STRINGSTRING
RTF1 RTF1 MS4A2 MS4A2 LOC101972741 LOC101972741 ACP2 ACP2 FBXW9 FBXW9 PCIF1 PCIF1 DPYSL3 DPYSL3 SYK SYK PLCG2 PLCG2 CBL CBL PIN1 PIN1 APTX APTX Ywhae Ywhae HCK HCK SCAF4 SCAF4 DPYSL4 DPYSL4 Pkd2 Pkd2 YWHAB YWHAB PRKCSH PRKCSH PAFAH1B1 PAFAH1B1 GRAP2 GRAP2 TRPV1 TRPV1 Pik3r2 Pik3r2 PTPN5 PTPN5 RB1 RB1 NCK2 NCK2 MAPK3 MAPK3 RASA1 RASA1 THRAP3 THRAP3 Ubash3a Ubash3a I3LWF9_ICTTR I3LWF9_ICTTR SHC1 SHC1 SNCA SNCA MTOR MTOR SH3BP2 SH3BP2 CSNK1A1 CSNK1A1 PHF6 PHF6 PTPN6 PTPN6 LYN LYN Pik3r3 Pik3r3 SCAF8 SCAF8 EPB41 EPB41 UBASH3B UBASH3B MID2 MID2 MEN1 MEN1 SHF SHF MID1 MID1 PIK3R1 PIK3R1 ENSSTOP00000025973 ENSSTOP00000025973 NEDD4 NEDD4 CRK CRK STAP1 STAP1 PTPN3 PTPN3 ARRB1 ARRB1 CACNB2 CACNB2 Bbs1 Bbs1 FKBP4 FKBP4 ABL1 ABL1 NOS1 NOS1 SAMSN1 SAMSN1 CAV2 CAV2 PIH1D1 PIH1D1 LEO1 LEO1 VAV2 VAV2 LDLRAP1 LDLRAP1 Shb Shb CBX4 CBX4 BTRC BTRC GRAP GRAP SHD SHD ABL2 ABL2 PFN1 PFN1 PTPN11 PTPN11 FBXW7 FBXW7 FGR FGR SRC SRC PDE3B PDE3B GRB14 GRB14 SFN SFN MAPK1 MAPK1 Bcar3 Bcar3 DPYS DPYS GRB2 GRB2 LCK LCK CBLB CBLB PLCG1 PLCG1 Arr3 Arr3 I3MH84_ICTTR I3MH84_ICTTR SAG SAG CACNB1 CACNB1 TBL2 TBL2 ZAP70 ZAP70 SOCS3 SOCS3 VAV1 VAV1 PLAT PLAT URI1 URI1 TOX3 TOX3 SHE SHE IGF2R IGF2R SH2D3C SH2D3C CRMP1 CRMP1 CRKL CRKL TBK1 TBK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
MS4A2Membrane spanning 4-domains A2. (235 aa)
LOC101972741Uncharacterized protein. (363 aa)
ACP2Acid phosphatase 2, lysosomal; Belongs to the histidine acid phosphatase family. (422 aa)
FBXW9F-box and WD repeat domain containing 9. (462 aa)
PCIF1PDX1 C-terminal inhibiting factor 1. (706 aa)
DPYSL3Dihydropyrimidinase like 3. (684 aa)
SYKTyrosine-protein kinase. (626 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
CBLCbl proto-oncogene. (870 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
APTXAprataxin. (334 aa)
Ywhae14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
HCKTyrosine-protein kinase. (502 aa)
SCAF4SR-related CTD associated factor 4. (1064 aa)
DPYSL4Dihydropyrimidinase like 4. (572 aa)
Pkd2EF-hand domain-containing protein. (892 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
PRKCSHProtein kinase C substrate 80K-H. (533 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (411 aa)
GRAP2GRB2 related adaptor protein 2. (324 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (840 aa)
Pik3r2Uncharacterized protein. (724 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (538 aa)
RB1RB transcriptional corepressor 1. (957 aa)
NCK2Cytoplasmic protein. (380 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
RASA1RAS p21 protein activator 1. (1030 aa)
THRAP3Thyroid hormone receptor associated protein 3. (955 aa)
Ubash3aUncharacterized protein. (111 aa)
I3LWF9_ICTTRSH2 domain-containing protein. (118 aa)
SHC1SHC adaptor protein 1. (583 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
SH3BP2SH3 domain binding protein 2. (606 aa)
CSNK1A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (353 aa)
PHF6PHD finger protein 6. (365 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
LYNTyrosine-protein kinase. (512 aa)
Pik3r3Uncharacterized protein. (461 aa)
SCAF8SR-related CTD associated factor 8. (1268 aa)
EPB41Erythrocyte membrane protein band 4.1. (859 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
MID2Midline 2. (705 aa)
MEN1Menin 1. (616 aa)
SHFSrc homology 2 domain containing F. (321 aa)
MID1Midline 1. (667 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSSTOP0000002597314_3_3 domain-containing protein. (119 aa)
NEDD4E3 ubiquitin-protein ligase. (901 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
STAP1Signal transducing adaptor family member 1. (297 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (882 aa)
ARRB1Arrestin beta 1. (418 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (657 aa)
Bbs1BBS1 domain-containing protein. (594 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1329 aa)
SAMSN1SAM domain, SH3 domain and nuclear localization signals 1. (373 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PIH1D1PIH1 domain containing 1. (290 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
VAV2Vav guanine nucleotide exchange factor 2. (745 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
ShbSH2 domain-containing protein. (495 aa)
CBX4Chromobox 4. (555 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
GRAPUncharacterized protein. (157 aa)
SHDSrc homology 2 domain containing transforming protein D. (341 aa)
ABL2Tyrosine-protein kinase. (1142 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
FBXW7F-box and WD repeat domain containing 7. (713 aa)
FGRTyrosine-protein kinase. (527 aa)
SRCTyrosine-protein kinase. (541 aa)
PDE3BPhosphodiesterase. (1046 aa)
GRB14Growth factor receptor bound protein 14. (540 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
Bcar3Uncharacterized protein. (186 aa)
DPYSDihydropyrimidinase. (520 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LCKTyrosine-protein kinase. (521 aa)
CBLBCbl proto-oncogene B. (985 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
Arr3Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins (By similarity). (393 aa)
I3MH84_ICTTRUncharacterized protein. (334 aa)
SAGS-antigen visual arrestin. (401 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (643 aa)
TBL2Transducin beta like 2. (443 aa)
ZAP70Tyrosine-protein kinase. (608 aa)
SOCS3Suppressor of cytokine signaling 3. (227 aa)
VAV1Vav guanine nucleotide exchange factor 1. (822 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
URI1URI1 prefoldin like chaperone. (456 aa)
TOX3TOX high mobility group box family member 3. (580 aa)
SHESrc homology 2 domain containing E. (430 aa)
IGF2RInsulin like growth factor 2 receptor. (2452 aa)
SH2D3CSH2 domain containing 3C. (858 aa)
CRMP1Collapsin response mediator protein 1. (619 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
TBK1TANK binding kinase 1. (729 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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