STRINGSTRING
CARMIL2 CARMIL2 TWSG1 TWSG1 TNFRSF1B TNFRSF1B IL18 IL18 LEP LEP SHH SHH TSPAN32 TSPAN32 ATAD5 ATAD5 Tnfrsf13b Tnfrsf13b BCL2 BCL2 I3MVL6_ICTTR I3MVL6_ICTTR PELI1 PELI1 CCDC88B CCDC88B LMO1 LMO1 TYROBP TYROBP RAC2 RAC2 FOXJ1 FOXJ1 MAPK8IP1 MAPK8IP1 LOC101968601 LOC101968601 TLR4 TLR4 I3N090_ICTTR I3N090_ICTTR AIF1 AIF1 FGF10 FGF10 NCKAP1L NCKAP1L MNDA MNDA CD28 CD28 LOC101960206 LOC101960206 ZBTB7B ZBTB7B Vcam1 Vcam1 PRKCQ PRKCQ IGF2 IGF2 EFNB1 EFNB1 CD276 CD276 MZB1 MZB1 LOC101972772 LOC101972772 CDKN1A CDKN1A SFTPD SFTPD Fcgr2b Fcgr2b HES1 HES1 GPR183 GPR183 CTLA4 CTLA4 IL2RA IL2RA LRRC32 LRRC32 PDE5A PDE5A IL27 IL27 ANXA1 ANXA1 IHH IHH WNT3A WNT3A TNFSF13B TNFSF13B LOC101959667 LOC101959667 TNFRSF21 TNFRSF21 GAL GAL MARCHF7 MARCHF7 SLC39A10 SLC39A10 LOC101972479 LOC101972479 DLG5 DLG5 LGALS3 LGALS3 CD4 CD4 CD40 CD40 I3NF27_ICTTR I3NF27_ICTTR BST1 BST1 LOC101961439 LOC101961439 LAPTM5 LAPTM5 PLA2G2F PLA2G2F Rps3 Rps3 FADD FADD BCL6 BCL6 GLMN GLMN TGFBR2 TGFBR2 AGER AGER ENSSTOP00000025781 ENSSTOP00000025781 ENSSTOP00000025794 ENSSTOP00000025794 PKN1 PKN1 CD320 CD320 PTPRC PTPRC EPHB2 EPHB2 CHRNB2 CHRNB2 ENSSTOP00000027615 ENSSTOP00000027615 KITLG KITLG Lgals7 Lgals7 Tnfrsf13c Tnfrsf13c NFATC2 NFATC2 LYN LYN ENSSTOP00000029572 ENSSTOP00000029572 PTPN6 PTPN6 IGF1 IGF1 SOS1 SOS1 IL7 IL7 MEF2C MEF2C ZNF335 ZNF335 IL21 IL21 LST1 LST1 VAV3 VAV3 GPAM GPAM CD81 CD81 ARG2 ARG2 DNAJA3 DNAJA3 SELENOK SELENOK BLK BLK ZNHIT1 ZNHIT1 CLEC4G CLEC4G NCK2 NCK2 BMP4 BMP4 LOC101955676 LOC101955676 NCK1 NCK1 IL1B IL1B RIPK3 RIPK3 Cd86 Cd86 VSIG4 VSIG4 ITGAL ITGAL CCL19 CCL19 Ahr Ahr TYK2 TYK2 HLA-DPA1 HLA-DPA1 HLA-DPB1 HLA-DPB1 SCRIB SCRIB TFRC TFRC IKZF3 IKZF3 BTN1A1 BTN1A1 FOXP3 FOXP3 Zp3 Zp3 ATM ATM BTK BTK I3M4W8_ICTTR I3M4W8_ICTTR IL12B IL12B BLM BLM IL6ST IL6ST Ndfip1 Ndfip1 IL23R IL23R IL15 IL15 SYK SYK CD40LG CD40LG RASSF5 RASSF5 IL10 IL10 SLC4A1 SLC4A1 JAK2 JAK2 STAT5B STAT5B STAT5A STAT5A Dhps Dhps SLAMF1 SLAMF1 TRAF6 TRAF6 VTCN1 VTCN1 CD6 CD6 Card11 Card11 JAK3 JAK3 IL13 IL13 SASH3 SASH3 CORO1A CORO1A GPNMB GPNMB IL27RA IL27RA CD74 CD74 MPL MPL PLA2G2D PLA2G2D SDC4 SDC4 LOC101968486 LOC101968486 LOC101968188 LOC101968188 IRF1 IRF1 TGFB1 TGFB1 TIRAP TIRAP CD22 CD22 SCGB1A1 SCGB1A1 TNFSF18 TNFSF18 TCF3 TCF3 BTNL2 BTNL2 TMEM131L TMEM131L ZAP70 ZAP70 LRRC1 LRRC1 IGFBP2 IGFBP2 INPP5D INPP5D Cd59 Cd59 PPP3CA PPP3CA ADK ADK CBLB CBLB SLC7A1 SLC7A1 PRKAR1A PRKAR1A IDO1 IDO1 PYCARD PYCARD MYD88 MYD88 EPO EPO ZC3H12D ZC3H12D SH3RF1 SH3RF1 I3MMQ2_ICTTR I3MMQ2_ICTTR LOC101970885 LOC101970885 IL12A IL12A ITCH ITCH RIPK2 RIPK2 SPTA1 SPTA1 PRNP PRNP CLCF1 CLCF1 PAWR PAWR CD274 CD274 PDCD1LG2 PDCD1LG2 IL23A IL23A RC3H1 RC3H1 IL2 IL2 I3MQY6_ICTTR I3MQY6_ICTTR CTNNB1 CTNNB1 Lgals9 Lgals9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CARMIL2Capping protein regulator and myosin 1 linker 2. (1403 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
TNFRSF1BTNF receptor superfamily member 1B. (436 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (314 aa)
ATAD5ATPase family AAA domain containing 5. (1897 aa)
Tnfrsf13bUncharacterized protein. (120 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
CCDC88BCoiled-coil domain containing 88B. (1234 aa)
LMO1LIM domain only 1. (156 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
RAC2Rac family small GTPase 2. (192 aa)
FOXJ1Forkhead box J1. (421 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (697 aa)
LOC101968601Uncharacterized protein. (80 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
MNDAMyeloid cell nuclear differentiation antigen. (431 aa)
CD28CD28 molecule. (221 aa)
LOC101960206Uncharacterized protein. (207 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (539 aa)
