(44 nodes) Brain morphogenesis network (Ictidomys tridecemlineatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ZNF335	Zinc finger protein 335. (1371 aa)
	HESX1	HESX homeobox 1. (184 aa)
	UCHL5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	CTNNA1	Catenin alpha 1. (906 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (920 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (411 aa)
	VPS51	VPS51 subunit of GARP complex. (781 aa)
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
	HHEX	Hematopoietically expressed homeobox. (272 aa)
	PCNT	Pericentrin. (3070 aa)
	DUOX2	Dual oxidase 2. (1517 aa)
	GBA	Glucosylceramidase. (516 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	PAX2	Paired box 2. (417 aa)
	PROP1	PROP paired-like homeobox 1. (227 aa)
	FANCD2	FA complementation group D2. (1276 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	IFT88	Intraflagellar transport 88. (825 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	GSX2	GS homeobox 2. (218 aa)
	I3MZY4_ICTTR	Uncharacterized protein. (356 aa)
	OTX2	Orthodenticle homeobox 2. (289 aa)
	OTX1	Orthodenticle homeobox 1. (355 aa)
	GDF7	Growth differentiation factor 7. (445 aa)
	I3N3K3_ICTTR	Uncharacterized protein. (81 aa)
	SPEF2	Sperm flagellar 2. (2162 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1645 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	Foxo3	Forkhead box O3. (673 aa)
	FBXW11	F-box and WD repeat domain containing 11. (553 aa)
	EMX1	Empty spiracles homeobox 1. (257 aa)
	Bbs1	BBS1 domain-containing protein. (594 aa)
	AFDN	Afadin, adherens junction formation factor. (1801 aa)
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	SLC4A10	Anion exchange protein. (1139 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	NF1	Neurofibromin 1. (2473 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	BBS4	Bardet-Biedl syndrome 4. (514 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (748 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
	GAK	Cyclin G associated kinase. (1322 aa)
	FANCC	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (578 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFDN	CDH2	ENSSTOP00000024154	ENSSTOP00000001936	Afadin, adherens junction formation factor.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.445
AFDN	CTNNA1	ENSSTOP00000024154	ENSSTOP00000000928	Afadin, adherens junction formation factor.	Catenin alpha 1.	0.862
AFDN	I3MZY4_ICTTR	ENSSTOP00000024154	ENSSTOP00000017680	Afadin, adherens junction formation factor.	Uncharacterized protein.	0.862
AFDN	I3N3K3_ICTTR	ENSSTOP00000024154	ENSSTOP00000018949	Afadin, adherens junction formation factor.	Uncharacterized protein.	0.862
AKT3	FBXW11	ENSSTOP00000009513	ENSSTOP00000022482	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	F-box and WD repeat domain containing 11.	0.512
AKT3	Foxo3	ENSSTOP00000009513	ENSSTOP00000022009	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.951
AKT3	GAK	ENSSTOP00000009513	ENSSTOP00000030676	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin G associated kinase.	0.515
AKT3	NF1	ENSSTOP00000009513	ENSSTOP00000027148	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Neurofibromin 1.	0.430
AKT3	PTEN	ENSSTOP00000009513	ENSSTOP00000015636	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.822
BBS2	BBS4	ENSSTOP00000028671	ENSSTOP00000028327	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4.	0.999
BBS2	Bbs1	ENSSTOP00000028671	ENSSTOP00000023809	Bardet-Biedl syndrome 2 protein homolog.	BBS1 domain-containing protein.	0.998
BBS2	IFT88	ENSSTOP00000028671	ENSSTOP00000013902	Bardet-Biedl syndrome 2 protein homolog.	Intraflagellar transport 88.	0.730
BBS2	MKKS	ENSSTOP00000028671	ENSSTOP00000012696	Bardet-Biedl syndrome 2 protein homolog.	McKusick-Kaufman syndrome.	0.533
BBS2	SMO	ENSSTOP00000028671	ENSSTOP00000010265	Bardet-Biedl syndrome 2 protein homolog.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.742
BBS4	BBS2	ENSSTOP00000028327	ENSSTOP00000028671	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS4	Bbs1	ENSSTOP00000028327	ENSSTOP00000023809	Bardet-Biedl syndrome 4.	BBS1 domain-containing protein.	0.999
BBS4	IFT88	ENSSTOP00000028327	ENSSTOP00000013902	Bardet-Biedl syndrome 4.	Intraflagellar transport 88.	0.463
BBS4	PCNT	ENSSTOP00000028327	ENSSTOP00000006861	Bardet-Biedl syndrome 4.	Pericentrin.	0.415
BBS4	SMO	ENSSTOP00000028327	ENSSTOP00000010265	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.725
Bbs1	BBS2	ENSSTOP00000023809	ENSSTOP00000028671	BBS1 domain-containing protein.	Bardet-Biedl syndrome 2 protein homolog.	0.998