STRINGSTRING
PTPN11 PTPN11 RARG RARG WNT5A WNT5A HOXB3 HOXB3 Ankrd11 Ankrd11 Zfand5 Zfand5 DKK1 DKK1 MKKS MKKS SRF SRF ALDH1A2 ALDH1A2 EP300 EP300 MAPK3 MAPK3 TGFB2 TGFB2 GRHL2 GRHL2 RRAS RRAS SGPL1 SGPL1 Map2k2 Map2k2 LEF1 LEF1 RAB3GAP1 RAB3GAP1 TCF7L2 TCF7L2 STRA6 STRA6 SKI SKI ASPH ASPH CRISPLD2 CRISPLD2 BBS4 BBS4 ENSSTOP00000027310 ENSSTOP00000027310 TFAP2A TFAP2A RARA RARA COL1A1 COL1A1 ENSSTOP00000024247 ENSSTOP00000024247 CSRNP1 CSRNP1 TGFB3 TGFB3 KAT6A KAT6A EDNRA EDNRA CHD7 CHD7 PDGFRA PDGFRA Plekha1 Plekha1 TGFB1 TGFB1 ITGA4 ITGA4 MAP2K1 MAP2K1 ALDH1A3 ALDH1A3 LOC101971898 LOC101971898 LOC101961235 LOC101961235 DLX5 DLX5 CREBBP CREBBP TBX1 TBX1 BRAF BRAF MAPK1 MAPK1 NIPBL NIPBL LRP6 LRP6 PAX9 PAX9 ARID5B ARID5B MMP2 MMP2 ANKRD12 ANKRD12 TIPARP TIPARP ZIC3 ZIC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
RARGRetinoic acid receptor gamma. (458 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
HOXB3Homeobox B3. (434 aa)
Ankrd11Ankyrin repeat domain 11. (2264 aa)
Zfand5Uncharacterized protein. (172 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
SRFSerum response factor. (505 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
EP300E1A binding protein p300. (2423 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GRHL2Grainyhead like transcription factor 2. (607 aa)
RRASRAS related. (218 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (987 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
STRA6Stimulated by retinoic acid 6. (662 aa)
SKISKI proto-oncogene. (730 aa)
ASPHAspartate beta-hydroxylase. (770 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (548 aa)
BBS4Bardet-Biedl syndrome 4. (514 aa)
ENSSTOP00000027310ANK_REP_REGION domain-containing protein. (329 aa)
TFAP2ATranscription factor AP-2 alpha. (477 aa)
RARARetinoic acid receptor alpha. (462 aa)
COL1A1Collagen type I alpha 1 chain. (1268 aa)
ENSSTOP00000024247Uncharacterized protein. (327 aa)
CSRNP1Cysteine and serine rich nuclear protein 1. (581 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2017 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
Plekha1Uncharacterized protein. (343 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (520 aa)
LOC101971898Uncharacterized protein. (414 aa)
LOC101961235Uncharacterized protein. (214 aa)
DLX5Distal-less homeobox 5. (289 aa)
CREBBPCREB binding protein. (2410 aa)
TBX1T-box transcription factor 1. (406 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
NIPBLNipped-B protein. (2803 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
PAX9Paired box 9. (342 aa)
ARID5BAT-rich interaction domain 5B. (1195 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
ANKRD12Ankyrin repeat domain 12. (2050 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (681 aa)
ZIC3Zic family member 3. (466 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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