STRINGSTRING
DTL DTL DNTT DNTT POLG2 POLG2 I3MI67_ICTTR I3MI67_ICTTR POLD1 POLD1 POLL POLL POLH POLH TEP1 TEP1 PINX1 PINX1 POLQ POLQ MAD2L2 MAD2L2 Rad50 Rad50 POT1 POT1 LOC101954868 LOC101954868 ENSSTOP00000029795 ENSSTOP00000029795 POLDIP2 POLDIP2 Polk Polk TELO2 TELO2 LIG1 LIG1 ENSSTOP00000026272 ENSSTOP00000026272 LOC101973038 LOC101973038 TERF2 TERF2 REV3L REV3L PTGES3 PTGES3 LOC101962631 LOC101962631 Pola1 Pola1 LOC101963381 LOC101963381 LIG4 LIG4 LOC101975245 LOC101975245 I3NE23_ICTTR I3NE23_ICTTR Pcna Pcna Phb Phb HSP90AB1 HSP90AB1 TK1 TK1 SPHK1 SPHK1 Zbtb1 Zbtb1 SPATA22 SPATA22 TREX1 TREX1 TERT TERT I3N2L3_ICTTR I3N2L3_ICTTR Cdkn2d Cdkn2d Pold3 Pold3 POLN POLN Dkc1 Dkc1 WRAP53 WRAP53 POLM POLM POLD2 POLD2 I3M249_ICTTR I3M249_ICTTR PAM16 PAM16 Pola2 Pola2 POLI POLI PRIMPOL PRIMPOL GAR1 GAR1 POLB POLB LIG3 LIG3 POLG POLG POLE2 POLE2 SPRTN SPRTN HSP90AA1 HSP90AA1 Pclaf Pclaf I3MXT5_ICTTR I3MXT5_ICTTR Nop10 Nop10 RPA1 RPA1 POLE POLE CCN2 CCN2 I3MU87_ICTTR I3MU87_ICTTR SIRT1 SIRT1 WRNIP1 WRNIP1 ACD ACD LOX LOX Pold4 Pold4 VCP VCP REV1 REV1 SMPD3 SMPD3 WRN WRN HROB HROB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (467 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (484 aa)
I3MI67_ICTTRPUA domain-containing protein. (493 aa)
POLD1DNA polymerase. (1106 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
POLHDNA polymerase eta. (714 aa)
TEP1Telomerase associated protein 1. (2608 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (344 aa)
POLQDNA polymerase theta. (2588 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
Rad50Zinc-hook domain-containing protein. (1312 aa)
POT1Protection of telomeres 1. (705 aa)
LOC101954868Uncharacterized protein. (686 aa)
ENSSTOP00000029795PAF domain-containing protein. (104 aa)
POLDIP2DNA polymerase delta interacting protein 2. (368 aa)
PolkUmuC domain-containing protein. (541 aa)
TELO2Telomere maintenance 2. (860 aa)
LIG1DNA ligase. (922 aa)
ENSSTOP00000026272CS domain-containing protein. (150 aa)
LOC101973038UmuC domain-containing protein. (265 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3127 aa)
PTGES3CS domain-containing protein. (182 aa)
LOC101962631Prohibitin. (247 aa)
Pola1DNA polymerase. (767 aa)
LOC101963381Prohibitin. (297 aa)
LIG4DNA ligase. (911 aa)
LOC101975245HATPase_c domain-containing protein. (733 aa)
I3NE23_ICTTRANK_REP_REGION domain-containing protein. (150 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PhbProhibitin. (272 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
TK1Thymidine kinase. (234 aa)
SPHK1Sphingosine kinase 1. (385 aa)
Zbtb1Uncharacterized protein. (713 aa)
SPATA22Spermatogenesis associated 22. (345 aa)
TREX1Three prime repair exonuclease 1. (304 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1079 aa)
I3N2L3_ICTTRUncharacterized protein. (64 aa)
Cdkn2dANK_REP_REGION domain-containing protein. (166 aa)
Pold3Uncharacterized protein. (467 aa)
POLNDNA polymerase nu. (843 aa)
Dkc1PUA domain-containing protein. (487 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
I3M249_ICTTRUncharacterized protein. (683 aa)
PAM16Presequence translocase associated motor 16. (125 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
POLIDNA polymerase iota. (720 aa)
PRIMPOLPrimase and DNA directed polymerase. (555 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (215 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (306 aa)
LIG3DNA ligase. (1013 aa)
POLGDNA polymerase gamma, catalytic subunit. (1221 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (504 aa)
SPRTNSprT-like N-terminal domain. (489 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
PclafPAF domain-containing protein. (111 aa)
I3MXT5_ICTTRPUA domain-containing protein. (485 aa)
Nop10Uncharacterized protein. (64 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (592 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2282 aa)
CCN2Cellular communication network factor 2. (348 aa)
I3MU87_ICTTRProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (250 aa)
SIRT1Sirtuin 1. (602 aa)
WRNIP1WRN helicase interacting protein 1. (662 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (473 aa)
LOXLysyl oxidase. (397 aa)
Pold4Uncharacterized protein. (107 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1246 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
WRNWRN RecQ like helicase. (1448 aa)
HROBChromosome 17 open reading frame 53. (614 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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