STRINGSTRING
FN1 FN1 SHC4 SHC4 PAX6 PAX6 FGFR2 FGFR2 Lin28a Lin28a TBX1 TBX1 RDH10 RDH10 ACVR1 ACVR1 Hif1a Hif1a LIF LIF SEMA3D SEMA3D HHEX HHEX PHACTR4 PHACTR4 XRCC5 XRCC5 SEMA4C SEMA4C NELFB NELFB ANXA6 ANXA6 Rest Rest MSI2 MSI2 TAL1 TAL1 METTL5 METTL5 CITED2 CITED2 EPCAM EPCAM PAX3 PAX3 SOX8 SOX8 Fbxl17 Fbxl17 LMBR1L LMBR1L TCOF1 TCOF1 SEMA4G SEMA4G EDNRB EDNRB TBX2 TBX2 HTR2B HTR2B NRTN NRTN HOXB4 HOXB4 SLC9A1 SLC9A1 SEMA4B SEMA4B SEMA5B SEMA5B SEMA3E SEMA3E BBS12 BBS12 GBX2 GBX2 HOXA7 HOXA7 SMO SMO PAX2 PAX2 CORO1C CORO1C JARID2 JARID2 MYOCD MYOCD ELL3 ELL3 HNF1B HNF1B PHF19 PHF19 ISL1 ISL1 ITGB1 ITGB1 FZD1 FZD1 NRP1 NRP1 TP63 TP63 CDK6 CDK6 OTUD5 OTUD5 SRF SRF MAPK1 MAPK1 SEMA6D SEMA6D LRP6 LRP6 OSR1 OSR1 KLHL12 KLHL12 EXT1 EXT1 CYP26A1 CYP26A1 BMPR1A BMPR1A CTNNB1 CTNNB1 GSC GSC SEMA3F SEMA3F FOXA1 FOXA1 SHH SHH NAP1L2 NAP1L2 SP7 SP7 Fgf2 Fgf2 MLLT3 MLLT3 SFRP1 SFRP1 Pou5f1 Pou5f1 EPOP EPOP LAMA5 LAMA5 PEF1 PEF1 SMAD4 SMAD4 Nanog Nanog FOXC2 FOXC2 SETD2 SETD2 Dnmt3l Dnmt3l SOX10 SOX10 SEMA7A SEMA7A ZFP36 ZFP36 KBTBD8 KBTBD8 SOX18 SOX18 SIX1 SIX1 OVOL2 OVOL2 WNT10A WNT10A BATF BATF GATA6 GATA6 TBXT TBXT TCF7L1 TCF7L1 EFNB1 EFNB1 EOMES EOMES WNT7A WNT7A I3N4S4_ICTTR I3N4S4_ICTTR GDNF GDNF DMRTA2 DMRTA2 ZNF281 ZNF281 TP53 TP53 PHOX2B PHOX2B ZIC3 ZIC3 HES1 HES1 I3N6Q6_ICTTR I3N6Q6_ICTTR GPM6A GPM6A SNAI2 SNAI2 WNT3 WNT3 HAND2 HAND2 SOX9 SOX9 EDNRA EDNRA I3NA52_ICTTR I3NA52_ICTTR FGF19 FGF19 HOXD4 HOXD4 SEMA6B SEMA6B GREM1 GREM1 WNT7B WNT7B SOX17 SOX17 FOXO4 FOXO4 Pitx2 Pitx2 MAPK14 MAPK14 Hmga2 Hmga2 DICER1 DICER1 PUM1 PUM1 SEMA6A SEMA6A SEMA3B SEMA3B Ggt1 Ggt1 ETV4 ETV4 UFL1 UFL1 TBX3 TBX3 FOLR1 FOLR1 PTPRC PTPRC JAG1 JAG1 PSMD11 PSMD11 PDCD6 PDCD6 TFAP2A TFAP2A ERCC2 ERCC2 ZEB2 ZEB2 PHF5A PHF5A SEMA3C SEMA3C NRP2 NRP2 KITLG KITLG RUNX2 RUNX2 ENSSTOP00000029470 ENSSTOP00000029470 EZH2 EZH2 SETD6 SETD6 Cfl1 Cfl1 MTF2 MTF2 SEMA4A SEMA4A MEF2C MEF2C FAM172A FAM172A ENSSTOP00000031278 ENSSTOP00000031278 LOC101966144 LOC101966144 CYP26C1 CYP26C1 NRG1 NRG1 EDN3 EDN3 SEMA4F SEMA4F SH2B3 SH2B3 SEMA4D SEMA4D MAPK3 MAPK3 Cdc42 Cdc42 KIT KIT FRZB FRZB RADIL RADIL SEMA6C SEMA6C EDN1 EDN1 MSX2 MSX2 HESX1 HESX1 SEMA3G SEMA3G ALDH1A2 ALDH1A2 L3MBTL2 L3MBTL2 ERBB4 ERBB4 CHD2 CHD2 RET RET NOLC1 NOLC1 CDH2 CDH2 KRT10 KRT10 SFRP2 SFRP2 SEMA5A SEMA5A TGFB2 TGFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FN1Fibronectin 1. (2474 aa)
SHC4SHC adaptor protein 4. (630 aa)
PAX6Paired box 6. (436 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
Lin28aCCHC-type domain-containing protein. (210 aa)
TBX1T-box transcription factor 1. (406 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
Hif1aUncharacterized protein. (821 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (735 aa)
HHEXHematopoietically expressed homeobox. (272 aa)
PHACTR4Phosphatase and actin regulator. (712 aa)
XRCC5X-ray repair cross complementing 5. (734 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (831 aa)
NELFBNegative elongation factor complex member B. (628 aa)
ANXA6Annexin. (673 aa)
RestUncharacterized protein. (328 aa)
MSI2Musashi RNA binding protein 2. (283 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
METTL5Methyltransferase like 5. (209 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (274 aa)
EPCAMEpithelial cell adhesion molecule. (290 aa)
PAX3Paired box 3. (484 aa)
SOX8SRY-box transcription factor 8. (466 aa)
Fbxl17Uncharacterized protein. (220 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (488 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1455 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (839 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
TBX2T-box transcription factor 2. (712 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
NRTNNeurturin. (197 aa)
HOXB4Homeobox B4. (256 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (823 aa)
SEMA5BSemaphorin 5B. (1093 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (721 aa)
BBS12Bardet-Biedl syndrome 12. (708 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
HOXA7Homeobox A7. (232 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
PAX2Paired box 2. (417 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1226 aa)
MYOCDMyocardin. (894 aa)
ELL3Elongation factor for RNA polymerase II 3. (380 aa)
HNF1BHNF1 homeobox B. (558 aa)
PHF19PHD finger protein 19. (583 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (643 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
OTUD5OTU deubiquitinase 5. (569 aa)
SRFSerum response factor. (505 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1061 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
KLHL12Kelch like family member 12. (568 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CTNNB1Catenin beta 1. (781 aa)
GSCGoosecoid homeobox. (256 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
FOXA1Forkhead box A1. (468 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
