(57 nodes) Regulation of lipid catabolic process network (Ictidomys tridecemlineatus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	APOA5	Apolipoprotein A5. (370 aa)
	APOC3	Apolipoprotein C3. (130 aa)
	Hcar2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	APOH	Apolipoprotein H. (306 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (561 aa)
	ENSSTOP00000024190	Protein kinase domain-containing protein. (266 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (896 aa)
	ENSSTOP00000024432	MCD domain-containing protein. (267 aa)
	THRA	Thyroid hormone receptor alpha. (490 aa)
	SIRT6	Sirtuin 6. (351 aa)
	PNPLA2	Patatin like phospholipase domain containing 2. (489 aa)
	SCT	Secretin. (128 aa)
	CIDEA	Cell death inducing DFFA like effector a. (171 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	BSCL2	BSCL2 lipid droplet biogenesis associated, seipin. (462 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (413 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
	Cdk4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
	HCAR1	Hydroxycarboxylic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (340 aa)
	CRTC3	CREB regulated transcription coactivator 3. (575 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1071 aa)
	ABHD5	Abhydrolase domain containing 5. (349 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
	ALK	Tyrosine-protein kinase receptor. (1612 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
	SORL1	Sortilin related receptor 1. (2199 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	FABP1	Fatty acid binding protein 1. (127 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2328 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (529 aa)
	ANGPTL3	Angiopoietin like 3. (455 aa)
	Dbi	ACB domain-containing protein. (87 aa)
	SCTR	Secretin receptor; Belongs to the G-protein coupled receptor 2 family. (435 aa)
	DAGLB	Diacylglycerol lipase beta. (672 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1321 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (448 aa)
	APOA2	Apolipoprotein A2. (101 aa)
	ETFBKMT	Electron transfer flavoprotein subunit beta lysine methyltransferase. (262 aa)
	RARRES2	Retinoic acid receptor responder 2. (163 aa)
	LDLR	Low density lipoprotein receptor. (863 aa)
	ABCD1	ATP binding cassette subfamily D member 1. (739 aa)
	LONP2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa)
	LOC106144927	AIG1-type G domain-containing protein. (307 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (430 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	CNR1	Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (473 aa)
	Ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	LRRN4CL	LRRN4 C-terminal like. (237 aa)
	I3MWA1_ICTTR	Uncharacterized protein. (56 aa)
	TYSND1	Trypsin domain containing 1. (565 aa)
	PDE3B	Phosphodiesterase. (1046 aa)
	ENPP7	Ectonucleotide pyrophosphatase/phosphodiesterase 7. (427 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	CPT1A	Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
	ABCD2	ATP binding cassette subfamily D member 2. (741 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB11	ACACB	ENSSTOP00000006693	ENSSTOP00000004516	ATP binding cassette subfamily B member 11.	Acetyl-CoA carboxylase beta.	0.746
ABCB11	ENSSTOP00000024432	ENSSTOP00000006693	ENSSTOP00000024432	ATP binding cassette subfamily B member 11.	MCD domain-containing protein.	0.602
ABCD1	ABCD2	ENSSTOP00000007312	ENSSTOP00000011435	ATP binding cassette subfamily D member 1.	ATP binding cassette subfamily D member 2.	0.895
ABCD1	Dbi	ENSSTOP00000007312	ENSSTOP00000006039	ATP binding cassette subfamily D member 1.	ACB domain-containing protein.	0.503
ABCD2	ABCD1	ENSSTOP00000011435	ENSSTOP00000007312	ATP binding cassette subfamily D member 2.	ATP binding cassette subfamily D member 1.	0.895
ABCD2	Dbi	ENSSTOP00000011435	ENSSTOP00000006039	ATP binding cassette subfamily D member 2.	ACB domain-containing protein.	0.503
ABHD5	ACACB	ENSSTOP00000001853	ENSSTOP00000004516	Abhydrolase domain containing 5.	Acetyl-CoA carboxylase beta.	0.415
ABHD5	PLIN5	ENSSTOP00000001853	ENSSTOP00000021236	Abhydrolase domain containing 5.	Perilipin; Belongs to the perilipin family.	0.722
ABHD5	PNPLA2	ENSSTOP00000001853	ENSSTOP00000025960	Abhydrolase domain containing 5.	Patatin like phospholipase domain containing 2.	0.955
ACACB	ABCB11	ENSSTOP00000004516	ENSSTOP00000006693	Acetyl-CoA carboxylase beta.	ATP binding cassette subfamily B member 11.	0.746
ACACB	ABHD5	ENSSTOP00000004516	ENSSTOP00000001853	Acetyl-CoA carboxylase beta.	Abhydrolase domain containing 5.	0.415
ACACB	CPT1A	ENSSTOP00000004516	ENSSTOP00000011534	Acetyl-CoA carboxylase beta.	Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family.	0.924
ACACB	ENSSTOP00000024432	ENSSTOP00000004516	ENSSTOP00000024432	Acetyl-CoA carboxylase beta.	MCD domain-containing protein.	0.885
ACACB	PRKAA1	ENSSTOP00000004516	ENSSTOP00000024036	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.903
AKT1	AKT2	ENSSTOP00000028457	ENSSTOP00000002612	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.968
AKT1	CRTC3	ENSSTOP00000028457	ENSSTOP00000001259	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	CREB regulated transcription coactivator 3.	0.603
AKT1	Cdk4	ENSSTOP00000028457	ENSSTOP00000001018	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.420
AKT1	IL1B	ENSSTOP00000028457	ENSSTOP00000002047	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.519
AKT1	IRS1	ENSSTOP00000028457	ENSSTOP00000017790	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.607
AKT1	Ins	ENSSTOP00000028457	ENSSTOP00000017025	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.679