Patched 1.	Bone morphogenetic protein 4.	0.537
PTCH1	IHH	ENSSTOP00000031262	ENSSTOP00000021364	Patched 1.	Indian hedgehog signaling molecule.	0.990