(18 nodes) Detection of mechanical stimulus involved in sensory perception of pain network (Ictidomys tridecemlineatus)

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second shell of interactors

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Your Input:
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	CACNB3	Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1. (1044 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	GRM8	Glutamate metabotropic receptor 8. (908 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	CHRNA5	Cholinergic receptor nicotinic alpha 5 subunit. (468 aa)
	NTRK1	Tyrosine-protein kinase receptor. (799 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1183 aa)
	PAWR	Pro-apoptotic WT1 regulator. (340 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	SCN1A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1998 aa)
	TMEM120A	Transmembrane protein 120A. (342 aa)
	ASIC3	Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (533 aa)
	PHF24	PHD finger protein 24. (400 aa)
	KCNA1	Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (476 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNB3	SCN1A	ENSSTOP00000003774	ENSSTOP00000018059	Calcium voltage-gated channel auxiliary subunit beta 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.632
CXCL12	CXCR4	ENSSTOP00000005317	ENSSTOP00000005647	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.988
CXCL12	TLR4	ENSSTOP00000005317	ENSSTOP00000017653	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.464
CXCR4	CXCL12	ENSSTOP00000005647	ENSSTOP00000005317	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.988
FYN	GRIN2B	ENSSTOP00000006598	ENSSTOP00000000825	Tyrosine-protein kinase.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.824
FYN	ITGA2	ENSSTOP00000006598	ENSSTOP00000009514	Tyrosine-protein kinase.	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	0.435
FYN	NTRK1	ENSSTOP00000006598	ENSSTOP00000007027	Tyrosine-protein kinase.	Tyrosine-protein kinase receptor.	0.465
GRIN2B	FYN	ENSSTOP00000000825	ENSSTOP00000006598	Glutamate ionotropic receptor NMDA type subunit 2B.	Tyrosine-protein kinase.	0.824
GRIN2B	GRM8	ENSSTOP00000000825	ENSSTOP00000005797	Glutamate ionotropic receptor NMDA type subunit 2B.	Glutamate metabotropic receptor 8.	0.460
GRM8	GRIN2B	ENSSTOP00000005797	ENSSTOP00000000825	Glutamate metabotropic receptor 8.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.460
IL18	TLR4	ENSSTOP00000015111	ENSSTOP00000017653	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.599
ITGA2	FYN	ENSSTOP00000009514	ENSSTOP00000006598	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Tyrosine-protein kinase.	0.435
KCNA1	SCN1A	ENSSTOP00000031966	ENSSTOP00000018059	Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.457
NTRK1	FYN	ENSSTOP00000007027	ENSSTOP00000006598	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.465
SCN1A	CACNB3	ENSSTOP00000018059	ENSSTOP00000003774	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Calcium voltage-gated channel auxiliary subunit beta 3.	0.632
SCN1A	KCNA1	ENSSTOP00000018059	ENSSTOP00000031966	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family.	0.457
TLR4	CXCL12	ENSSTOP00000017653	ENSSTOP00000005317	Toll like receptor 4; Belongs to the Toll-like receptor family.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.464
TLR4	IL18	ENSSTOP00000017653	ENSSTOP00000015111	Toll like receptor 4; Belongs to the Toll-like receptor family.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.599