STRINGSTRING
MAP3K5 MAP3K5 SELENOS SELENOS Vkorc1l1 Vkorc1l1 Sod2 Sod2 SLC2A4 SLC2A4 CAT CAT AIFM1 AIFM1 PLA2R1 PLA2R1 Plekha1 Plekha1 PRKAA2 PRKAA2 CHCHD2 CHCHD2 STAU2 STAU2 Ankzf1 Ankzf1 I3MGY8_ICTTR I3MGY8_ICTTR AQP5 AQP5 TNFAIP3 TNFAIP3 MGST1 MGST1 NET1 NET1 FYN FYN EGFR EGFR ETV5 ETV5 MGAT3 MGAT3 ANKRD2 ANKRD2 JAK2 JAK2 STK24 STK24 WNT16 WNT16 XRCC5 XRCC5 SLC4A11 SLC4A11 NCF1 NCF1 MMP9 MMP9 LOC101973389 LOC101973389 PRKRA PRKRA MAP1LC3A MAP1LC3A ATP13A2 ATP13A2 OXR1 OXR1 LRRC8D LRRC8D MELK MELK NOX1 NOX1 NQO1 NQO1 GSKIP GSKIP CHUK CHUK ATG5 ATG5 ZNF580 ZNF580 SLC25A24 SLC25A24 SIRT1 SIRT1 SIN3A SIN3A CAV1 CAV1 ARL6IP5 ARL6IP5 IMPACT IMPACT I3MU87_ICTTR I3MU87_ICTTR STK25 STK25 ENDOG ENDOG ADNP2 ADNP2 BCL2 BCL2 I3MVL6_ICTTR I3MVL6_ICTTR ARNTL ARNTL Ddit3 Ddit3 Ect2 Ect2 MMP2 MMP2 BDKRB2 BDKRB2 SRXN1 SRXN1 PJVK PJVK TRPM2 TRPM2 RELA RELA I3MYT1_ICTTR I3MYT1_ICTTR PDGFRA PDGFRA PAX2 PAX2 PTPRK PTPRK BNIP3 BNIP3 VRK2 VRK2 MAPK8 MAPK8 EPAS1 EPAS1 PPARG PPARG TRPA1 TRPA1 DDIAS DDIAS Hif1a Hif1a I3M4W8_ICTTR I3M4W8_ICTTR BTK BTK FABP1 FABP1 HDAC2 HDAC2 PIK3CA PIK3CA STAT6 STAT6 CHD6 CHD6 Tbc1d24 Tbc1d24 PML PML EPO EPO STK39 STK39 SMPD3 SMPD3 FANCD2 FANCD2 PYCR1 PYCR1 ATF2 ATF2 HDAC6 HDAC6 PCGF2 PCGF2 Rhob Rhob MAPK1 MAPK1 Diablo Diablo RNF7 RNF7 ALDH3B1 ALDH3B1 ROMO1 ROMO1 Gpx5 Gpx5 DAPK1 DAPK1 Aqp1 Aqp1 OSER1 OSER1 MPV17 MPV17 SIGMAR1 SIGMAR1 CDK1 CDK1 PDK2 PDK2 AKT1 AKT1 ENSSTOP00000028494 ENSSTOP00000028494 TMEM161A TMEM161A ENSSTOP00000028944 ENSSTOP00000028944 AXL AXL DYSF DYSF Selenon Selenon PDK1 PDK1 AGAP3 AGAP3 CAPN1 CAPN1 EZH2 EZH2 Cfl1 Cfl1 WNK3 WNK3 ADPRHL2 ADPRHL2 PPARGC1B PPARGC1B GSR GSR HTRA2 HTRA2 MAPK9 MAPK9 NOS3 NOS3 ENSSTOP00000030879 ENSSTOP00000030879 STX2 STX2 NFE2L1 NFE2L1 ENSSTOP00000032126 ENSSTOP00000032126 PARP1 PARP1 MYLK MYLK NFE2L2 NFE2L2 RNF112 RNF112 MAPK7 MAPK7 LRRK2 LRRK2 EDN1 EDN1 STX4 STX4 ZNF622 ZNF622 FER FER MAPK3 MAPK3 BMP4 BMP4 RIPK1 RIPK1 EIF2S1 EIF2S1 CYP1B1 CYP1B1 LOC101976436 LOC101976436 Cpeb2 Cpeb2 RIPK3 RIPK3 PRDX3 PRDX3 ATP7A ATP7A TSPO TSPO NR4A2 NR4A2 FOS FOS PPIF PPIF TRPC6 TRPC6 UCP1 UCP1 STAU1 STAU1 ZNF277 ZNF277 PRKD1 PRKD1 COQ7 COQ7 Pkd2 Pkd2 PDGFD PDGFD Ptgs2 Ptgs2 EIF2AK3 EIF2AK3 Foxo1 Foxo1 SLC7A11 SLC7A11 CCS CCS ERRFI1 ERRFI1 MPO MPO APEX1 APEX1 SESN2 SESN2 KEAP1 KEAP1 LRRC8C LRRC8C ERN1 ERN1 Ggt1 Ggt1 PINK1 PINK1 ATP2A2 ATP2A2 TRPV4 TRPV4 SLC12A6 SLC12A6 Becn1 Becn1 CD36 CD36 LOC101958383 LOC101958383 ATG7 ATG7 PPARGC1A PPARGC1A HMOX1 HMOX1 RELB RELB HSF1 HSF1 ENSSTOP00000027050 ENSSTOP00000027050 SLC2A1 SLC2A1 ENSSTOP00000027321 ENSSTOP00000027321 RBM11 RBM11 SNCA SNCA FANCC FANCC ENSSTOP00000032295 ENSSTOP00000032295 RWDD1 RWDD1 LOC101968119 LOC101968119 I3N090_ICTTR I3N090_ICTTR AIF1 AIF1 Akr1b1 Akr1b1 LONP1 LONP1 LOC101957938 LOC101957938 LOC101960206 LOC101960206 MAPT MAPT RCSD1 RCSD1 ERMP1 ERMP1 TXN TXN STOX1 STOX1 TREX1 TREX1 TP53 TP53 CAPN3 CAPN3 SETX SETX I3N6Q6_ICTTR I3N6Q6_ICTTR GJB2 GJB2 Pdcd10 Pdcd10 SLC1A1 SLC1A1 G6PD G6PD PNPT1 PNPT1 OXSR1 OXSR1 LOC101956215 LOC101956215 I3N9L4_ICTTR I3N9L4_ICTTR PYROXD1 PYROXD1 SIRT2 SIRT2 PRKCD PRKCD RAD52 RAD52 ATM ATM TP53INP1 TP53INP1 SOD1 SOD1 ANXA1 ANXA1 EDNRA EDNRA ZC3H12A ZC3H12A BRF2 BRF2 SPHK1 SPHK1 LRRC8E LRRC8E JUN JUN Prdx2 Prdx2 Foxo3 Foxo3 Pycr2 Pycr2 KDM6B KDM6B Pcna Pcna PARK7 PARK7 MT3 MT3 MSRA MSRA PDGFRB PDGFRB DICER1 DICER1 MAPK13 MAPK13 ATF4 ATF4 NME8 NME8 GPX1 GPX1 LCN2 LCN2 PRDX1 PRDX1 PRKAA1 PRKAA1 SCN2A SCN2A ENSSTOP00000024247 ENSSTOP00000024247 UACA UACA Rps3 Rps3
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1307 aa)
