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FOXA2 FOXA2 NRARP NRARP SPRY1 SPRY1 PGF PGF WNT5A WNT5A MMP14 MMP14 PHB2 PHB2 SOX9 SOX9 EDNRA EDNRA BTRC BTRC IHH IHH RSPO2 RSPO2 FGF1 FGF1 PLXND1 PLXND1 DLG5 DLG5 GREB1L GREB1L GDF2 GDF2 Pitx2 Pitx2 LOC101964462 LOC101964462 SALL1 SALL1 GLI3 GLI3 TCF21 TCF21 Hmga2 Hmga2 DICER1 DICER1 DSPP DSPP DCHS1 DCHS1 TGFBR2 TGFBR2 ETV4 ETV4 TBX3 TBX3 NKX3-1 NKX3-1 ENSSTOP00000025781 ENSSTOP00000025781 TBX20 TBX20 PBX1 PBX1 PPP1CA PPP1CA PAX8 PAX8 DDR1 DDR1 FGF8 FGF8 NPNT NPNT DAG1 DAG1 IGF1 IGF1 NCOA3 NCOA3 PTCH1 PTCH1 VDR VDR TFAP2C TFAP2C LEF1 LEF1 SLIT2 SLIT2 TMEM67 TMEM67 PLEKHH1 PLEKHH1 KDM5B KDM5B MSX2 MSX2 EDN1 EDN1 WNT4 WNT4 BMP4 BMP4 GNA13 GNA13 Clic4 Clic4 SFRP2 SFRP2 LOC101973790 LOC101973790 VANGL2 VANGL2 SEMA5A SEMA5A NFATC4 NFATC4 DLL4 DLL4 EPHA2 EPHA2 Ahr Ahr SLC12A2 SLC12A2 WNT1 WNT1 Pkd2 Pkd2 FGFR2 FGFR2 ADAMTS16 ADAMTS16 COL4A1 COL4A1 TMTC3 TMTC3 GLI2 GLI2 RDH10 RDH10 ACVR1 ACVR1 EYA1 EYA1 TIE1 TIE1 CXCL12 CXCL12 HHEX HHEX CXCR4 CXCR4 WNT6 WNT6 HHIP HHIP NFATC1 NFATC1 ENG ENG LAMA1 LAMA1 AREG AREG CSMD2 CSMD2 STK4 STK4 TBX2 TBX2 GZF1 GZF1 HS3ST3B1 HS3ST3B1 TGFB1 TGFB1 MKS1 MKS1 FAT4 FAT4 GPC3 GPC3 SEMA3E SEMA3E GBX2 GBX2 CELSR1 CELSR1 HOXA5 HOXA5 PAX2 PAX2 ILK ILK CSMD1 CSMD1 CTSZ CTSZ Mycn Mycn LRP5 LRP5 RASIP1 RASIP1 HNF1B HNF1B BMP7 BMP7 PAK1 PAK1 PKD1 PKD1 CTSH CTSH PKHD1 PKHD1 NRP1 NRP1 TMEM59L TMEM59L PML PML ESRP2 ESRP2 PXN PXN TIMELESS TIMELESS SRF SRF ESRP1 ESRP1 LRP6 LRP6 EXT1 EXT1 CTNNB1 CTNNB1 KDR KDR Ppp3r1 Ppp3r1 FOXA1 FOXA1 SHH SHH NFATC3 NFATC3 AR AR GREB1 GREB1 Fgf2 Fgf2 HOXA11 HOXA11 HS3ST3A1 HS3ST3A1 BCL2 BCL2 Spry2 Spry2 LAMA5 LAMA5 SMAD4 SMAD4 AGT AGT WT1 WT1 PSPN PSPN LHX1 LHX1 Notch4 Notch4 MED1 MED1 FGF10 FGF10 SIX1 SIX1 FLT1 FLT1 WNT9B WNT9B TNC TNC BMP2 BMP2 GDF7 GDF7 MET MET PGR PGR GDNF GDNF LOC101955349 LOC101955349 CTNNBIP1 CTNNBIP1 CSF1 CSF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXA2Forkhead box A2. (463 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
SPRY1Sprouty RTK signaling antagonist 1. (315 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
PHB2Prohibitin. (299 aa)
SOX9SRY-box transcription factor 9. (509 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
IHHIndian hedgehog signaling molecule. (379 aa)
RSPO2R-spondin 2. (243 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PLXND1Plexin D1. (1796 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1920 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1916 aa)
GDF2Growth differentiation factor 2. (429 aa)
Pitx2Homeobox protein. (325 aa)
LOC101964462Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
SALL1Spalt like transcription factor 1. (1313 aa)
GLI3GLI family zinc finger 3. (1582 aa)
TCF21Transcription factor 21. (179 aa)
Hmga2Uncharacterized protein. (109 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
DSPPDentin sialophosphoprotein. (1075 aa)
DCHS1Dachsous cadherin-related 1. (3293 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ETV4ETS variant 4. (486 aa)
TBX3T-box transcription factor 3. (744 aa)
NKX3-1NK3 homeobox 1. (144 aa)
ENSSTOP00000025781Guanylate kinase-like domain-containing protein. (243 aa)
TBX20T-box transcription factor 20. (446 aa)
PBX1PBX homeobox 1. (430 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
PAX8Paired box 8. (574 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (915 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NPNTNephronectin. (612 aa)
DAG1Dystroglycan 1. (895 aa)
IGF1Insulin like growth factor 1. (166 aa)
NCOA3Nuclear receptor coactivator. (1413 aa)
PTCH1Patched 1. (1450 aa)
VDRVitamin D receptor. (423 aa)
TFAP2CTranscription factor AP-2 gamma. (419 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
SLIT2Slit guidance ligand 2. (1559 aa)
TMEM67Transmembrane protein 67. (999 aa)
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1358 aa)
KDM5BLysine demethylase 5B. (1544 aa)
