STRINGSTRING
JADE2 JADE2 EIF2AK4 EIF2AK4 MED12 MED12 NLGN3 NLGN3 EPB41L5 EPB41L5 CTNNB1 CTNNB1 SEMA3F SEMA3F Flrt1 Flrt1 TNN TNN SLIT1 SLIT1 C9orf72 C9orf72 SEMA5B SEMA5B TGFB1 TGFB1 ITGA4 ITGA4 HSP90AA1 HSP90AA1 BDNF BDNF TBX2 TBX2 FLRT3 FLRT3 AREG AREG ADPRHL1 ADPRHL1 CDKL3 CDKL3 BCAN BCAN Wasf1 Wasf1 EFNA5 EFNA5 RDH10 RDH10 TMTC3 TMTC3 HOXD13 HOXD13 FGFR2 FGFR2 PLXNA3 PLXNA3 I3M249_ICTTR I3M249_ICTTR SHH SHH IMPACT IMPACT PLXNA1 PLXNA1 POU4F3 POU4F3 SLC9A6 SLC9A6 NDN NDN SFRP1 SFRP1 I3MW25_ICTTR I3MW25_ICTTR Spry2 Spry2 RNF6 RNF6 CSF1R CSF1R SEMA7A SEMA7A LHX1 LHX1 NRN1L NRN1L TRIM28 TRIM28 MED1 MED1 I3N055_ICTTR I3N055_ICTTR DCX DCX CDH4 CDH4 FGF10 FGF10 Ndel1 Ndel1 MAPT MAPT TNC TNC CADM1 CADM1 NIN NIN RARG RARG CSF1 CSF1 MESP1 MESP1 SPRY1 SPRY1 WNT5A WNT5A WNT11 WNT11 SOX9 SOX9 EDNRA EDNRA POU4F2 POU4F2 WNT3A WNT3A FGF1 FGF1 HSP90AB1 HSP90AB1 TMEM108 TMEM108 SALL1 SALL1 EMX1 EMX1 LOC101975245 LOC101975245 CYFIP1 CYFIP1 ULK2 ULK2 DCLK1 DCLK1 TGFBR2 TGFBR2 LOC101974646 LOC101974646 BIN3 BIN3 SIRT6 SIRT6 LOC101965498 LOC101965498 ENSSTOP00000026345 ENSSTOP00000026345 KIF26B KIF26B ALCAM ALCAM APP APP CPNE1 CPNE1 DDR1 DDR1 RND2 RND2 POSTN POSTN IQGAP1 IQGAP1 ZEB2 ZEB2 TNR TNR VCL VCL RAPH1 RAPH1 NRP2 NRP2 CYFIP2 CYFIP2 PTHLH PTHLH PAK6 PAK6 ENSSTOP00000031279 ENSSTOP00000031279 Nrn1 Nrn1 LLPH LLPH ENSSTOP00000031635 ENSSTOP00000031635 ENSSTOP00000032175 ENSSTOP00000032175 TFAP2C TFAP2C SLIT2 SLIT2 SMO SMO ULK1 ULK1 SLC12A2 SLC12A2 Ahr Ahr STK11 STK11 SEMA5A SEMA5A VANGL2 VANGL2 KDM1A KDM1A LOC101973790 LOC101973790 SFRP2 SFRP2 I3M023_ICTTR I3M023_ICTTR PTK7 PTK7 SRF SRF EDN2 EDN2 LZTS2 LZTS2 LRP6 LRP6 EXT1 EXT1 MAP1B MAP1B LAMB2 LAMB2 SPAG6 SPAG6 BMP4 BMP4 IST1 IST1 USP9X USP9X LHX2 LHX2 EDN1 EDN1 ROBO1 ROBO1 KDM5B KDM5B RYK RYK HDAC6 HDAC6 SLIT3 SLIT3 MST1 MST1 NRP1 NRP1 ITGB1 ITGB1 DVL1 DVL1 LIMK1 LIMK1 EDN3 EDN3 ST8SIA2 ST8SIA2 HNF1B HNF1B SFRP5 SFRP5 Aurka Aurka
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JADE2Jade family PHD finger 2. (830 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1631 aa)
MED12Mediator complex subunit 12. (2146 aa)
NLGN3Neuroligin 3. (848 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (732 aa)
CTNNB1Catenin beta 1. (781 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
Flrt1Fibronectin leucine rich transmembrane protein 1. (674 aa)
TNNTenascin N. (1561 aa)
SLIT1Slit guidance ligand 1. (1525 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
SEMA5BSemaphorin 5B. (1093 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (285 aa)
TBX2T-box transcription factor 2. (712 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
AREGAmphiregulin. (252 aa)
ADPRHL1ADP-ribosylhydrolase like 1. (353 aa)
CDKL3Cyclin dependent kinase like 3. (592 aa)
BCANBrevican. (886 aa)
Wasf1WH2 domain-containing protein. (559 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (186 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
TMTC3Transmembrane O-mannosyltransferase targeting cadherins 3. (917 aa)
HOXD13Homeobox D13. (327 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
PLXNA3Plexin A3. (1872 aa)
I3M249_ICTTRUncharacterized protein. (683 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
IMPACTImpact RWD domain protein. (297 aa)
PLXNA1Plexin A1. (1878 aa)
POU4F3POU domain protein. (338 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (677 aa)
NDNNecdin, MAGE family member. (325 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
I3MW25_ICTTRUncharacterized protein. (144 aa)
Spry2Uncharacterized protein. (315 aa)
RNF6Ring finger protein 6. (683 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
LHX1LIM homeobox 1. (406 aa)
NRN1LNeuritin 1 like. (160 aa)
TRIM28Tripartite motif containing 28. (835 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
I3N055_ICTTRCobl domain-containing protein. (335 aa)
DCXDoublecortin. (360 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (864 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
