(65 nodes) RNA polymerase binding network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Hnrnpu	B30.2/SPRY domain-containing protein. (411 aa)
	Brca1	Uncharacterized protein. (353 aa)
	GSG1	Germ cell associated 1. (329 aa)
	RPRD2	Regulation of nuclear pre-mRNA domain containing 2. (1470 aa)
	TCERG1L	Transcription elongation regulator 1 like. (510 aa)
	RPRD1A	Regulation of nuclear pre-mRNA domain containing 1A. (312 aa)
	BRD4	Bromodomain containing 4. (1397 aa)
	ELOF1	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (83 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1256 aa)
	SCAF4	SR-related CTD associated factor 4. (1064 aa)
	ZNF326	Zinc finger protein 326; Belongs to the AKAP95 family. (563 aa)
	PPIB	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	STOM	Stomatin. (284 aa)
	PCF11	PCF11 cleavage and polyadenylation factor subunit. (1684 aa)
	UVSSA	UV stimulated scaffold protein A. (743 aa)
	ANP32B	Acidic nuclear phosphoprotein 32 family member B. (251 aa)
	Bivm	Uncharacterized protein. (503 aa)
	LOC101968680	ERCC excision repair 5, endonuclease. (1170 aa)
	PCIF1	PDX1 C-terminal inhibiting factor 1. (706 aa)
	PKN2	Protein kinase N2. (982 aa)
	STOML3	Stomatin like 3. (292 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (862 aa)
	SMYD2	SET and MYND domain containing 2. (429 aa)
	RTF1	RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
	PER2	Period circadian regulator 2. (1297 aa)
	RRN3	RRN3 homolog, RNA polymerase I transcription factor. (655 aa)
	SPTY2D1	SPT2 chromatin protein domain containing 1. (685 aa)
	URI1	URI1 prefoldin like chaperone. (456 aa)
	CCNT2	Cyclin T2; Belongs to the cyclin family. (728 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (865 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
	RPRD1B	Regulation of nuclear pre-mRNA domain containing 1B. (326 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
	YTHDC2	YTH domain containing 2. (1433 aa)
	FBF1	Fas binding factor 1. (1186 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1176 aa)
	WAC	WW domain containing adaptor with coiled-coil. (646 aa)
	WDR43	WD repeat domain 43. (679 aa)
	PAF1	PAF1 homolog, Paf1/RNA polymerase II complex component. (529 aa)
	DHX9	DExH-box helicase 9. (1328 aa)
	BCL2L2-PABPN1	RRM domain-containing protein. (178 aa)
	TCERG1	Transcription elongation regulator 1. (1087 aa)
	ZFP36	ZFP36 ring finger protein. (324 aa)
	SMYD3	SET and MYND domain containing 3. (428 aa)
	WDHD1	WD repeat and HMG-box DNA binding protein 1. (1106 aa)
	GSG1L	GSG1 like. (215 aa)
	CDC73	Cell division cycle 73. (531 aa)
	SCAF1	SR-related CTD associated factor 1. (1245 aa)
	ESRRB	Estrogen related receptor beta. (454 aa)
	LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
	CCNT1	Cyclin T1; Belongs to the cyclin family. (726 aa)
	NEDD4	E3 ubiquitin-protein ligase. (901 aa)
	ENSSTOP00000025974	RTR1-type domain-containing protein. (86 aa)
	CCAR2	Cell cycle and apoptosis regulator 2. (920 aa)
	IWS1	Interacts with SUPT6H, CTD assembly factor 1. (845 aa)
	ENSSTOP00000027930	Uncharacterized protein. (173 aa)
	MAF1	MAF1 homolog, negative regulator of RNA polymerase III. (347 aa)
	GTF2B	General transcription factor IIB. (316 aa)
	SCAF8	SR-related CTD associated factor 8. (1268 aa)
	ENSSTOP00000029359	Uncharacterized protein. (65 aa)
	NCOA3	Nuclear receptor coactivator. (1413 aa)
	PHRF1	PHD and ring finger domains 1. (1658 aa)
	ENSSTOP00000030990	WD_REPEATS_REGION domain-containing protein. (120 aa)
	SUPT4H1	SPT4 homolog, DSIF elongation factor subunit. (110 aa)
	BIN1	Bridging integrator 1. (609 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSSTOP00000009740	ENSSTOP00000007282	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.990
AGO1	DHX9	ENSSTOP00000009740	ENSSTOP00000014588	Argonaute RISC component 1; Belongs to the argonaute family.	DExH-box helicase 9.	0.671
AGO1	Hnrnpu	ENSSTOP00000009740	ENSSTOP00000000138	Argonaute RISC component 1; Belongs to the argonaute family.	B30.2/SPRY domain-containing protein.	0.411
AGO1	ZFP36	ENSSTOP00000009740	ENSSTOP00000017350	Argonaute RISC component 1; Belongs to the argonaute family.	ZFP36 ring finger protein.	0.570
AGO2	AGO1	ENSSTOP00000007282	ENSSTOP00000009740	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.990
AGO2	CTR9	ENSSTOP00000007282	ENSSTOP00000012186	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.578
AGO2	DHX9	ENSSTOP00000007282	ENSSTOP00000014588	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DExH-box helicase 9.	0.915
AGO2	ZFP36	ENSSTOP00000007282	ENSSTOP00000017350	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	ZFP36 ring finger protein.	0.717
BCL2L2-PABPN1	BRD4	ENSSTOP00000016434	ENSSTOP00000003087	RRM domain-containing protein.	Bromodomain containing 4.	0.417
BCL2L2-PABPN1	DHX9	ENSSTOP00000016434	ENSSTOP00000014588	RRM domain-containing protein.	DExH-box helicase 9.	0.951
BCL2L2-PABPN1	PCF11	ENSSTOP00000016434	ENSSTOP00000004945	RRM domain-containing protein.	PCF11 cleavage and polyadenylation factor subunit.	0.886
BCL2L2-PABPN1	YTHDC2	ENSSTOP00000016434	ENSSTOP00000011876	RRM domain-containing protein.	YTH domain containing 2.	0.683
BIN1	NEDD4	ENSSTOP00000032241	ENSSTOP00000025467	Bridging integrator 1.	E3 ubiquitin-protein ligase.	0.401
BRD4	BCL2L2-PABPN1	ENSSTOP00000003087	ENSSTOP00000016434	Bromodomain containing 4.	RRM domain-containing protein.	0.417
BRD4	CCNT1	ENSSTOP00000003087	ENSSTOP00000023449	Bromodomain containing 4.	Cyclin T1; Belongs to the cyclin family.	0.952
BRD4	CCNT2	ENSSTOP00000003087	ENSSTOP00000009458	Bromodomain containing 4.	Cyclin T2; Belongs to the cyclin family.	0.737
BRD4	LEO1	ENSSTOP00000003087	ENSSTOP00000022249	Bromodomain containing 4.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.410
BRD4	RTF1	ENSSTOP00000003087	ENSSTOP00000007490	Bromodomain containing 4.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.406
BRD4	SMYD2	ENSSTOP00000003087	ENSSTOP00000007299	Bromodomain containing 4.	SET and MYND domain containing 2.	0.577
BRD4	TCERG1	ENSSTOP00000003087	ENSSTOP00000016605	Bromodomain containing 4.	Transcription elongation regulator 1.	0.563