STRINGSTRING
CD81 CD81 DNAJA3 DNAJA3 SELENOK SELENOK KIT KIT MAPK3 MAPK3 NCK2 NCK2 LOC101955676 LOC101955676 NCK1 NCK1 IL1B IL1B Cd86 Cd86 ITGAL ITGAL CCL19 CCL19 TYK2 TYK2 HLA-DPA1 HLA-DPA1 HLA-DPB1 HLA-DPB1 TFRC TFRC FOXP3 FOXP3 Zp3 Zp3 BTK BTK I3M4W8_ICTTR I3M4W8_ICTTR IL12B IL12B BLM BLM IL6ST IL6ST IL23R IL23R IL15 IL15 SYK SYK CD40LG CD40LG SLC4A1 SLC4A1 JAK2 JAK2 STAT5B STAT5B STAT5A STAT5A NMBR NMBR Dhps Dhps SLAMF1 SLAMF1 TRAF6 TRAF6 VTCN1 VTCN1 CD6 CD6 Card11 Card11 JAK3 JAK3 IL13 IL13 SASH3 SASH3 CORO1A CORO1A IL27RA IL27RA CD74 CD74 MPL MPL TIRAP TIRAP TCF3 TCF3 BTNL2 BTNL2 ZAP70 ZAP70 IGFBP2 IGFBP2 Cd59 Cd59 PPP3CA PPP3CA ADK ADK SLC7A1 SLC7A1 PYCARD PYCARD MYD88 MYD88 EPO EPO CSF2 CSF2 LOC101970885 LOC101970885 IL12A IL12A MAPK1 MAPK1 RIPK2 RIPK2 SPTA1 SPTA1 IL34 IL34 CLCF1 CLCF1 ST6GAL1 ST6GAL1 CD274 CD274 PDCD1LG2 PDCD1LG2 IL23A IL23A IL2 IL2 I3MQY6_ICTTR I3MQY6_ICTTR CARMIL2 CARMIL2 IL18 IL18 LEP LEP SHH SHH ATAD5 ATAD5 BCL2 BCL2 I3MVL6_ICTTR I3MVL6_ICTTR PELI1 PELI1 CCDC88B CCDC88B RAC2 RAC2 CSF1R CSF1R TLR4 TLR4 I3N090_ICTTR I3N090_ICTTR AIF1 AIF1 FGF10 FGF10 NCKAP1L NCKAP1L CD28 CD28 LOC101960206 LOC101960206 Vcam1 Vcam1 PRKCQ PRKCQ IGF2 IGF2 EFNB1 EFNB1 CD276 CD276 LOC101972772 LOC101972772 OCSTAMP OCSTAMP CDKN1A CDKN1A HES1 HES1 PTH PTH CSF1 CSF1 GPR183 GPR183 IL2RA IL2RA ANXA1 ANXA1 WNT3A WNT3A TNFSF13B TNFSF13B LOC101959667 LOC101959667 SLC39A10 SLC39A10 LOC101972479 LOC101972479 CD4 CD4 CD40 CD40 I3NF27_ICTTR I3NF27_ICTTR GSK3B GSK3B BST1 BST1 LOC101961439 LOC101961439 Rps3 Rps3 FLT3LG FLT3LG FADD FADD BCL6 BCL6 TGFBR2 TGFBR2 AGER AGER ENSSTOP00000025794 ENSSTOP00000025794 CD320 CD320 PTPRC PTPRC EPHB2 EPHB2 CHRNB2 CHRNB2 ENSSTOP00000027615 ENSSTOP00000027615 KITLG KITLG Tnfrsf13c Tnfrsf13c NFATC2 NFATC2 LYN LYN IGF1 IGF1 IL7 IL7 MEF2C MEF2C ZNF335 ZNF335 IL21 IL21 PTK2 PTK2 GPAM GPAM VAV3 VAV3 LOC101968601 LOC101968601
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD81Tetraspanin. (214 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (479 aa)
SELENOKSelenoprotein K. (91 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
NCK2Cytoplasmic protein. (380 aa)
LOC101955676RING-type domain-containing protein. (326 aa)
NCK1Cytoplasmic protein. (377 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
Cd86Ig-like domain-containing protein. (289 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1149 aa)
CCL19C-C motif chemokine. (135 aa)
TYK2Tyrosine-protein kinase. (1194 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (288 aa)
TFRCTransferrin receptor. (760 aa)
FOXP3Forkhead box P3. (431 aa)
Zp3ZP domain-containing protein. (319 aa)
BTKTyrosine-protein kinase. (659 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
BLMBLM RecQ like helicase. (1414 aa)
IL6STInterleukin 6 signal transducer. (928 aa)
IL23RInterleukin 23 receptor. (644 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (134 aa)
SYKTyrosine-protein kinase. (626 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (259 aa)
SLC4A1Anion exchange protein. (917 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
STAT5BSignal transducer and activator of transcription. (765 aa)
STAT5ASignal transducer and activator of transcription. (773 aa)
NMBRNeuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
DhpsUncharacterized protein. (369 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (335 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
CD6CD6 molecule. (670 aa)
Card11Uncharacterized protein. (1152 aa)
JAK3Tyrosine-protein kinase. (1042 aa)
IL13Interleukin 13. (130 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
IL27RAInterleukin 27 receptor subunit alpha. (569 aa)
CD74CD74 molecule. (279 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (648 aa)
