(67 nodes) Regulation of defense response to virus network (Ictidomys tridecemlineatus)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC101960762	RING-type domain-containing protein. (427 aa)
	TSPAN32	Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (314 aa)
	SIN3A	SIN3 transcription regulator family member A. (1274 aa)
	ILRUN	Inflammation and lipid regulator with UBA-like and NBR1-like domains. (291 aa)
	I3MS10_ICTTR	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (311 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ZDHHC1	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (485 aa)
	DHX9	DExH-box helicase 9. (1328 aa)
	IL23A	Interleukin 23 subunit alpha. (185 aa)
	TKFC	Triokinase and FMN cyclase. (578 aa)
	PQBP1	Polyglutamine binding protein 1. (265 aa)
	ENSSTOP00000029147	Uncharacterized protein. (299 aa)
	NLRX1	NLR family member X1. (975 aa)
	TSPAN6	Tetraspanin. (245 aa)
	Ppm1b	PPM-type phosphatase domain-containing protein. (479 aa)
	TARBP2	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
	Cgas	Mab-21 domain-containing protein. (305 aa)
	TRIM38	Tripartite motif containing 38. (475 aa)
	I3MQC5_ICTTR	HECT domain-containing protein. (387 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1631 aa)
	MAVS	Mitochondrial antiviral signaling protein. (509 aa)
	GPATCH3	G-patch domain containing 3. (524 aa)
	ITCH	E3 ubiquitin-protein ligase. (855 aa)
	SEC14L1	SEC14 like lipid binding 1. (719 aa)
	DTX3L	Deltex E3 ubiquitin ligase 3L. (715 aa)
	PARP9	Poly(ADP-ribose) polymerase family member 9. (820 aa)
	PYCARD	PYD and CARD domain containing. (194 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	STAT1	Signal transducer and activator of transcription. (750 aa)
	MMP12	Matrix metallopeptidase 12. (477 aa)
	AIM2	Absent in melanoma 2. (349 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (609 aa)
	ELMOD2	ELMO domain containing 2. (260 aa)
	RIOK3	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
	Traf3ip2	SEFIR domain-containing protein. (109 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (134 aa)
	ZC3HAV1	Zinc finger CCCH-type containing, antiviral 1. (800 aa)
	IL23R	Interleukin 23 receptor. (644 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
	FOXP3	Forkhead box P3. (431 aa)
	Pcbp2	Poly(rC) binding protein 2. (362 aa)
	C1QBP	Complement C1q binding protein. (281 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1521 aa)
	UFD1	Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
	SELENOK	Selenoprotein K. (91 aa)
	DHX58	DExH-box helicase 58. (678 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	TRIM6	Tripartite motif containing 6. (469 aa)
	RNF125	Ring finger protein 125. (232 aa)
	HTRA1	HtrA serine peptidase 1. (424 aa)
	TRAF3IP2	TRAF3 interacting protein 2. (476 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	FGL2	Fibrinogen like 2. (439 aa)
	ENSSTOP00000025773	Uncharacterized protein. (305 aa)
	Rnf26	RING-type domain-containing protein. (422 aa)
	IFNLR1	Interferon lambda receptor 1. (530 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (599 aa)
	IL27	Interleukin 27. (240 aa)
	RNF216	Ring finger protein 216. (912 aa)
	TRIM44	Tripartite motif containing 44. (343 aa)
	CD37	Tetraspanin. (306 aa)
	STING1	Transmembrane protein 173. (379 aa)
	TRAF3IP1	TRAF3 interacting protein 1. (649 aa)
	NPLOC4	NPL4 homolog, ubiquitin recognition factor. (603 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	Cgas	ENSSTOP00000007285	ENSSTOP00000032196	Absent in melanoma 2.	Mab-21 domain-containing protein.	0.567
AIM2	DDX58	ENSSTOP00000007285	ENSSTOP00000006269	Absent in melanoma 2.	DExD/H-box helicase 58.	0.589
AIM2	IL1B	ENSSTOP00000007285	ENSSTOP00000002047	Absent in melanoma 2.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.520
AIM2	PYCARD	ENSSTOP00000007285	ENSSTOP00000012013	Absent in melanoma 2.	PYD and CARD domain containing.	0.992
AIM2	STING1	ENSSTOP00000007285	ENSSTOP00000017977	Absent in melanoma 2.	Transmembrane protein 173.	0.774
ATG12	ATG5	ENSSTOP00000010542	ENSSTOP00000014775	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	DDX58	ENSSTOP00000010542	ENSSTOP00000006269	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExD/H-box helicase 58.	0.945
ATG12	DHX58	ENSSTOP00000010542	ENSSTOP00000005836	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExH-box helicase 58.	0.830
ATG12	ILRUN	ENSSTOP00000010542	ENSSTOP00000014941	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Inflammation and lipid regulator with UBA-like and NBR1-like domains.	0.412
ATG12	MAVS	ENSSTOP00000010542	ENSSTOP00000013856	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral signaling protein.	0.955
ATG12	NLRX1	ENSSTOP00000010542	ENSSTOP00000030193	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.726
ATG5	ATG12	ENSSTOP00000014775	ENSSTOP00000010542	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	DDX58	ENSSTOP00000014775	ENSSTOP00000006269	Autophagy protein 5; Involved in autophagic vesicle formation.	DExD/H-box helicase 58.	0.945
ATG5	DHX58	ENSSTOP00000014775	ENSSTOP00000005836	Autophagy protein 5; Involved in autophagic vesicle formation.	DExH-box helicase 58.	0.829
ATG5	ILRUN	ENSSTOP00000014775	ENSSTOP00000014941	Autophagy protein 5; Involved in autophagic vesicle formation.	Inflammation and lipid regulator with UBA-like and NBR1-like domains.	0.449
ATG5	MAVS	ENSSTOP00000014775	ENSSTOP00000013856	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral signaling protein.	0.955
ATG5	NLRX1	ENSSTOP00000014775	ENSSTOP00000030193	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.764
ATG5	STAT1	ENSSTOP00000014775	ENSSTOP00000007745	Autophagy protein 5; Involved in autophagic vesicle formation.	Signal transducer and activator of transcription.	0.509
Cgas	AIM2	ENSSTOP00000032196	ENSSTOP00000007285	Mab-21 domain-containing protein.	Absent in melanoma 2.	0.567
Cgas	DDX58	ENSSTOP00000032196	ENSSTOP00000006269	Mab-21 domain-containing protein.	DExD/H-box helicase 58.	0.546