STRINGSTRING
WNT5A WNT5A KCNK3 KCNK3 MYLK MYLK NFE2L2 NFE2L2 HESX1 HESX1 LGMN LGMN LRRK2 LRRK2 ALAD ALAD I3LX54_ICTTR I3LX54_ICTTR GSK3A GSK3A MAPK3 MAPK3 HPCAL1 HPCAL1 EIF2S1 EIF2S1 OGG1 OGG1 Clic4 Clic4 KRT10 KRT10 ACER1 ACER1 SLC25A23 SLC25A23 DAXX DAXX BRAF BRAF ATP7A ATP7A TPH2 TPH2 FN1 FN1 TSPO TSPO NFATC4 NFATC4 FOS FOS PPIF PPIF SLC12A2 SLC12A2 KCNJ1 KCNJ1 HSD17B1 HSD17B1 GLRA2 GLRA2 Pkd2 Pkd2 Rasgrp2 Rasgrp2 SYT13 SYT13 RASAL1 RASAL1 SYT11 SYT11 CPNE3 CPNE3 GSN GSN LOC101962071 LOC101962071 CPNE8 CPNE8 PLCG2 PLCG2 GLRA3 GLRA3 Syt15 Syt15 MT4 MT4 FUS FUS ATP13A2 ATP13A2 MAP1LC3A MAP1LC3A LOC101973389 LOC101973389 MMP9 MMP9 NCF1 NCF1 Hnrnpa1 Hnrnpa1 EGFR EGFR Rasa4b Rasa4b SLC13A5 SLC13A5 ITPKA ITPKA SLC34A1 SLC34A1 Fabp4 Fabp4 HPCA HPCA CALR CALR NCSTN NCSTN SMPD1 SMPD1 SYT4 SYT4 SLC41A1 SLC41A1 IREB2 IREB2 HVCN1 HVCN1 CRHBP CRHBP CLDN1 CLDN1 EIF2AK3 EIF2AK3 SYT9 SYT9 CPNE2 CPNE2 SYT2 SYT2 PRKAA2 PRKAA2 ALOX5AP ALOX5AP ABCB6 ABCB6 AQP2 AQP2 SYT12 SYT12 DPEP1 DPEP1 KCNH1 KCNH1 BNIP3 BNIP3 HRG HRG MAPK8 MAPK8 PPARG PPARG I3MJU8_ICTTR I3MJU8_ICTTR NEK7 NEK7 TFR2 TFR2 SMPD3 SMPD3 LOC101975452 LOC101975452 MT2A MT2A MAPK1 MAPK1 PRNP PRNP Aqp1 Aqp1 I3MQ94_ICTTR I3MQ94_ICTTR GLRA1 GLRA1 PARP1 PARP1 MCOLN1 MCOLN1 ATP7B ATP7B CHUK CHUK CREB1 CREB1 SLC25A24 SLC25A24 KCNJ10 KCNJ10 SYT5 SYT5 CDKN1B CDKN1B SHH SHH NFATC3 NFATC3 SYT1 SYT1 MYOG MYOG ENDOG ENDOG A3GALT2 A3GALT2 Cacna1h Cacna1h Ect2 Ect2 RYR1 RYR1 TRPM2 TRPM2 BMP6 BMP6 Cebpa Cebpa CPNE7 CPNE7 MTF1 MTF1 FBP1 FBP1 TIGAR TIGAR NPTX1 NPTX1 NEUROD2 NEUROD2 SLC40A1 SLC40A1 CAPN3 CAPN3 CPNE6 CPNE6 ALOX15 ALOX15 INHBB INHBB SYT17 SYT17 FOXA2 FOXA2 SLC1A1 SLC1A1 AOC1 AOC1 XRCC4 XRCC4 CYP1A2 CYP1A2 GPR39 GPR39 SERPINF1 SERPINF1 CPNE5 CPNE5 ID2 ID2 DMTN DMTN JUN JUN CHP2 CHP2 ITPKB ITPKB TH TH MT3 MT3 CYBB CYBB LOC101967418 LOC101967418 ITPKC ITPKC LOC101964462 LOC101964462 FOSB FOSB LIG4 LIG4 GRIN2A GRIN2A SYT6 SYT6 LOC101961439 LOC101961439 ATF4 ATF4 SYT10 SYT10 SYT8 SYT8 LOC101971282 LOC101971282 ENSSTOP00000024016 ENSSTOP00000024016 PRKAA1 PRKAA1 GPLD1 GPLD1 CARF CARF DLG4 DLG4 MEF2A MEF2A CPNE9 CPNE9 Becn1 Becn1 JUNB JUNB ENSSTOP00000025412 ENSSTOP00000025412 ENSSTOP00000025799 ENSSTOP00000025799 LOC101968724 LOC101968724 MECP2 MECP2 HMOX1 HMOX1 P2RX4 P2RX4 HSF1 HSF1 CPNE1 CPNE1 TFAP2A TFAP2A GABRB3 GABRB3 B2M B2M IQGAP1 IQGAP1 KCNB1 KCNB1 NLGN1 NLGN1 ADD1 ADD1 AKT1 AKT1 ADCY7 ADCY7 ENSSTOP00000028903 ENSSTOP00000028903 ENSSTOP00000028967 ENSSTOP00000028967 SYT7 SYT7 ENSSTOP00000029812 ENSSTOP00000029812 LOC101961297 LOC101961297 EEF2K EEF2K SCN5A SCN5A ADCY8 ADCY8 MAPK9 MAPK9 MEF2C MEF2C ASPH ASPH Sumo1 Sumo1 LOC101975171 LOC101975171 NFE2L1 NFE2L1 ENSSTOP00000031875 ENSSTOP00000031875 KCNA1 KCNA1 ENSSTOP00000032132 ENSSTOP00000032132 WNK1 WNK1 ENSSTOP00000032440 ENSSTOP00000032440 ENSSTOP00000032442 ENSSTOP00000032442 CDH1 CDH1 SNCA SNCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
KCNK3Potassium two pore domain channel subfamily K member 3; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (364 aa)
MYLKMyosin light chain kinase. (1897 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
HESX1HESX homeobox 1. (184 aa)
LGMNLegumain. (433 aa)
LRRK2Leucine rich repeat kinase 2. (2520 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (329 aa)
I3LX54_ICTTRUncharacterized protein. (327 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (395 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
HPCAL1Hippocalcin like 1. (193 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
OGG18-oxoguanine DNA glycosylase. (344 aa)
Clic4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (229 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (563 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (515 aa)
DAXXDeath domain associated protein. (740 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