SELENOSSelenoprotein S. (189 aa)
Vkorc1l1VKc domain-containing protein. (111 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
PLA2R1Phospholipase A2 receptor 1. (1467 aa)
Plekha1Uncharacterized protein. (343 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
CHCHD2Coiled-coil-helix-coiled-coil-helix domain containing 2. (151 aa)
STAU2Staufen double-stranded RNA binding protein 2. (607 aa)
Ankzf1ANK_REP_REGION domain-containing protein. (541 aa)
I3MGY8_ICTTRAGC-kinase C-terminal domain-containing protein. (107 aa)
AQP5Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (256 aa)
TNFAIP3TNF alpha induced protein 3. (776 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
NET1Neuroepithelial cell transforming 1. (595 aa)
FYNTyrosine-protein kinase. (537 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
ETV5ETS variant 5. (510 aa)
MGAT3Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase. (537 aa)
ANKRD2Ankyrin repeat domain 2. (336 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
STK24Serine/threonine kinase 24. (432 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
XRCC5X-ray repair cross complementing 5. (734 aa)
SLC4A11Solute carrier family 4 member 11. (862 aa)
NCF1Neutrophil cytosolic factor 1. (405 aa)
MMP9Matrix metallopeptidase 9. (667 aa)
LOC101973389Uncharacterized protein. (182 aa)
PRKRAProtein activator of interferon induced protein kinase EIF2AK2. (313 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1165 aa)
OXR1Oxidation resistance 1. (875 aa)
LRRC8DLeucine rich repeat containing 8 VRAC subunit D. (858 aa)
MELKNon-specific serine/threonine protein kinase. (641 aa)
NOX1NADPH oxidase 1. (561 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (275 aa)
GSKIPGSK3B interacting protein. (143 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ZNF580Zinc finger protein 580. (172 aa)
SLC25A24Solute carrier family 25 member 24; Belongs to the mitochondrial carrier (TC 2.A.29) family. (475 aa)
SIRT1Sirtuin 1. (602 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ARL6IP5PRA1 family protein. (152 aa)
IMPACTImpact RWD domain protein. (297 aa)
I3MU87_ICTTRProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (250 aa)
STK25Serine/threonine kinase 25. (421 aa)
ENDOGEndonuclease. (281 aa)
ADNP2ADNP homeobox 2. (1156 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (633 aa)
Ddit3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
Ect2Uncharacterized protein. (188 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
SRXN1Sulfiredoxin. (153 aa)
PJVKPejvakin. (348 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1499 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
I3MYT1_ICTTRAldo_ket_red domain-containing protein. (263 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PAX2Paired box 2. (417 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1392 aa)
BNIP3BCL2 interacting protein 3. (217 aa)
VRK2VRK serine/threonine kinase 2. (508 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
EPAS1Endothelial PAS domain protein 1. (867 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1. (1044 aa)
DDIASDNA damage induced apoptosis suppressor. (887 aa)
Hif1aUncharacterized protein. (821 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
BTKTyrosine-protein kinase. (659 aa)
FABP1Fatty acid binding protein 1. (127 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2719 aa)
Tbc1d24Uncharacterized protein. (552 aa)
PMLPromyelocytic leukemia. (877 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
