(100 nodes) Negative regulation of small molecule metabolic process network (Ictidomys tridecemlineatus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (254 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (195 aa)
	I3NH73_ICTTR	Uncharacterized protein. (248 aa)
	APOC3	Apolipoprotein C3. (130 aa)
	C1qtnf3	C1q domain-containing protein. (246 aa)
	CNR1	Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (473 aa)
	ATCAY	ATCAY kinesin light chain interacting caytaxin. (371 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (448 aa)
	SLC22A13	Solute carrier family 22 member 13. (425 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	ERLIN2	ER lipid raft associated 2. (339 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	ETFBKMT	Electron transfer flavoprotein subunit beta lysine methyltransferase. (262 aa)
	SOGA1	Suppressor of glucose, autophagy associated 1. (1422 aa)
	LEPR	Leptin receptor. (1148 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
	FMO2	Dimethylaniline monooxygenase [N-oxide-forming]. (548 aa)
	SLC27A4	Solute carrier family 27 member 4. (643 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	CBFA2T3	CBFA2/RUNX1 partner transcriptional co-repressor 3. (616 aa)
	LOC101960206	Uncharacterized protein. (207 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (270 aa)
	FBP1	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	I3N090_ICTTR	Uncharacterized protein. (207 aa)
	I3MZU0_ICTTR	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (138 aa)
	Ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	GCK	Phosphotransferase. (467 aa)
	NUPR1	Nuclear protein 1, transcriptional regulator. (81 aa)
	FMO1	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	Sik1	Uncharacterized protein. (776 aa)
	TSPO	Translocator protein. (169 aa)
	HPCA	Hippocalcin. (193 aa)
	CLK2	CDC like kinase 2; Belongs to the protein kinase superfamily. (500 aa)
	Dbi	ACB domain-containing protein. (87 aa)
	STAT3	Signal transducer and activator of transcription. (748 aa)
	Rest	Uncharacterized protein. (328 aa)
	SLC25A12	Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa)
	TRIB3	Tribbles pseudokinase 3. (363 aa)
	DKK3	Dickkopf WNT signaling pathway inhibitor 3. (277 aa)
	I3M4W8_ICTTR	Uncharacterized protein. (207 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2328 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (529 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	SLC4A1	Anion exchange protein. (917 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
	FAM3C	Family with sequence similarity 3 member C. (243 aa)
	IER3	Immediate early response 3. (157 aa)
	ACADL	Acyl-CoA dehydrogenase long chain. (430 aa)
	I3MVL6_ICTTR	Uncharacterized protein. (192 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (900 aa)
	Pgp	Uncharacterized protein. (122 aa)
	ENTPD1	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (509 aa)
	MYOG	Myogenin. (224 aa)
	Fmo4	Flavin-containing monooxygenase. (99 aa)
	SIRT1	Sirtuin 1. (602 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (416 aa)
	HPCAL1	Hippocalcin like 1. (193 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
	EP300	E1A binding protein p300. (2423 aa)
	DDIT4	DNA damage inducible transcript 4. (228 aa)
	Brca1	Uncharacterized protein. (353 aa)
	PIBF1	Progesterone immunomodulatory binding factor 1. (757 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	ERFE	Erythroferrone. (284 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
	PLEK	Pleckstrin. (350 aa)
	GFI1	Growth factor independent 1 transcriptional repressor. (422 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
	GIT1	GIT ArfGAP 1. (773 aa)
	WDTC1	WD and tetratricopeptide repeats 1. (680 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (715 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (217 aa)