ATP7AATPase copper transporting alpha. (1495 aa)
TPH2Tryptophan hydroxylase 2. (491 aa)
FN1Fibronectin 1. (2474 aa)
TSPOTranslocator protein. (169 aa)
NFATC4Nuclear factor of activated T cells 4. (890 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
SLC12A2Solute carrier family 12 member 2. (1108 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (391 aa)
HSD17B1Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
Pkd2EF-hand domain-containing protein. (892 aa)
Rasgrp2Uncharacterized protein. (231 aa)
SYT13Synaptotagmin 13. (365 aa)
RASAL1RAS protein activator like 1. (812 aa)
SYT11Synaptotagmin 11. (419 aa)
CPNE3Copine 3. (533 aa)
GSNGelsolin. (748 aa)
LOC101962071Uncharacterized protein. (380 aa)
CPNE8Copine 8. (563 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
GLRA3Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (469 aa)
Syt15Uncharacterized protein. (410 aa)
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
FUSFUS RNA binding protein. (466 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1165 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
LOC101973389Uncharacterized protein. (182 aa)
MMP9Matrix metallopeptidase 9. (667 aa)
NCF1Neutrophil cytosolic factor 1. (405 aa)
Hnrnpa1Uncharacterized protein. (374 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
Rasa4bUncharacterized protein. (667 aa)
SLC13A5Solute carrier family 13 member 5. (570 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (460 aa)
SLC34A1Solute carrier family 34 member 1. (639 aa)
Fabp4Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). FABPs are important elements related to the hibernating state in mammals. (132 aa)
HPCAHippocalcin. (193 aa)
CALRCalreticulin. (418 aa)
NCSTNNicastrin. (709 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
SYT4Synaptotagmin 4. (424 aa)
SLC41A1Solute carrier family 41 member 1. (514 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (963 aa)
HVCN1Hydrogen voltage gated channel 1. (271 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1005 aa)
SYT9Synaptotagmin 9. (491 aa)
CPNE2Copine 2. (571 aa)
SYT2Synaptotagmin 2. (419 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (161 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (843 aa)
AQP2Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
SYT12Synaptotagmin 12. (424 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (410 aa)
KCNH1Potassium voltage-gated channel subfamily H member 1. (962 aa)
BNIP3BCL2 interacting protein 3. (217 aa)
HRGHistidine rich glycoprotein. (531 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
I3MJU8_ICTTRCopine domain-containing protein. (108 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
TFR2Transferrin receptor 2. (802 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
LOC101975452Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
MT2AMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
PRNPMajor prion protein; Belongs to the prion family. (247 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
I3MQ94_ICTTRUncharacterized protein. (1171 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
MCOLN1Mucolipin 1. (580 aa)
ATP7BATPase copper transporting beta. (1464 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SLC25A24Solute carrier family 25 member 24; Belongs to the mitochondrial carrier (TC 2.A.29) family. (475 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
SYT5Synaptotagmin 5. (386 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
SYT1Synaptotagmin 1. (422 aa)
MYOGMyogenin. (224 aa)
ENDOGEndonuclease. (281 aa)
A3GALT2Alpha 1,3-galactosyltransferase 2. (341 aa)
Cacna1hUncharacterized protein. (2259 aa)
Ect2Uncharacterized protein. (188 aa)
RYR1Ryanodine receptor 1. (4864 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1499 aa)
