(23 nodes) Morphogenesis of an epithelial fold network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LUZP1	Leucine zipper protein 1. (1073 aa)
	EGFR	Receptor protein-tyrosine kinase. (1192 aa)
	HHEX	Hematopoietically expressed homeobox. (272 aa)
	CECR2	CECR2 histone acetyl-lysine reader. (1414 aa)
	Hif1a	Uncharacterized protein. (821 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	GLI2	GLI family zinc finger 2. (1540 aa)
	HOXD13	Homeobox D13. (327 aa)
	FGFR2	Fibroblast growth factor receptor. (823 aa)
	SOSTDC1	Sclerostin domain containing 1. (206 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	OVOL2	Ovo like zinc finger 2. (276 aa)
	GDF7	Growth differentiation factor 7. (445 aa)
	I3N6Q6_ICTTR	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (160 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	AR	Androgen receptor. (884 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	NODAL	Nodal growth differentiation factor. (350 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	GATAD2A	GATA zinc finger domain containing 2A. (653 aa)
	Cfl1	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (203 aa)
	PTHLH	Parathyroid hormone like hormone. (177 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	EGFR	ENSSTOP00000015265	ENSSTOP00000006038	Androgen receptor.	Receptor protein-tyrosine kinase.	0.708
AR	FGF10	ENSSTOP00000015265	ENSSTOP00000017863	Androgen receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.458
AR	Hif1a	ENSSTOP00000015265	ENSSTOP00000004344	Androgen receptor.	Uncharacterized protein.	0.543
BMP4	BMP5	ENSSTOP00000001023	ENSSTOP00000002171	Bone morphogenetic protein 4.	Bone morphogenetic protein 5.	0.788
BMP4	BMP7	ENSSTOP00000001023	ENSSTOP00000011380	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.902
BMP4	FGF10	ENSSTOP00000001023	ENSSTOP00000017863	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
BMP4	FGFR2	ENSSTOP00000001023	ENSSTOP00000003568	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.408
BMP5	BMP4	ENSSTOP00000002171	ENSSTOP00000001023	Bone morphogenetic protein 5.	Bone morphogenetic protein 4.	0.788
BMP5	GDF7	ENSSTOP00000002171	ENSSTOP00000018759	Bone morphogenetic protein 5.	Growth differentiation factor 7.	0.879
BMP7	BMP4	ENSSTOP00000011380	ENSSTOP00000001023	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.902
BMP7	GDF7	ENSSTOP00000011380	ENSSTOP00000018759	Bone morphogenetic protein 7.	Growth differentiation factor 7.	0.918
BMP7	HOXD13	ENSSTOP00000011380	ENSSTOP00000003689	Bone morphogenetic protein 7.	Homeobox D13.	0.412
CECR2	TP63	ENSSTOP00000005302	ENSSTOP00000012357	CECR2 histone acetyl-lysine reader.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.405
EGFR	AR	ENSSTOP00000006038	ENSSTOP00000015265	Receptor protein-tyrosine kinase.	Androgen receptor.	0.708
EGFR	FGF10	ENSSTOP00000006038	ENSSTOP00000017863	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.902
EGFR	FGFR2	ENSSTOP00000006038	ENSSTOP00000003568	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.859
EGFR	Hif1a	ENSSTOP00000006038	ENSSTOP00000004344	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.757
EGFR	RDH10	ENSSTOP00000006038	ENSSTOP00000004131	Receptor protein-tyrosine kinase.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.412
FGF10	AR	ENSSTOP00000017863	ENSSTOP00000015265	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Androgen receptor.	0.458
FGF10	BMP4	ENSSTOP00000017863	ENSSTOP00000001023	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.502