NAP1L2Nucleosome assembly protein 1 like 2; Belongs to the nucleosome assembly protein (NAP) family. (458 aa)
SP7Sp7 transcription factor. (428 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
MLLT3MLLT3 super elongation complex subunit. (551 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
Pou5f1POU domain protein. (360 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
LAMA5Laminin subunit alpha 5. (3474 aa)
PEF1Penta-EF-hand domain containing 1. (279 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NanogHomeobox domain-containing protein. (306 aa)
FOXC2Forkhead box C2. (500 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2525 aa)
Dnmt3lPHD-type domain-containing protein. (358 aa)
SOX10SRY-box transcription factor 10. (466 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
ZFP36ZFP36 ring finger protein. (324 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (600 aa)
SOX18SRY-box transcription factor 18. (383 aa)
SIX1SIX homeobox 1. (284 aa)
OVOL2Ovo like zinc finger 2. (276 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
GATA6GATA binding protein 6. (593 aa)
TBXTT-box transcription factor T. (435 aa)
TCF7L1Transcription factor 7 like 1. (557 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (345 aa)
EOMESEomesodermin. (702 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
I3N4S4_ICTTRUncharacterized protein. (162 aa)
GDNFGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (212 aa)
DMRTA2DMRT like family A2. (535 aa)
ZNF281Zinc finger protein 281. (890 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
PHOX2BPaired like homeobox 2B. (252 aa)
ZIC3Zic family member 3. (466 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
I3N6Q6_ICTTRADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (160 aa)
GPM6AGlycoprotein M6A. (278 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SOX9SRY-box transcription factor 9. (509 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
I3NA52_ICTTRUncharacterized protein. (90 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
HOXD4Homeobox D4. (252 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (801 aa)
GREM1Gremlin. (184 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
SOX17SRY-box transcription factor 17. (415 aa)
FOXO4Forkhead box O4. (505 aa)
Pitx2Homeobox protein. (325 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
Hmga2Uncharacterized protein. (109 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
PUM1Pumilio RNA binding family member 1. (1188 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (778 aa)
Ggt1Uncharacterized protein. (568 aa)
ETV4ETS variant 4. (486 aa)
UFL1UFM1 specific ligase 1. (792 aa)
TBX3T-box transcription factor 3. (744 aa)
FOLR1Folate receptor alpha. (255 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1180 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PDCD6Programmed cell death 6. (191 aa)
TFAP2ATranscription factor AP-2 alpha. (477 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1249 aa)
PHF5APHD finger protein 5A. (110 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (520 aa)
ENSSTOP00000029470POU-specific domain-containing protein. (311 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (519 aa)
Cfl1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (203 aa)
MTF2Metal response element binding transcription factor 2. (593 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (758 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
ENSSTOP00000031278CSP domain-containing protein. (186 aa)
LOC101966144Uncharacterized protein. (147 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (518 aa)
NRG1Neuregulin 1. (700 aa)
EDN3Endothelin 3. (197 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
SH2B3SH2B adaptor protein 3. (429 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (747 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
Cdc42Uncharacterized protein. (191 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
FRZBFrizzled related protein. (325 aa)
RADILRap associating with DIL domain. (1070 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (866 aa)
EDN1Endothelin 1. (202 aa)
MSX2Msh homeobox 2. (267 aa)
HESX1HESX homeobox 1. (184 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (773 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
L3MBTL2L3MBTL histone methyl-lysine binding protein 2. (706 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
CHD2Uncharacterized protein. (1828 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1112 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (703 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (920 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (563 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SEMA5ASemaphorin 5A. (1074 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (16%) [HD]