Vcam1Vascular cell adhesion molecule 1. (657 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
IGF2Insulin like growth factor 2. (180 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (345 aa)
CD276CD276 molecule. (316 aa)
MZB1Marginal zone B and B1 cell specific protein. (188 aa)
LOC101972772A_deaminase domain-containing protein. (352 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
SFTPDSurfactant protein D. (375 aa)
Fcgr2bUncharacterized protein. (341 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (357 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (226 aa)
IL2RAInterleukin 2 receptor subunit alpha. (251 aa)
LRRC32Leucine rich repeat containing 32. (663 aa)
PDE5APhosphodiesterase. (822 aa)
IL27Interleukin 27. (240 aa)
ANXA1Annexin. (346 aa)
IHHIndian hedgehog signaling molecule. (379 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (280 aa)
LOC101959667Ig-like domain-containing protein. (272 aa)
TNFRSF21TNF receptor superfamily member 21. (654 aa)
GALGalanin and GMAP prepropeptide. (96 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (707 aa)
SLC39A10Solute carrier family 39 member 10. (830 aa)
LOC101972479A_deaminase domain-containing protein. (338 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1920 aa)
LGALS3Galectin. (220 aa)
CD4CD4 molecule. (451 aa)
CD40CD40 molecule. (284 aa)
I3NF27_ICTTRRas-GAP domain-containing protein. (574 aa)
BST1Bone marrow stromal cell antigen 1. (311 aa)
LOC101961439TIR domain-containing protein. (1051 aa)
LAPTM5Lysosomal protein transmembrane 5. (219 aa)
PLA2G2FPhospholipase A(2). (209 aa)
Rps3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (244 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BCL6BCL6 transcription repressor. (706 aa)
GLMNGlomulin, FKBP associated protein. (596 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
AGERAdvanced glycosylation end-product specific receptor. (450 aa)
ENSSTOP00000025781Guanylate kinase-like domain-containing protein. (243 aa)
ENSSTOP00000025794Uncharacterized protein. (78 aa)
PKN1Protein kinase N1. (947 aa)
CD320CD320 molecule. (258 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1180 aa)
EPHB2EPH receptor B2. (978 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (599 aa)
ENSSTOP00000027615Uncharacterized protein. (247 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
Lgals7Galectin. (139 aa)
Tnfrsf13cUncharacterized protein. (104 aa)
NFATC2Nuclear factor of activated T cells 2. (844 aa)
LYNTyrosine-protein kinase. (512 aa)
ENSSTOP00000029572Uncharacterized protein. (198 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
IGF1Insulin like growth factor 1. (166 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (159 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ZNF335Zinc finger protein 335. (1371 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
LST1Leukocyte specific transcript 1. (85 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (827 aa)
CD81Tetraspanin. (214 aa)
ARG2Arginase. (354 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (479 aa)
SELENOKSelenoprotein K. (91 aa)
BLKTyrosine-protein kinase. (499 aa)
ZNHIT1Zinc finger HIT-type containing 1. (155 aa)
CLEC4GC-type lectin domain family 4 member G. (295 aa)
NCK2Cytoplasmic protein. (380 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
LOC101955676RING-type domain-containing protein. (326 aa)
NCK1Cytoplasmic protein. (377 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (491 aa)
Cd86Ig-like domain-containing protein. (289 aa)
VSIG4V-set and immunoglobulin domain containing 4. (399 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1149 aa)
CCL19C-C motif chemokine. (135 aa)
AhrUncharacterized protein. (848 aa)