	FLCN	Folliculin. (579 aa)
	DGAT2	Diacylglycerol O-acyltransferase 2. (388 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (985 aa)
	PRMT3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (530 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
	ACMSD	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1214 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
	ERLIN1	ER lipid raft associated 1. (348 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	Mtch2	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (303 aa)
	NCOR1	Nuclear receptor corepressor 1. (2529 aa)
	ENSSTOP00000027930	Uncharacterized protein. (173 aa)
	MALRD1	MAM and LDL receptor class A domain containing 1. (2068 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	ACADVL	Acyl-CoA dehydrogenase very long chain. (655 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (803 aa)
	C1QTNF12	C1q and TNF related 12. (311 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	DKKL1	Dickkopf like acrosomal protein 1. (230 aa)
	CRY1	Cryptochrome circadian regulator 1. (609 aa)
	SIRT6	Sirtuin 6. (351 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	ACADL	ENSSTOP00000004516	ENSSTOP00000016766	Acetyl-CoA carboxylase beta.	Acyl-CoA dehydrogenase long chain.	0.595
ACACB	ACADVL	ENSSTOP00000004516	ENSSTOP00000027187	Acetyl-CoA carboxylase beta.	Acyl-CoA dehydrogenase very long chain.	0.672
ACACB	Brca1	ENSSTOP00000004516	ENSSTOP00000000449	Acetyl-CoA carboxylase beta.	Uncharacterized protein.	0.793
ACACB	ENSSTOP00000027930	ENSSTOP00000004516	ENSSTOP00000027930	Acetyl-CoA carboxylase beta.	Uncharacterized protein.	0.793
ACACB	TRIB3	ENSSTOP00000004516	ENSSTOP00000007716	Acetyl-CoA carboxylase beta.	Tribbles pseudokinase 3.	0.619
ACADL	ACACB	ENSSTOP00000016766	ENSSTOP00000004516	Acyl-CoA dehydrogenase long chain.	Acetyl-CoA carboxylase beta.	0.595
ACADL	ACADVL	ENSSTOP00000016766	ENSSTOP00000027187	Acyl-CoA dehydrogenase long chain.	Acyl-CoA dehydrogenase very long chain.	0.921
ACADL	ACMSD	ENSSTOP00000016766	ENSSTOP00000009452	Acyl-CoA dehydrogenase long chain.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	0.630
ACADL	CYP7A1	ENSSTOP00000016766	ENSSTOP00000005893	Acyl-CoA dehydrogenase long chain.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.444
ACADL	Dbi	ENSSTOP00000016766	ENSSTOP00000006039	Acyl-CoA dehydrogenase long chain.	ACB domain-containing protein.	0.671
ACADL	SLC27A4	ENSSTOP00000016766	ENSSTOP00000018869	Acyl-CoA dehydrogenase long chain.	Solute carrier family 27 member 4.	0.436
ACADVL	ACACB	ENSSTOP00000027187	ENSSTOP00000004516	Acyl-CoA dehydrogenase very long chain.	Acetyl-CoA carboxylase beta.	0.672
ACADVL	ACADL	ENSSTOP00000027187	ENSSTOP00000016766	Acyl-CoA dehydrogenase very long chain.	Acyl-CoA dehydrogenase long chain.	0.921
ACADVL	ACMSD	ENSSTOP00000027187	ENSSTOP00000009452	Acyl-CoA dehydrogenase very long chain.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	0.558
ACADVL	Dbi	ENSSTOP00000027187	ENSSTOP00000006039	Acyl-CoA dehydrogenase very long chain.	ACB domain-containing protein.	0.667
ACADVL	SLC27A4	ENSSTOP00000027187	ENSSTOP00000018869	Acyl-CoA dehydrogenase very long chain.	Solute carrier family 27 member 4.	0.411
ACMSD	ACADL	ENSSTOP00000009452	ENSSTOP00000016766	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	Acyl-CoA dehydrogenase long chain.	0.630
ACMSD	ACADVL	ENSSTOP00000009452	ENSSTOP00000027187	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	Acyl-CoA dehydrogenase very long chain.	0.558
ADIPOQ	APPL2	ENSSTOP00000014336	ENSSTOP00000012839	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.618
ADIPOQ	Ins	ENSSTOP00000014336	ENSSTOP00000017025	Adiponectin, C1Q and collagen domain containing.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.605