(31 nodes) Response to cholesterol network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101956324	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (536 aa)
	GRAMD1C	GRAM domain containing 1C. (662 aa)
	OSBPL7	Oxysterol-binding protein; Belongs to the OSBP family. (920 aa)
	PMVK	Phosphomevalonate kinase. (192 aa)
	MLC1	Modulator of VRAC current 1. (388 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	GRAMD1A	GRAM domain containing 1A. (719 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	LOC101971868	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa)
	LOC101968303	C-C motif chemokine. (93 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
	ABCA2	ATP binding cassette subfamily A member 2. (2414 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1540 aa)
	GRAMD1B	GRAM domain containing 1B. (723 aa)
	LOC101973014	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	I3N3Z2_ICTTR	Uncharacterized protein. (159 aa)
	CCR5	C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (351 aa)
	INHBB	Inhibin subunit beta B. (336 aa)
	F7	Coagulation factor VII; Belongs to the peptidase S1 family. (375 aa)
	I3NFT9_ICTTR	COesterase domain-containing protein. (179 aa)
	LOC106145384	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (495 aa)
	LRP8	LDL receptor related protein 8. (940 aa)
	CYP8B1	Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (896 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	DAG1	Dystroglycan 1. (895 aa)
	Inhba	TGF_BETA_2 domain-containing protein. (133 aa)
	PTCH1	Patched 1. (1450 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (771 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR5	LOC101968303	ENSSTOP00000019243	ENSSTOP00000011933	C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.955
CYP7A1	CYP8B1	ENSSTOP00000005893	ENSSTOP00000023860	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family.	0.701
CYP8B1	CYP7A1	ENSSTOP00000023860	ENSSTOP00000005893	Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.701
GPLD1	TGFB1	ENSSTOP00000024219	ENSSTOP00000008874	Glycosylphosphatidylinositol specific phospholipase D1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.641
GRAMD1A	GRAMD1B	ENSSTOP00000003558	ENSSTOP00000014728	GRAM domain containing 1A.	GRAM domain containing 1B.	0.401
GRAMD1A	I3N3Z2_ICTTR	ENSSTOP00000003558	ENSSTOP00000019088	GRAM domain containing 1A.	Uncharacterized protein.	0.935
GRAMD1B	GRAMD1A	ENSSTOP00000014728	ENSSTOP00000003558	GRAM domain containing 1B.	GRAM domain containing 1A.	0.401
GRAMD1B	GRAMD1C	ENSSTOP00000014728	ENSSTOP00000000266	GRAM domain containing 1B.	GRAM domain containing 1C.	0.408
GRAMD1B	I3N3Z2_ICTTR	ENSSTOP00000014728	ENSSTOP00000019088	GRAM domain containing 1B.	Uncharacterized protein.	0.900
GRAMD1C	GRAMD1B	ENSSTOP00000000266	ENSSTOP00000014728	GRAM domain containing 1C.	GRAM domain containing 1B.	0.408
GRAMD1C	I3N3Z2_ICTTR	ENSSTOP00000000266	ENSSTOP00000019088	GRAM domain containing 1C.	Uncharacterized protein.	0.919
I3N3Z2_ICTTR	GRAMD1A	ENSSTOP00000019088	ENSSTOP00000003558	Uncharacterized protein.	GRAM domain containing 1A.	0.935
I3N3Z2_ICTTR	GRAMD1B	ENSSTOP00000019088	ENSSTOP00000014728	Uncharacterized protein.	GRAM domain containing 1B.	0.900
I3N3Z2_ICTTR	GRAMD1C	ENSSTOP00000019088	ENSSTOP00000000266	Uncharacterized protein.	GRAM domain containing 1C.	0.919
INHBB	Inhba	ENSSTOP00000019906	ENSSTOP00000029829	Inhibin subunit beta B.	TGF_BETA_2 domain-containing protein.	0.950
INHBB	SMAD2	ENSSTOP00000019906	ENSSTOP00000003397	Inhibin subunit beta B.	Mothers against decapentaplegic homolog.	0.658
INHBB	TGFB1	ENSSTOP00000019906	ENSSTOP00000008874	Inhibin subunit beta B.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.844
INHBB	TGFBR1	ENSSTOP00000019906	ENSSTOP00000012159	Inhibin subunit beta B.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.844
INHBB	TGFBR2	ENSSTOP00000019906	ENSSTOP00000024905	Inhibin subunit beta B.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.578
Inhba	INHBB	ENSSTOP00000029829	ENSSTOP00000019906	TGF_BETA_2 domain-containing protein.	Inhibin subunit beta B.	0.950