STK39Serine/threonine kinase 39. (479 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
FANCD2FA complementation group D2. (1276 aa)
PYCR1Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (319 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
HDAC6Histone deacetylase 6. (1142 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
RhobUncharacterized protein. (196 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
DiabloUncharacterized protein. (234 aa)
RNF7Ring finger protein 7. (113 aa)
ALDH3B1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (468 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
Gpx5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (192 aa)
DAPK1Death associated protein kinase 1. (1432 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
OSER1Oxidative stress responsive serine rich 1. (292 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSSTOP00000028494RRM domain-containing protein. (160 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
ENSSTOP00000028944Uncharacterized protein. (169 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
DYSFDysferlin. (2121 aa)
SelenonSelenoprotein N. (444 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
AGAP3ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (843 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (743 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (757 aa)
Cfl1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (203 aa)
WNK3WNK lysine deficient protein kinase 3. (1745 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (389 aa)
PPARGC1BPPARG coactivator 1 beta. (1033 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (520 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
ENSSTOP00000030879Uncharacterized protein. (105 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (288 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (771 aa)
ENSSTOP00000032126Uncharacterized protein. (141 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
MYLKMyosin light chain kinase. (1897 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
RNF112Ring finger protein 112. (645 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (812 aa)
LRRK2Leucine rich repeat kinase 2. (2520 aa)
EDN1Endothelin 1. (202 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (298 aa)
ZNF622Zinc finger protein 622. (477 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
LOC101976436CSD_1 domain-containing protein. (312 aa)
Cpeb2RRM domain-containing protein. (262 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (491 aa)
PRDX3Peroxiredoxin 3. (257 aa)
ATP7AATPase copper transporting alpha. (1495 aa)
TSPOTranslocator protein. (169 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (903 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
STAU1Staufen double-stranded RNA binding protein 1. (489 aa)
ZNF277Zinc finger protein 277. (458 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (843 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (217 aa)
Pkd2EF-hand domain-containing protein. (892 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
Ptgs2EGF-like domain-containing protein. (605 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1005 aa)
Foxo1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (535 aa)
SLC7A11Solute carrier family 7 member 11. (503 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (459 aa)
MPOMyeloperoxidase. (718 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
SESN2Sestrin 2. (479 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit C. (803 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (972 aa)
