STRINGSTRING
LEP LEP Madcam1 Madcam1 ROCK1 ROCK1 ADD2 ADD2 CHST4 CHST4 SELP SELP SELL SELL SELE SELE JAM2 JAM2 CX3CR1 CX3CR1 ITGB7 ITGB7 ITGA4 ITGA4 GOLPH3 GOLPH3 TNF TNF EXT1 EXT1 Vcam1 Vcam1 GCNT1 GCNT1 ITGB1 ITGB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Madcam1Mucosal vascular addressin cell adhesion molecule 1. (349 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
ADD2Adducin 2. (724 aa)
CHST4Sulfotransferase; Belongs to the sulfotransferase 1 family. (395 aa)
SELPSelectin P. (680 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (361 aa)
SELESelectin E. (495 aa)
JAM2Junctional adhesion molecule 2. (298 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (808 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
Vcam1Vascular cell adhesion molecule 1. (657 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (428 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.