STRINGSTRING
BMP6 BMP6 WNT4 WNT4 INSR INSR PLCD1 PLCD1 ZBTB20 ZBTB20 GUCA2A GUCA2A PLA2G3 PLA2G3 IL1B IL1B APOA1 APOA1 CLYBL CLYBL STK11 STK11 GCK GCK HTR2A HTR2A AKT2 AKT2 PTH1R PTH1R ADORA2B ADORA2B Fdps Fdps RDH10 RDH10 FABP1 FABP1 NR4A3 NR4A3 HNF1A HNF1A Hif1a Hif1a GCG GCG C1QTNF2 C1QTNF2 NR1D1 NR1D1 CYP7A1 CYP7A1 STAT3 STAT3 STAR STAR SLC45A3 SLC45A3 PTPN2 PTPN2 DDB1 DDB1 SLC25A12 SLC25A12 DYRK2 DYRK2 Ndufc2 Ndufc2 ABCD1 ABCD1 CD74 CD74 MAP2K1 MAP2K1 Ptgs2 Ptgs2 Foxo1 Foxo1 ACTN3 ACTN3 P2RX7 P2RX7 GPT GPT TREM2 TREM2 PRKAA2 PRKAA2 GUCA1C GUCA1C PPARA PPARA POU1F1 POU1F1 LOC101971868 LOC101971868 NR1H4 NR1H4 DGAT2 DGAT2 PRKCE PRKCE ABCD2 ABCD2 PPARG PPARG PID1 PID1 CPT1A CPT1A TNF TNF Srebf2 Srebf2 ADCYAP1R1 ADCYAP1R1 RGN RGN ABCG4 ABCG4 Elovl5 Elovl5 VCP VCP GHSR GHSR ADIPOQ ADIPOQ PPP1R3D PPP1R3D LOC101973014 LOC101973014 SIRT1 SIRT1 AVPR1A AVPR1A LOC101956324 LOC101956324 EPM2AIP1 EPM2AIP1 PPP1R3G PPP1R3G I3MWA1_ICTTR I3MWA1_ICTTR ABCG1 ABCG1 P2RY6 P2RY6 BEND3 BEND3 AGT AGT Ins Ins SCP2 SCP2 APOA5 APOA5 AVPR1B AVPR1B I3MZU0_ICTTR I3MZU0_ICTTR PRXL2C PRXL2C IRS1 IRS1 MLXIPL MLXIPL IGF2 IGF2 COMT COMT SEC14L2 SEC14L2 I3N5A9_ICTTR I3N5A9_ICTTR MID1IP1 MID1IP1 Guca1a Guca1a GUCA2B GUCA2B PTH PTH P2RY1 P2RY1 PPP4R3A PPP4R3A I3N998_ICTTR I3N998_ICTTR ANXA1 ANXA1 PLIN5 PLIN5 LOC101955374 LOC101955374 LPGAT1 LPGAT1 FGF1 FGF1 PPP4R3B PPP4R3B ESRRB ESRRB Lhcgr Lhcgr NOS1 NOS1 I3NFT9_ICTTR I3NFT9_ICTTR I3NFV0_ICTTR I3NFV0_ICTTR PPARD PPARD DGAT1 DGAT1 LOC106145384 LOC106145384 PRKAA1 PRKAA1 SCAP SCAP Arpp19 Arpp19 SORBS1 SORBS1 GPLD1 GPLD1 ENSSTOP00000024432 ENSSTOP00000024432 TAZ TAZ Bcl2l1 Bcl2l1 PSEN1 PSEN1 PPARGC1A PPARGC1A ENSSTOP00000026508 ENSSTOP00000026508 APP APP HNF4A HNF4A PPP1R3E PPP1R3E MAS1 MAS1 NR1H3 NR1H3 NR1H2 NR1H2 SLC4A4 SLC4A4 GUCA1B GUCA1B AKT1 AKT1 Supt20h Supt20h NUCB2 NUCB2 ENSSTOP00000029141 ENSSTOP00000029141 SREBF1 SREBF1 IGF1 IGF1 MAPK9 MAPK9 NOS3 NOS3 WDR5 WDR5 ENSSTOP00000031296 ENSSTOP00000031296 PLA2G4A PLA2G4A DAB2 DAB2 TCF7L2 TCF7L2 KAT2A KAT2A STARD4 STARD4 ENSSTOP00000032295 ENSSTOP00000032295 GPER1 GPER1 MT-CO2 MT-CO2 SNCA SNCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP6Bone morphogenetic protein 6. (507 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
PLCD1Phosphoinositide phospholipase C. (756 aa)
ZBTB20Zinc finger and BTB domain containing 20. (744 aa)
GUCA2AGuanylate cyclase activator 2A. (115 aa)
PLA2G3Phospholipase A2 group III. (626 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
APOA1Apolipoprotein A1. (264 aa)
CLYBLCitrate lyase beta like. (341 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
GCKPhosphotransferase. (467 aa)
HTR2A5-hydroxytryptamine receptor 2A. (472 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
FdpsUncharacterized protein; Belongs to the FPP/GGPP synthase family. (353 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
FABP1Fatty acid binding protein 1. (127 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (630 aa)
HNF1AHNF1 homeobox A. (449 aa)
Hif1aUncharacterized protein. (821 aa)
GCGGlucagon. (180 aa)
C1QTNF2C1q and TNF related 2. (320 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (611 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (282 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (389 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
SLC25A12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
Ndufc2NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (120 aa)
ABCD1ATP binding cassette subfamily D member 1. (739 aa)
CD74CD74 molecule. (279 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
Ptgs2EGF-like domain-containing protein. (605 aa)
Foxo1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (535 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (900 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (262 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
GUCA1CGuanylate cyclase activator 1C. (231 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
POU1F1POU domain protein. (317 aa)