Ggt1Uncharacterized protein. (568 aa)
PINK1PTEN induced kinase 1. (574 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
Becn1Beclin 1. (448 aa)
CD36CD36 molecule; Belongs to the CD36 family. (473 aa)
LOC101958383CSD_1 domain-containing protein. (340 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (726 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
HMOX1Heme oxygenase 1. (288 aa)
RELBRELB proto-oncogene, NF-kB subunit. (567 aa)
HSF1Heat shock transcription factor 1. (545 aa)
ENSSTOP00000027050Thioredoxin domain-containing protein. (188 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ENSSTOP00000027321Uncharacterized protein. (207 aa)
RBM11RNA binding motif protein 11. (238 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (578 aa)
ENSSTOP00000032295Uncharacterized protein. (488 aa)
RWDD1RWD domain containing 1. (199 aa)
LOC101968119SERPIN domain-containing protein; Belongs to the serpin family. (197 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
Akr1b1Aldo_ket_red domain-containing protein. (316 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (958 aa)
LOC101957938SERPIN domain-containing protein; Belongs to the serpin family. (377 aa)
LOC101960206Uncharacterized protein. (207 aa)
MAPTMicrotubule-associated protein. (430 aa)
RCSD1RCSD domain containing 1. (387 aa)
ERMP1Endoplasmic reticulum metallopeptidase 1. (903 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
STOX1Storkhead box 1. (983 aa)
TREX1Three prime repair exonuclease 1. (304 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
SETXSenataxin. (2708 aa)
I3N6Q6_ICTTRADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (160 aa)
GJB2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
Pdcd10Programmed cell death 10. (212 aa)
SLC1A1Amino acid transporter. (523 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (784 aa)
OXSR1Oxidative stress responsive kinase 1. (527 aa)
LOC101956215Uncharacterized protein. (195 aa)
I3N9L4_ICTTRProtein kinase domain-containing protein. (388 aa)
PYROXD1Pyridine nucleotide-disulphide oxidoreductase domain 1. (355 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
RAD52RAD52 homolog, DNA repair protein. (422 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
ANXA1Annexin. (346 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
BRF2BRF2 RNA polymerase III transcription initiation factor subunit. (420 aa)
SPHK1Sphingosine kinase 1. (385 aa)
LRRC8ELeucine rich repeat containing 8 VRAC subunit E. (795 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Prdx2Thioredoxin domain-containing protein. (198 aa)
Foxo3Forkhead box O3. (673 aa)
Pycr2Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa)
KDM6BLysine demethylase 6B. (1651 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
MSRAMethionine sulfoxide reductase A. (231 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1904 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
ATF4Activating transcription factor 4. (352 aa)
NME8NME/NM23 family member 8. (518 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (201 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (198 aa)
PRDX1Peroxiredoxin 1. (199 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
ENSSTOP00000024247Uncharacterized protein. (327 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1413 aa)
Rps3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (244 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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