STRINGSTRING
MEN1 MEN1 ENSSTOP00000028075 ENSSTOP00000028075 MTSS1 MTSS1 INTU INTU ATP5F1A ATP5F1A ESR2 ESR2 Krit1 Krit1 MEF2C MEF2C PTCH1 PTCH1 DAB2 DAB2 APC APC MCC MCC VDR VDR CDH1 CDH1 ENSSTOP00000032619 ENSSTOP00000032619 FGFR3 FGFR3 NUPR1 NUPR1 Aqp11 Aqp11 FGFR2 FGFR2 DRD2 DRD2 PAX6 PAX6 TBC1D31 TBC1D31 DLL4 DLL4 STK11 STK11 TINF2 TINF2 SFRP2 SFRP2 NFIB NFIB IL26 IL26 SMO SMO THBS1 THBS1 BMP4 BMP4 GATA3 GATA3 RB1 RB1 ROBO1 ROBO1 ACVRL1 ACVRL1 MAGED1 MAGED1 CNMD CNMD WNT10B WNT10B IFT122 IFT122 A4GNT A4GNT IL12B IL12B B4GALT1 B4GALT1 I3M6A8_ICTTR I3M6A8_ICTTR CASK CASK ATOH8 ATOH8 SPARC SPARC EFNB2 EFNB2 CTSV CTSV AIMP1 AIMP1 Nlrc3 Nlrc3 STAT1 STAT1 TGFB1 TGFB1 GPC3 GPC3 IFT52 IFT52 RAP1GAP RAP1GAP CPB2 CPB2 TGFB2 TGFB2 Rida Rida DUSP10 DUSP10 XDH XDH PTPRK PTPRK FLCN FLCN PPARG PPARG TNF TNF TSC2 TSC2 IFT74 IFT74 TGFBR1 TGFBR1 IFT57 IFT57 CDK6 CDK6 ATF2 ATF2 RGN RGN SYNJ2BP SYNJ2BP IL12A IL12A WDR13 WDR13 SFN SFN KDF1 KDF1 LRP6 LRP6 LIMS2 LIMS2 IFT88 IFT88 NKX2-8 NKX2-8 ZEB1 ZEB1 CDKN1B CDKN1B AR AR EAF2 EAF2 CAV1 CAV1 TGFBR3 TGFBR3 ALOX5 ALOX5 PTEN PTEN NPPB NPPB LOC101955809 LOC101955809 SFRP1 SFRP1 VASH1 VASH1 HPN HPN GKN3P GKN3P KRT4 KRT4 MED1 MED1 RUNX1 RUNX1 SAV1 SAV1 FLT1 FLT1 DAB2IP DAB2IP WDR77 WDR77 IFT80 IFT80 SULF1 SULF1 PHOX2B PHOX2B CDC73 CDC73 I3N729_ICTTR I3N729_ICTTR Pdcd10 Pdcd10 SNAI2 SNAI2 DLK1 DLK1 ATP5IF1 ATP5IF1 WNT5A WNT5A PHB2 PHB2 CDKN2B CDKN2B SOX9 SOX9 SERPINF1 SERPINF1 Lims1 Lims1 PTN PTN RGCC RGCC CAV2 CAV2 GDF2 GDF2 IRF6 IRF6 GDF5 GDF5 LOC101963282 LOC101963282 TNMD TNMD PPARD PPARD LOC101968945 LOC101968945 GHRL GHRL APOH APOH MMRN2 MMRN2 PEX2 PEX2 RUNX3 RUNX3 ETV4 ETV4 AGER AGER NKX3-1 NKX3-1 PTPRM PTPRM CD109 CD109 NF1 NF1 B2M B2M ENSSTOP00000027321 ENSSTOP00000027321 IFT172 IFT172 STK3 STK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MEN1Menin 1. (616 aa)
ENSSTOP00000028075Uncharacterized protein. (77 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
INTUInturned planar cell polarity protein. (942 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
ESR2Estrogen receptor 2. (525 aa)
Krit1Uncharacterized protein. (736 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
PTCH1Patched 1. (1450 aa)
DAB2DAB adaptor protein 2. (767 aa)
APCAPC regulator of WNT signaling pathway. (2865 aa)
MCCMCC regulator of WNT signaling pathway. (1019 aa)
VDRVitamin D receptor. (423 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
ENSSTOP00000032619Uncharacterized protein. (132 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (81 aa)
Aqp11Uncharacterized protein. (200 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PAX6Paired box 6. (436 aa)
TBC1D31TBC1 domain family member 31. (1068 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
TINF2TERF1 interacting nuclear factor 2. (449 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
IL26Interleukin 26. (173 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
THBS1Thrombospondin 1. (1182 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GATA3GATA binding protein 3. (444 aa)
RB1RB transcriptional corepressor 1. (957 aa)
ROBO1Roundabout guidance receptor 1. (1587 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MAGED1MAGE family member D1. (783 aa)
CNMDChondromodulin. (334 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
IFT122Intraflagellar transport 122. (1118 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (341 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
I3M6A8_ICTTRUncharacterized protein. (968 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (930 aa)
ATOH8Atonal bHLH transcription factor 8. (322 aa)
SPARCSecreted protein acidic and cysteine rich. (304 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (334 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (332 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (321 aa)