MSX2Msh homeobox 2. (267 aa)
EDN1Endothelin 1. (202 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GNA13G protein subunit alpha 13. (306 aa)
Clic4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (229 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
LOC101973790Uncharacterized protein. (311 aa)
VANGL2Vang-like protein. (547 aa)
SEMA5ASemaphorin 5A. (1074 aa)
NFATC4Nuclear factor of activated T cells 4. (890 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
EPHA2EPH receptor A2. (923 aa)
AhrUncharacterized protein. (848 aa)
SLC12A2Solute carrier family 12 member 2. (1108 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Pkd2EF-hand domain-containing protein. (892 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1218 aa)
COL4A1Collagen type IV alpha 1 chain. (1671 aa)
TMTC3Transmembrane O-mannosyltransferase targeting cadherins 3. (917 aa)
GLI2GLI family zinc finger 2. (1540 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
HHEXHematopoietically expressed homeobox. (272 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
HHIPHedgehog interacting protein. (700 aa)
NFATC1Nuclear factor of activated T cells 1. (941 aa)
ENGEndoglin. (463 aa)
LAMA1Laminin subunit alpha 1. (3004 aa)
AREGAmphiregulin. (252 aa)
CSMD2CUB and Sushi multiple domains 2. (3551 aa)
STK4Serine/threonine kinase 4. (488 aa)
TBX2T-box transcription factor 2. (712 aa)
GZF1GDNF inducible zinc finger protein 1. (713 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
FAT4FAT atypical cadherin 4. (4978 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (721 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2858 aa)
HOXA5Homeobox A5. (270 aa)
PAX2Paired box 2. (417 aa)
ILKIntegrin linked kinase. (452 aa)
CSMD1CUB and Sushi multiple domains 1. (3564 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
MycnBHLH domain-containing protein. (460 aa)
LRP5Uncharacterized protein. (1516 aa)
RASIP1Ras interacting protein 1. (963 aa)
HNF1BHNF1 homeobox B. (558 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4252 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4063 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
TMEM59LTransmembrane protein 59 like. (345 aa)
PMLPromyelocytic leukemia. (877 aa)
ESRP2Epithelial splicing regulatory protein 2. (709 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (424 aa)
TIMELESSTimeless circadian regulator. (1147 aa)
SRFSerum response factor. (505 aa)
ESRP1Epithelial splicing regulatory protein 1. (682 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CTNNB1Catenin beta 1. (781 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
Ppp3r1Uncharacterized protein. (169 aa)
FOXA1Forkhead box A1. (468 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
ARAndrogen receptor. (884 aa)
GREB1Uncharacterized protein. (1955 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
HOXA11Homeobox A11. (315 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (348 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
Spry2Uncharacterized protein. (315 aa)
LAMA5Laminin subunit alpha 5. (3474 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
WT1WT1 transcription factor. (523 aa)
PSPNPersephin. (158 aa)
LHX1LIM homeobox 1. (406 aa)
Notch4Uncharacterized protein. (1955 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
SIX1SIX homeobox 1. (284 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
TNCTenascin C. (2171 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GDF7Growth differentiation factor 7. (445 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
PGRProgesterone receptor. (932 aa)
GDNFGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (212 aa)
LOC101955349BHLH domain-containing protein. (454 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
CSF1Colony stimulating factor 1. (497 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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