(14 nodes) Branching involved in labyrinthine layer morphogenesis network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RSPO3	R-spondin 3. (275 aa)
	LOC101977702	GCM domain-containing protein. (436 aa)
	Gcm1	GCM domain-containing protein. (382 aa)
	SPINT2	Serine peptidase inhibitor, Kunitz type 2. (252 aa)
	GRHL2	Grainyhead like transcription factor 2. (607 aa)
	FGFR2	Fibroblast growth factor receptor. (823 aa)
	IL10	Interleukin 10. (178 aa)
	ST14	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
	SPINT1	Serine peptidase inhibitor, Kunitz type 1. (510 aa)
	SOCS3	Suppressor of cytokine signaling 3. (227 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	LLGL2	LLGL scribble cell polarity complex component 2. (1024 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (128 aa)
	ADM	Adrenomedullin. (188 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGFR2	GRB2	ENSSTOP00000003568	ENSSTOP00000011345	Fibroblast growth factor receptor.	Growth factor receptor bound protein 2.	0.955
GRB2	FGFR2	ENSSTOP00000011345	ENSSTOP00000003568	Growth factor receptor bound protein 2.	Fibroblast growth factor receptor.	0.955
IL10	SOCS3	ENSSTOP00000005716	ENSSTOP00000009768	Interleukin 10.	Suppressor of cytokine signaling 3.	0.574
SOCS3	IL10	ENSSTOP00000009768	ENSSTOP00000005716	Suppressor of cytokine signaling 3.	Interleukin 10.	0.574
SPINT1	ST14	ENSSTOP00000000327	ENSSTOP00000009037	Serine peptidase inhibitor, Kunitz type 1.	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	0.987
SPINT2	ST14	ENSSTOP00000012934	ENSSTOP00000009037	Serine peptidase inhibitor, Kunitz type 2.	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	0.709
ST14	SPINT1	ENSSTOP00000009037	ENSSTOP00000000327	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	Serine peptidase inhibitor, Kunitz type 1.	0.987
ST14	SPINT2	ENSSTOP00000009037	ENSSTOP00000012934	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.	Serine peptidase inhibitor, Kunitz type 2.	0.709