LOC101971868Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (487 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ABCD2ATP binding cassette subfamily D member 2. (741 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PID1Phosphotyrosine interaction domain containing 1. (217 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Srebf2BHLH domain-containing protein. (1136 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (480 aa)
RGNRegucalcin. (299 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
Elovl5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (284 aa)
LOC101973014Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
SIRT1Sirtuin 1. (602 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (418 aa)
LOC101956324Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (536 aa)
EPM2AIP1EPM2A interacting protein 1. (608 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (334 aa)
I3MWA1_ICTTRUncharacterized protein. (56 aa)
ABCG1ATP binding cassette subfamily G member 1. (666 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
BEND3BEN domain containing 3. (464 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
APOA5Apolipoprotein A5. (370 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
I3MZU0_ICTTRLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (138 aa)
PRXL2CPeroxiredoxin like 2C. (195 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
MLXIPLMLX interacting protein like. (817 aa)
IGF2Insulin like growth factor 2. (180 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (265 aa)
SEC14L2Uncharacterized protein. (403 aa)
I3N5A9_ICTTRUncharacterized protein. (204 aa)
MID1IP1MID1 interacting protein 1. (184 aa)
Guca1aUncharacterized protein. (202 aa)
GUCA2BGuanylate cyclase activator 2B. (111 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. (115 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
PPP4R3AProtein phosphatase 4 regulatory subunit 3A. (820 aa)
I3N998_ICTTRUncharacterized protein. (305 aa)
ANXA1Annexin. (346 aa)
PLIN5Perilipin; Belongs to the perilipin family. (448 aa)
LOC101955374Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PPP4R3BProtein phosphatase 4 regulatory subunit 3B. (820 aa)
ESRRBEstrogen related receptor beta. (454 aa)
LhcgrLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1329 aa)
I3NFT9_ICTTRCOesterase domain-containing protein. (179 aa)
I3NFV0_ICTTRUncharacterized protein. (216 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
DGAT1O-acyltransferase. (500 aa)
LOC106145384Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (495 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
SCAPSREBF chaperone. (1322 aa)
Arpp19Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (246 aa)
SORBS1Sorbin and SH3 domain containing 1. (931 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (896 aa)
ENSSTOP00000024432MCD domain-containing protein. (267 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (262 aa)
Bcl2l1BH4_2 domain-containing protein. (233 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
ENSSTOP00000026508BH4_2 domain-containing protein. (224 aa)
APPAmyloid beta precursor protein. (739 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (282 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (324 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (444 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (459 aa)
SLC4A4Anion exchange protein. (1094 aa)
GUCA1BGuanylate cyclase activator 1B. (201 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Supt20hUncharacterized protein. (200 aa)
NUCB2Nucleobindin 2. (467 aa)
ENSSTOP00000029141Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (109 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1152 aa)
IGF1Insulin like growth factor 1. (166 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
WDR5WD repeat domain 5. (384 aa)
ENSSTOP00000031296Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (112 aa)
PLA2G4APhospholipase A2. (750 aa)
DAB2DAB adaptor protein 2. (767 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
STARD4StAR related lipid transfer domain containing 4. (222 aa)
ENSSTOP00000032295Uncharacterized protein. (488 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
MT-CO2Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (227 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (14%) [HD]