TIRAPTIR domain containing adaptor protein. (222 aa)
TCF3Transcription factor 3. (681 aa)
BTNL2Butyrophilin like 2. (475 aa)
ZAP70Tyrosine-protein kinase. (608 aa)
IGFBP2Insulin like growth factor binding protein 2. (308 aa)
Cd59UPAR/Ly6 domain-containing protein. (131 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
ADKAdenosine kinase. (362 aa)
SLC7A1Solute carrier family 7 member 1. (629 aa)
PYCARDPYD and CARD domain containing. (194 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
CSF2Colony stimulating factor 2. (138 aa)
LOC101970885SCY domain-containing protein. (113 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2417 aa)
IL34Interleukin 34. (240 aa)
CLCF1Cardiotrophin like cytokine factor 1. (219 aa)
ST6GAL1ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (406 aa)
CD274CD274 molecule. (293 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (259 aa)
IL23AInterleukin 23 subunit alpha. (185 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
I3MQY6_ICTTRUncharacterized protein. (238 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1403 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
ATAD5ATPase family AAA domain containing 5. (1897 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
CCDC88BCoiled-coil domain containing 88B. (1234 aa)
RAC2Rac family small GTPase 2. (192 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
CD28CD28 molecule. (221 aa)
LOC101960206Uncharacterized protein. (207 aa)
Vcam1Vascular cell adhesion molecule 1. (657 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
IGF2Insulin like growth factor 2. (180 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (345 aa)
CD276CD276 molecule. (316 aa)
LOC101972772A_deaminase domain-containing protein. (352 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (469 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. (115 aa)
CSF1Colony stimulating factor 1. (497 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (357 aa)
IL2RAInterleukin 2 receptor subunit alpha. (251 aa)
ANXA1Annexin. (346 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (280 aa)
LOC101959667Ig-like domain-containing protein. (272 aa)
SLC39A10Solute carrier family 39 member 10. (830 aa)
LOC101972479A_deaminase domain-containing protein. (338 aa)
CD4CD4 molecule. (451 aa)
CD40CD40 molecule. (284 aa)
I3NF27_ICTTRRas-GAP domain-containing protein. (574 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
BST1Bone marrow stromal cell antigen 1. (311 aa)
LOC101961439TIR domain-containing protein. (1051 aa)
Rps3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (244 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (299 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
BCL6BCL6 transcription repressor. (706 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
AGERAdvanced glycosylation end-product specific receptor. (450 aa)
ENSSTOP00000025794Uncharacterized protein. (78 aa)
CD320CD320 molecule. (258 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1180 aa)
EPHB2EPH receptor B2. (978 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (599 aa)
ENSSTOP00000027615Uncharacterized protein. (247 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
Tnfrsf13cUncharacterized protein. (104 aa)
NFATC2Nuclear factor of activated T cells 2. (844 aa)
LYNTyrosine-protein kinase. (512 aa)
IGF1Insulin like growth factor 1. (166 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (159 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ZNF335Zinc finger protein 335. (1371 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (827 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
LOC101968601Uncharacterized protein. (80 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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