(65 nodes) Cardiac muscle cell development network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AGTR2	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	MYOCD	Myocardin. (894 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	BMP10	Bone morphogenetic protein 10. (422 aa)
	SHOX2	Short stature homeobox 2. (319 aa)
	TCAP	Titin-cap. (167 aa)
	FHL2	Four and a half LIM domains 2. (279 aa)
	CSRP3	Cysteine and glycine rich protein 3. (194 aa)
	ADPRHL1	ADP-ribosylhydrolase like 1. (353 aa)
	ACTN2	Actinin alpha 2. (894 aa)
	I3M7N7_ICTTR	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (854 aa)
	NKX2-5	NK2 homeobox 5. (321 aa)
	SGCD	Sarcoglycan delta. (289 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	MYLK3	Myosin light chain kinase 3. (813 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	NRAP	Nebulin related anchoring protein. (1720 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (665 aa)
	Hnrnpu	B30.2/SPRY domain-containing protein. (411 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
	SORBS2	Sorbin and SH3 domain containing 2. (1300 aa)
	MYL2	Myosin light chain 2. (166 aa)
	LRRC10B	Leucine rich repeat containing 10B. (254 aa)
	Akap13	Uncharacterized protein. (1423 aa)
	ENSSTOP00000027973	Uncharacterized protein. (5517 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	PDLIM5	PDZ and LIM domain 5. (607 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (726 aa)
	MYH10	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
	TBX3	T-box transcription factor 3. (744 aa)
	MEF2A	Myocyte enhancer factor 2A. (496 aa)
	CXADR	Uncharacterized protein. (352 aa)
	Gata4	GATA-type domain-containing protein. (212 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	NKX2-6	NK2 homeobox 6. (282 aa)
	Pitx2	Homeobox protein. (325 aa)
	TBX18	T-box transcription factor 18. (614 aa)
	CAMK2D	Calcium/calmodulin dependent protein kinase II delta. (514 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	XIRP1	Xin actin binding repeat containing 1. (1132 aa)
	NEBL	Nebulette. (1014 aa)
	ACTC1	Actin alpha cardiac muscle 1. (377 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1380 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	FHOD3	Formin homology 2 domain containing 3. (1549 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (632 aa)
	ADRA1A	Adrenoceptor alpha 1A. (466 aa)
	ALPK3	Alpha kinase 3. (1652 aa)
	ALPK2	Alpha kinase 2. (2115 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (477 aa)
	MYH11	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	NEB	Nebulin. (7153 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	SRF	Serum response factor. (505 aa)
	LRRC10	Leucine rich repeat containing 10. (278 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1024 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	SPEG	Striated muscle enriched protein kinase. (3263 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTC1	ACTN2	ENSSTOP00000019133	ENSSTOP00000006587	Actin alpha cardiac muscle 1.	Actinin alpha 2.	0.686
ACTC1	CAV3	ENSSTOP00000019133	ENSSTOP00000011943	Actin alpha cardiac muscle 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.409
ACTC1	CSRP3	ENSSTOP00000019133	ENSSTOP00000007906	Actin alpha cardiac muscle 1.	Cysteine and glycine rich protein 3.	0.459
ACTC1	ENSSTOP00000027973	ENSSTOP00000019133	ENSSTOP00000027973	Actin alpha cardiac muscle 1.	Uncharacterized protein.	0.575
ACTC1	GSK3B	ENSSTOP00000019133	ENSSTOP00000023193	Actin alpha cardiac muscle 1.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.412
ACTC1	I3M7N7_ICTTR	ENSSTOP00000019133	ENSSTOP00000005645	Actin alpha cardiac muscle 1.	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.486
ACTC1	LMNA	ENSSTOP00000019133	ENSSTOP00000001565	Actin alpha cardiac muscle 1.	Lamin A/C; Belongs to the intermediate filament family.	0.422
ACTC1	MYH10	ENSSTOP00000019133	ENSSTOP00000025279	Actin alpha cardiac muscle 1.	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.790
ACTC1	MYH11	ENSSTOP00000019133	ENSSTOP00000014859	Actin alpha cardiac muscle 1.	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.824
ACTC1	MYL2	ENSSTOP00000019133	ENSSTOP00000030537	Actin alpha cardiac muscle 1.	Myosin light chain 2.	0.934
ACTN2	ACTC1	ENSSTOP00000006587	ENSSTOP00000019133	Actinin alpha 2.	Actin alpha cardiac muscle 1.	0.686
ACTN2	CAMK2D	ENSSTOP00000006587	ENSSTOP00000022466	Actinin alpha 2.	Calcium/calmodulin dependent protein kinase II delta.	0.799
ACTN2	CAV3	ENSSTOP00000006587	ENSSTOP00000011943	Actinin alpha 2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.444
ACTN2	CSRP3	ENSSTOP00000006587	ENSSTOP00000007906	Actinin alpha 2.	Cysteine and glycine rich protein 3.	0.803
ACTN2	ENSSTOP00000027973	ENSSTOP00000006587	ENSSTOP00000027973	Actinin alpha 2.	Uncharacterized protein.	0.927
ACTN2	I3M7N7_ICTTR	ENSSTOP00000006587	ENSSTOP00000005645	Actinin alpha 2.	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.596
ACTN2	LMNA	ENSSTOP00000006587	ENSSTOP00000001565	Actinin alpha 2.	Lamin A/C; Belongs to the intermediate filament family.	0.466
ACTN2	MYH10	ENSSTOP00000006587	ENSSTOP00000025279	Actinin alpha 2.	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.609
ACTN2	MYH11	ENSSTOP00000006587	ENSSTOP00000014859	Actinin alpha 2.	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.609
ACTN2	MYL2	ENSSTOP00000006587	ENSSTOP00000030537	Actinin alpha 2.	Myosin light chain 2.	0.724