(21 nodes) Pericardium development network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP7	Bone morphogenetic protein 7. (431 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
	WT1	WT1 transcription factor. (523 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2525 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	HEG1	Heart development protein with EGF like domains 1. (1314 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	RPGRIP1L	RPGRIP1 like. (1299 aa)
	NKX2-6	NK2 homeobox 6. (282 aa)
	Pdpn	Uncharacterized protein. (163 aa)
	MECOM	MDS1 and EVI1 complex locus. (1051 aa)
	CCM2	CCM2 scaffold protein. (453 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
	TBX20	T-box transcription factor 20. (446 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	FLRT3	Fibronectin leucine rich transmembrane protein 3. (649 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP5	ENSSTOP00000018746	ENSSTOP00000002171	Bone morphogenetic protein 2.	Bone morphogenetic protein 5.	0.788
BMP2	BMP7	ENSSTOP00000018746	ENSSTOP00000011380	Bone morphogenetic protein 2.	Bone morphogenetic protein 7.	0.893
BMP2	SMAD2	ENSSTOP00000018746	ENSSTOP00000003397	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.706
BMP2	SMAD3	ENSSTOP00000018746	ENSSTOP00000009229	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.697
BMP5	BMP2	ENSSTOP00000002171	ENSSTOP00000018746	Bone morphogenetic protein 5.	Bone morphogenetic protein 2.	0.788
BMP5	SMAD2	ENSSTOP00000002171	ENSSTOP00000003397	Bone morphogenetic protein 5.	Mothers against decapentaplegic homolog.	0.403
BMP5	SMAD3	ENSSTOP00000002171	ENSSTOP00000009229	Bone morphogenetic protein 5.	Mothers against decapentaplegic homolog.	0.403
BMP5	WT1	ENSSTOP00000002171	ENSSTOP00000016765	Bone morphogenetic protein 5.	WT1 transcription factor.	0.407
BMP7	BMP2	ENSSTOP00000011380	ENSSTOP00000018746	Bone morphogenetic protein 7.	Bone morphogenetic protein 2.	0.893
BMP7	SMAD2	ENSSTOP00000011380	ENSSTOP00000003397	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.591
BMP7	SMAD3	ENSSTOP00000011380	ENSSTOP00000009229	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.558
BMP7	WT1	ENSSTOP00000011380	ENSSTOP00000016765	Bone morphogenetic protein 7.	WT1 transcription factor.	0.407
CCM2	HEG1	ENSSTOP00000025493	ENSSTOP00000020592	CCM2 scaffold protein.	Heart development protein with EGF like domains 1.	0.617
CCM2	SETD2	ENSSTOP00000025493	ENSSTOP00000016952	CCM2 scaffold protein.	SET domain containing 2, histone lysine methyltransferase.	0.500
HAND2	TBX20	ENSSTOP00000020619	ENSSTOP00000026130	Heart and neural crest derivatives expressed 2.	T-box transcription factor 20.	0.612
HAND2	TBX5	ENSSTOP00000020619	ENSSTOP00000002875	Heart and neural crest derivatives expressed 2.	T-box transcription factor 5.	0.636
HEG1	CCM2	ENSSTOP00000020592	ENSSTOP00000025493	Heart development protein with EGF like domains 1.	CCM2 scaffold protein.	0.617
LRP6	WNT5A	ENSSTOP00000013745	ENSSTOP00000020681	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.925
MECOM	SMAD2	ENSSTOP00000031742	ENSSTOP00000003397	MDS1 and EVI1 complex locus.	Mothers against decapentaplegic homolog.	0.454
MECOM	SMAD3	ENSSTOP00000031742	ENSSTOP00000009229	MDS1 and EVI1 complex locus.	Mothers against decapentaplegic homolog.	0.551