BMP6Bone morphogenetic protein 6. (507 aa)
CebpaUncharacterized protein. (122 aa)
CPNE7Copine 7. (554 aa)
MTF1Metal regulatory transcription factor 1. (661 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
NPTX1Neuronal pentraxin 1. (432 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (574 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
CPNE6Copine 6. (557 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
INHBBInhibin subunit beta B. (336 aa)
SYT17Synaptotagmin 17. (470 aa)
FOXA2Forkhead box A2. (463 aa)
SLC1A1Amino acid transporter. (523 aa)
AOC1Amine oxidase. (688 aa)
XRCC4X-ray repair cross complementing 4. (330 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (515 aa)
GPR39G protein-coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (456 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (417 aa)
CPNE5Copine 5. (593 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
DMTNDematin actin binding protein. (405 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CHP2Calcineurin like EF-hand protein 2. (195 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (951 aa)
THTyrosine hydroxylase. (497 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
CYBBCytochrome b-245 beta chain. (549 aa)
LOC101967418Uncharacterized protein. (2364 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (667 aa)
LOC101964462Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
LIG4DNA ligase. (911 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1423 aa)
SYT6Synaptotagmin 6. (510 aa)
LOC101961439TIR domain-containing protein. (1051 aa)
ATF4Activating transcription factor 4. (352 aa)
SYT10Synaptotagmin 10. (523 aa)
SYT8Synaptotagmin 8. (387 aa)
LOC101971282RRM domain-containing protein. (452 aa)
ENSSTOP00000024016RRM domain-containing protein. (234 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (896 aa)
CARFCalcium responsive transcription factor. (718 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
MEF2AMyocyte enhancer factor 2A. (496 aa)
CPNE9Copine family member 9. (553 aa)
Becn1Beclin 1. (448 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
ENSSTOP00000025412C2 domain-containing protein. (144 aa)
ENSSTOP00000025799LAM_G_DOMAIN domain-containing protein. (176 aa)
LOC101968724Uncharacterized protein. (292 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
HMOX1Heme oxygenase 1. (288 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
HSF1Heat shock transcription factor 1. (545 aa)
CPNE1Copine 1. (537 aa)
TFAP2ATranscription factor AP-2 alpha. (477 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (493 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (123 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (859 aa)
NLGN1Neuroligin 1. (843 aa)
ADD1Adducin 1. (764 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
ENSSTOP00000028903Uncharacterized protein. (316 aa)
ENSSTOP00000028967Uncharacterized protein. (1864 aa)
SYT7Synaptotagmin 7. (688 aa)
ENSSTOP00000029812Small ubiquitin-related modifier. (112 aa)
LOC101961297Uncharacterized protein. (302 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2019 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ASPHAspartate beta-hydroxylase. (770 aa)
Sumo1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa)
LOC101975171Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (771 aa)
ENSSTOP00000031875Uncharacterized protein. (274 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (476 aa)
ENSSTOP00000032132RRM domain-containing protein. (282 aa)
WNK1WNK lysine deficient protein kinase 1. (2635 aa)
ENSSTOP00000032440G_PROTEIN_RECEP_F2_4 domain-containing protein. (318 aa)
ENSSTOP00000032442ANK_REP_REGION domain-containing protein. (460 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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