(57 nodes) Ureteric bud morphogenesis network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TMEM59L	Transmembrane protein 59 like. (345 aa)
	Hs2st1	Uncharacterized protein. (356 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
	GATA3	GATA binding protein 3. (444 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (320 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	Pkd2	EF-hand domain-containing protein. (892 aa)
	ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif 16. (1218 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	GZF1	GDNF inducible zinc finger protein 1. (713 aa)
	HS3ST3B1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
	FAT4	FAT atypical cadherin 4. (4978 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
	PAX2	Paired box 2. (417 aa)
	ILK	Integrin linked kinase. (452 aa)
	HNF1B	HNF1 homeobox B. (558 aa)
	TIMELESS	Timeless circadian regulator. (1147 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (677 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SHH	Sonic hedgehog signaling molecule. (370 aa)
	GREB1	Uncharacterized protein. (1955 aa)
	Fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
	HOXA11	Homeobox A11. (315 aa)
	HS3ST3A1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (348 aa)
	BCL2	BCL2 apoptosis regulator. (195 aa)
	LAMA5	Laminin subunit alpha 5. (3474 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (477 aa)
	WT1	WT1 transcription factor. (523 aa)
	PSPN	Persephin. (158 aa)
	LHX1	LIM homeobox 1. (406 aa)
	SIX1	SIX homeobox 1. (284 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	GDNF	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (212 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	GREM1	Gremlin. (184 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1916 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
	SALL1	Spalt like transcription factor 1. (1313 aa)
	GLI3	GLI family zinc finger 3. (1582 aa)
	TCF21	Transcription factor 21. (179 aa)
	DSPP	Dentin sialophosphoprotein. (1075 aa)
	DCHS1	Dachsous cadherin-related 1. (3293 aa)
	PBX1	PBX homeobox 1. (430 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1835 aa)
	PAX8	Paired box 8. (574 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	NPNT	Nephronectin. (612 aa)
	PTCH1	Patched 1. (1450 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CTNNB1	ENSSTOP00000016154	ENSSTOP00000014441	BCL2 apoptosis regulator.	Catenin beta 1.	0.523
BMP2	BMP4	ENSSTOP00000018746	ENSSTOP00000001023	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.887
BMP2	CTNNB1	ENSSTOP00000018746	ENSSTOP00000014441	Bone morphogenetic protein 2.	Catenin beta 1.	0.455
BMP2	FGF8	ENSSTOP00000018746	ENSSTOP00000027210	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.447
BMP2	Fgf2	ENSSTOP00000018746	ENSSTOP00000015653	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.580
BMP2	GPC3	ENSSTOP00000018746	ENSSTOP00000009043	Bone morphogenetic protein 2.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.502
BMP2	GREM1	ENSSTOP00000018746	ENSSTOP00000022065	Bone morphogenetic protein 2.	Gremlin.	0.938
BMP2	PTCH1	ENSSTOP00000018746	ENSSTOP00000031262	Bone morphogenetic protein 2.	Patched 1.	0.537
BMP2	SHH	ENSSTOP00000018746	ENSSTOP00000015201	Bone morphogenetic protein 2.	Sonic hedgehog signaling molecule.	0.521
BMP2	SMAD4	ENSSTOP00000018746	ENSSTOP00000016654	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.910
BMP4	BMP2	ENSSTOP00000001023	ENSSTOP00000018746	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.887
BMP4	CTNNB1	ENSSTOP00000001023	ENSSTOP00000014441	Bone morphogenetic protein 4.	Catenin beta 1.	0.458
BMP4	FGF8	ENSSTOP00000001023	ENSSTOP00000027210	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.573
BMP4	Fgf2	ENSSTOP00000001023	ENSSTOP00000015653	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.475
BMP4	GPC3	ENSSTOP00000001023	ENSSTOP00000009043	Bone morphogenetic protein 4.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.502
BMP4	GREM1	ENSSTOP00000001023	ENSSTOP00000022065	Bone morphogenetic protein 4.	Gremlin.	0.928
BMP4	PTCH1	ENSSTOP00000001023	ENSSTOP00000031262	Bone morphogenetic protein 4.	Patched 1.	0.537
BMP4	SHH	ENSSTOP00000001023	ENSSTOP00000015201	Bone morphogenetic protein 4.	Sonic hedgehog signaling molecule.	0.691
BMP4	SMAD4	ENSSTOP00000001023	ENSSTOP00000016654	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.921
CTNNB1	BCL2	ENSSTOP00000014441	ENSSTOP00000016154	Catenin beta 1.	BCL2 apoptosis regulator.	0.523