Ndel1NUDE_C domain-containing protein. (345 aa)
MAPTMicrotubule-associated protein. (430 aa)
TNCTenascin C. (2171 aa)
CADM1Cell adhesion molecule 1. (477 aa)
NINNinein. (2136 aa)
RARGRetinoic acid receptor gamma. (458 aa)
CSF1Colony stimulating factor 1. (497 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (246 aa)
SPRY1Sprouty RTK signaling antagonist 1. (315 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOX9SRY-box transcription factor 9. (509 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
POU4F2POU domain protein. (410 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
TMEM108Transmembrane protein 108. (574 aa)
SALL1Spalt like transcription factor 1. (1313 aa)
EMX1Empty spiracles homeobox 1. (257 aa)
LOC101975245HATPase_c domain-containing protein. (733 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1058 aa)
DCLK1Doublecortin like kinase 1. (761 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC101974646NUDE_C domain-containing protein. (376 aa)
BIN3Bridging integrator 3. (253 aa)
SIRT6Sirtuin 6. (351 aa)
LOC101965498Uncharacterized protein. (325 aa)
ENSSTOP00000026345Protein kinase domain-containing protein. (386 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1835 aa)
ALCAMActivated leukocyte cell adhesion molecule. (583 aa)
APPAmyloid beta precursor protein. (739 aa)
CPNE1Copine 1. (537 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (915 aa)
RND2Rho family GTPase 2. (219 aa)
POSTNPeriostin. (836 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1249 aa)
TNRTenascin R. (1358 aa)
VCLVinculin. (1134 aa)
RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1331 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
PTHLHParathyroid hormone like hormone. (177 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
ENSSTOP00000031279Uncharacterized protein. (117 aa)
Nrn1Uncharacterized protein. (176 aa)
LLPHLLP homolog, long-term synaptic facilitation factor. (127 aa)
ENSSTOP00000031635Uncharacterized protein. (493 aa)
ENSSTOP00000032175Uncharacterized protein. (123 aa)
TFAP2CTranscription factor AP-2 gamma. (419 aa)
SLIT2Slit guidance ligand 2. (1559 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1041 aa)
SLC12A2Solute carrier family 12 member 2. (1108 aa)
AhrUncharacterized protein. (848 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
SEMA5ASemaphorin 5A. (1074 aa)
VANGL2Vang-like protein. (547 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (755 aa)
LOC101973790Uncharacterized protein. (311 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
I3M023_ICTTRUncharacterized protein. (778 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1063 aa)
SRFSerum response factor. (505 aa)
EDN2Endothelin 2. (148 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (677 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
MAP1BMicrotubule associated protein 1B. (2469 aa)
LAMB2Laminin subunit beta 2. (1846 aa)
SPAG6Sperm associated antigen 6. (509 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
IST1IST1 factor associated with ESCRT-III. (367 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
LHX2LIM homeobox 2. (406 aa)
EDN1Endothelin 1. (202 aa)
ROBO1Roundabout guidance receptor 1. (1587 aa)
KDM5BLysine demethylase 5B. (1544 aa)
RYKReceptor like tyrosine kinase. (475 aa)
HDAC6Histone deacetylase 6. (1142 aa)
SLIT3Slit guidance ligand 3. (1385 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (715 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
DVL1Dishevelled segment polarity protein 1. (696 aa)
LIMK1LIM domain kinase 1. (628 aa)
EDN3Endothelin 3. (197 aa)
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (342 aa)
HNF1BHNF1 homeobox B. (558 aa)
SFRP5Secreted frizzled related protein 5. (316 aa)
AurkaProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (363 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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