STRINGSTRING
HEY1 HEY1 MYLK MYLK NDST1 NDST1 ACVRL1 ACVRL1 ROBO1 ROBO1 EDN1 EDN1 SMAD6 SMAD6 ADAMTS9 ADAMTS9 BMP4 BMP4 ADAMTS6 ADAMTS6 TGFB2 TGFB2 AP2B1 AP2B1 TAB1 TAB1 BMPR2 BMPR2 ADGRF4 ADGRF4 DLL4 DLL4 NOTCH3 NOTCH3 Pkd2 Pkd2 EGR2 EGR2 TBX1 TBX1 ANGPTL3 ANGPTL3 EYA1 EYA1 CXCR4 CXCR4 LDLR LDLR ENG ENG CHRD CHRD CITED2 CITED2 ARID2 ARID2 TBX2 TBX2 ADGRF5 ADGRF5 FOXH1 FOXH1 SNX17 SNX17 LTBP1 LTBP1 MYOCD MYOCD CHD7 CHD7 CNTRL CNTRL LRP1 LRP1 NRP1 NRP1 TGFBR1 TGFBR1 LOXL1 LOXL1 SRF SRF ACVR2B ACVR2B SLC2A10 SLC2A10 ZMIZ1 ZMIZ1 BMPR1A BMPR1A LOX LOX PRDM1 PRDM1 LEP LEP TFAP2B TFAP2B SHH SHH SMAD7 SMAD7 Ddit3 Ddit3 FOXC2 FOXC2 HECTD1 HECTD1 SEC24B SEC24B KIF7 KIF7 SIX1 SIX1 HEY2 HEY2 DNM2 DNM2 PTGER4 PTGER4 HES1 HES1 HAND2 HAND2 APOB APOB WNT11 WNT11 EDNRA EDNRA KAT6A KAT6A HOXA1 HOXA1 PLXND1 PLXND1 PRRX1 PRRX1 APLNR APLNR SUFU SUFU HPGD HPGD GLI3 GLI3 HOXA13 HOXA13 PDGFRB PDGFRB COMP COMP LUZP1 LUZP1 SMARCA4 SMARCA4 EFEMP2 EFEMP2 MYH10 MYH10 DCTN5 DCTN5 NKX3-1 NKX3-1 FOLR1 FOLR1 RBPJ RBPJ PDE2A PDE2A JAG1 JAG1 PRICKLE1 PRICKLE1 NF1 NF1 FGF8 FGF8 PROX1 PROX1 NPRL3 NPRL3 LRP2 LRP2 ENSSTOP00000030319 ENSSTOP00000030319 COL3A1 COL3A1 ROBO2 ROBO2 FKBP10 FKBP10 FUZ FUZ STRA6 STRA6 ENSSTOP00000032126 ENSSTOP00000032126
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
MYLKMyosin light chain kinase. (1897 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ROBO1Roundabout guidance receptor 1. (1587 aa)
EDN1Endothelin 1. (202 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1864 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1118 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AP2B1AP complex subunit beta. (951 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ADGRF4Adhesion G protein-coupled receptor F4; Belongs to the G-protein coupled receptor 2 family. (662 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
NOTCH3Notch receptor 3. (2277 aa)
Pkd2EF-hand domain-containing protein. (892 aa)
EGR2Early growth response 2. (423 aa)
TBX1T-box transcription factor 1. (406 aa)
ANGPTL3Angiopoietin like 3. (455 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
LDLRLow density lipoprotein receptor. (863 aa)
ENGEndoglin. (463 aa)
CHRDChordin. (898 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (274 aa)
ARID2AT-rich interaction domain 2. (1768 aa)
TBX2T-box transcription factor 2. (712 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1382 aa)
FOXH1Forkhead box H1. (370 aa)
SNX17Sorting nexin 17. (470 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1488 aa)
MYOCDMyocardin. (894 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
CNTRLCentriolin. (2341 aa)
LRP1LDL receptor related protein 1. (4508 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
LOXL1Lysyl oxidase like 1. (595 aa)
SRFSerum response factor. (505 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (548 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1068 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOXLysyl oxidase. (397 aa)
PRDM1PR/SET domain 1. (821 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
Ddit3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
FOXC2Forkhead box C2. (500 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1219 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1345 aa)
SIX1SIX homeobox 1. (284 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (488 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
APOBApolipoprotein B. (4482 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2017 aa)
HOXA1Homeobox A1. (337 aa)
PLXND1Plexin D1. (1796 aa)
PRRX1Paired related homeobox 1. (245 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (488 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
GLI3GLI family zinc finger 3. (1582 aa)
HOXA13Homeobox A13. (216 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
LUZP1Leucine zipper protein 1. (1073 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1646 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
DCTN5Dynactin subunit 5. (182 aa)
NKX3-1NK3 homeobox 1. (144 aa)
FOLR1Folate receptor alpha. (255 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (522 aa)
PDE2APhosphodiesterase. (941 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PRICKLE1Prickle planar cell polarity protein 1. (833 aa)
NF1Neurofibromin 1. (2473 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PROX1Prospero homeobox 1. (737 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
LRP2LDL receptor related protein 2. (4656 aa)
ENSSTOP00000030319Uncharacterized protein. (2101 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
ROBO2Roundabout guidance receptor 2. (1468 aa)
FKBP10Peptidylprolyl isomerase. (583 aa)
FUZFuzzy planar cell polarity protein. (358 aa)
STRA6Stimulated by retinoic acid 6. (662 aa)
ENSSTOP00000032126Uncharacterized protein. (141 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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