TYK2Tyrosine-protein kinase. (1194 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (288 aa)
SCRIBScribble planar cell polarity protein. (1546 aa)
TFRCTransferrin receptor. (760 aa)
IKZF3IKAROS family zinc finger 3. (509 aa)
BTN1A1Butyrophilin subfamily 1 member A1. (528 aa)
FOXP3Forkhead box P3. (431 aa)
Zp3ZP domain-containing protein. (319 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
BTKTyrosine-protein kinase. (659 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
BLMBLM RecQ like helicase. (1414 aa)
IL6STInterleukin 6 signal transducer. (928 aa)
Ndfip1Nedd4 family interacting protein 1. (229 aa)
IL23RInterleukin 23 receptor. (644 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (134 aa)
SYKTyrosine-protein kinase. (626 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (259 aa)
RASSF5Ras association domain family member 5. (313 aa)
IL10Interleukin 10. (178 aa)
SLC4A1Anion exchange protein. (917 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
STAT5BSignal transducer and activator of transcription. (765 aa)
STAT5ASignal transducer and activator of transcription. (773 aa)
DhpsUncharacterized protein. (369 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (335 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
CD6CD6 molecule. (670 aa)
Card11Uncharacterized protein. (1152 aa)
JAK3Tyrosine-protein kinase. (1042 aa)
IL13Interleukin 13. (130 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
GPNMBGlycoprotein nmb. (556 aa)
IL27RAInterleukin 27 receptor subunit alpha. (569 aa)
CD74CD74 molecule. (279 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (648 aa)
PLA2G2DPhospholipase A(2). (145 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (176 aa)
LOC101968486Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
LOC101968188Ig-like domain-containing protein. (266 aa)
IRF1Interferon regulatory factor. (326 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TIRAPTIR domain containing adaptor protein. (222 aa)
CD22CD22 molecule. (806 aa)
SCGB1A1Secretoglobin family 1A member 1. (93 aa)
TNFSF18TNF superfamily member 18. (172 aa)
TCF3Transcription factor 3. (681 aa)
BTNL2Butyrophilin like 2. (475 aa)
TMEM131LTransmembrane 131 like. (1308 aa)
ZAP70Tyrosine-protein kinase. (608 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
IGFBP2Insulin like growth factor binding protein 2. (308 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1213 aa)
Cd59UPAR/Ly6 domain-containing protein. (131 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
ADKAdenosine kinase. (362 aa)
CBLBCbl proto-oncogene B. (985 aa)
SLC7A1Solute carrier family 7 member 1. (629 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (402 aa)
PYCARDPYD and CARD domain containing. (194 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (518 aa)
SH3RF1SH3 domain containing ring finger 1. (895 aa)
I3MMQ2_ICTTRUncharacterized protein. (384 aa)
LOC101970885SCY domain-containing protein. (113 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
ITCHE3 ubiquitin-protein ligase. (855 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2417 aa)
PRNPMajor prion protein; Belongs to the prion family. (247 aa)
CLCF1Cardiotrophin like cytokine factor 1. (219 aa)
PAWRPro-apoptotic WT1 regulator. (340 aa)
CD274CD274 molecule. (293 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (259 aa)
IL23AInterleukin 23 subunit alpha. (185 aa)
RC3H1Ring finger and CCCH-type domains 1. (1130 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
I3MQY6_ICTTRUncharacterized protein. (238 aa)
CTNNB1Catenin beta 1. (781 aa)
Lgals9Galectin. (352 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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