Nlrc3Uncharacterized protein. (397 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
IFT52Intraflagellar transport 52. (425 aa)
RAP1GAPRAP1 GTPase activating protein. (728 aa)
CPB2Carboxypeptidase B2. (423 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RidaUncharacterized protein. (137 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
XDHXanthine dehydrogenase. (1300 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1392 aa)
FLCNFolliculin. (579 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TSC2TSC complex subunit 2. (1745 aa)
IFT74Intraflagellar transport 74. (600 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
IFT57Intraflagellar transport 57. (429 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
RGNRegucalcin. (299 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
WDR13WD repeat domain 13. (473 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (366 aa)
IFT88Intraflagellar transport 88. (825 aa)
NKX2-8NK2 homeobox 8. (233 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1123 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ARAndrogen receptor. (884 aa)
EAF2ELL associated factor 2. (263 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
ALOX5Arachidonate 5-lipoxygenase. (663 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NPPBUncharacterized protein. (132 aa)
LOC101955809Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1335 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
VASH1Vasohibin 1. (366 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
GKN3PGastrokine 3, pseudogene. (191 aa)
KRT4Keratin 4; Belongs to the intermediate filament family. (517 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (467 aa)
SAV1Salvador family WW domain containing protein 1. (335 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
DAB2IPDAB2 interacting protein. (1148 aa)
WDR77WD repeat domain 77. (342 aa)
IFT80Intraflagellar transport 80. (777 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
PHOX2BPaired like homeobox 2B. (252 aa)
CDC73Cell division cycle 73. (531 aa)
I3N729_ICTTRSEA domain-containing protein. (225 aa)
Pdcd10Programmed cell death 10. (212 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
DLK1Delta like non-canonical Notch ligand 1. (383 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
PHB2Prohibitin. (299 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (162 aa)
SOX9SRY-box transcription factor 9. (509 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (417 aa)
Lims1LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (399 aa)
PTNPleiotrophin. (142 aa)
RGCCRegulator of cell cycle. (161 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
GDF2Growth differentiation factor 2. (429 aa)
IRF6Interferon regulatory factor 6. (467 aa)
GDF5Growth differentiation factor 5. (495 aa)
LOC101963282Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (268 aa)
TNMDTenomodulin. (317 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
LOC101968945Uncharacterized protein; Belongs to the peptidase C1 family. (339 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
APOHApolipoprotein H. (306 aa)
MMRN2Multimerin 2. (955 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
RUNX3RUNX family transcription factor 3. (419 aa)
ETV4ETS variant 4. (486 aa)
AGERAdvanced glycosylation end-product specific receptor. (450 aa)
NKX3-1NK3 homeobox 1. (144 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1507 aa)
CD109CD109 molecule. (1235 aa)
NF1Neurofibromin 1. (2473 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (123 aa)
ENSSTOP00000027321Uncharacterized protein. (207 aa)
IFT172Intraflagellar transport 172. (1755 aa)
STK3Serine/threonine kinase 3. (491 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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